Cisco HyperFlex HX-Series [EOL] vs Nutanix Cloud Infrastructure (NCI) comparison

Cisco and Nutanix are both solutions in the HCI category. Additionally, 89% of Cisco users are willing to recommend the solution, compared to 94% of Nutanix users who would recommend it.

Cisco HyperFlex HX-Series [...

Read 90 Cisco HyperFlex HX-Series [EOL] reviews

89% willing to recommend

Nutanix Cloud Infrastructur...

Read 198 Nutanix Cloud Infrastructure (NCI) reviews

16,214 Views
8,431 Comparison Views

94% willing to recommend

Cisco HyperFlex HX-Series [...

Nutanix Cloud Infrastructur...

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Executive SummaryUpdated on Jul 27, 2025

Nutanix Cloud Infrastructure and Cisco HyperFlex HX-Series compete in the hyper-converged infrastructure space. Nutanix appears to have the upper hand with its extensive feature set and cost-effectiveness, while Cisco offers strong integration within its ecosystem.

Features: Nutanix Cloud Infrastructure features data protection, one-click upgrades, and a comprehensive management interface that simplifies scalability. Cisco HyperFlex HX-Series excels in integration, flexibility, and scalability, forming a strong component within the Cisco ecosystem.

Room for Improvement: Nutanix could improve its pricing models and compatibility with older systems, and refine network features. Cisco HyperFlex HX should enhance its documentation, integration capabilities, and reduce reliance on specific hardware configurations.

Ease of Deployment and Customer Service: Nutanix is praised for easy deployment in both on-premises and hybrid environments, with top-tier technical support. Cisco HyperFlex provides reliable support, though the setup process is complex for cloud integrations, and has a steep learning curve for new users despite strong integration with Cisco products.

Pricing and ROI: Nutanix is cost-effective, typically seen as cheaper than Cisco and offers high ROI through reduced operational costs. Cisco HyperFlex is more expensive, potentially lacking a pricing advantage unless bundled with other Cisco products, which can affect ROI negatively, especially in smaller setups.

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August 2025

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Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Categories and Ranking

Cisco HyperFlex HX-Series [...

Average Rating

8.0

Reviews Sentiment

6.7

Number of Reviews

Ranking in other categories

No ranking in other categories

Nutanix Cloud Infrastructur...

Average Rating

8.6

Reviews Sentiment

7.4

Number of Reviews

198

Ranking in other categories

Software Defined Storage (SDS) (5th), HCI (4th), Software Defined Data Center (SDDC) (1st), Hybrid Cloud Computing Platforms (4th)

Featured Reviews

Nuno Mendes

IT Manager - Resp.Department at Parvalorem

High performance solution that makes it easy to efficiently manage VM resources

In our case as a credit recovery company working with the state, our infrastructure is fixed and stable as we don't have the same need for growth as other types of companies. That said, one of the biggest problems with HyperFlex HX is that if you want to adjust your solution in terms of processing power, memory, or disk capacity, you have to buy completely new hosts. From a financial perspective, it can be very expensive to do so, and from a legal perspective, there are all kinds of compliance issues we would have to sort out before buying any new solution or application. Since we as a company will only be operating for perhaps the next ten years, when our HyperFlex solution comes to its end-of-life in 2024 our next step will likely not be with HyperFlex or any other solution from Cisco. Instead, from a financial point of view, we will likely turn toward a cloud solution because, that way, we won't have to spend so much money on physical infrastructure. We are, after all, only a small company and HyperFlex can be very expensive for other companies of our size, whether in Portugal or elsewhere like the United States. One other area for improvement is in regard to HyperFlex's integration with VMware. HyperFlex integrates with a specific version of VMware in such a way that HyperFlex doesn't always resolve security issues with VMware at the same pace as what you see in native implementations of VMware. This has happened in one or two situations in the past. On the other hand, the integration is otherwise adequate, especially in terms of availability and virtualization features (such as being able to split up each of our four hosts within VMware).

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MahendraPanchotiya

Infrastructure Manager at ER Tech Pros

Offers a unified platform, reduces downtime, and simple updates

Nutanix offers a unified platform for managing databases, virtual machines, and applications. This simplifies management by consolidating everything into a single interface. While Nutanix may have a higher upfront cost compared to other hypervisors, it can significantly reduce the resources needed for infrastructure management. With our previous hypervisor, we needed nearly ten IT personnel. Nutanix has allowed us to streamline our team to just three members. We use a combination of database technologies, including SQL databases and web servers such as IIS, BHP, and NGINX. Nutanix features helped our organization reduce downtime. I don't recall the last time we had downtime related to Nutanix because it is such a stable product. Nutanix, a reliable product, helps us streamline our processes, which in turn improves company revenue. We began to see the benefits after two years, with a 40 percent reduction in operational costs. We migrated 200 servers from AWS to Nutanix. Nutanix may not consolidate applications, but it helps us run them more efficiently on its platform. Updating is simple with one click. I would rate the updating processes 10 out of 10. Adding compute and storage on demand is not difficult. However, we need to factor in the existing and new firmware and software requirements.

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Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Pros

"Cisco provides the ability to configure BIOS, something that no one else can do, on a remote basis. That's really helpful sometimes. The bus-snooping alteration tool for BIOS is fantastic. That's one of the game-changing features that Cisco alone has at this point."

"This is not the only product we use, so we have other solutions to compare it with. We can compare different products and different vendors and tell our customers which products have which advantages and disadvantages so that they can leverage these products in their own environment. This product helps us to understand the customer's needs and what issues they can run into."

"The ROI we have seen from the high performance that has saved us time and money."

"I love the Cisco design, the visual interface to manage and use the platform."

"Its most valuable feature is its flexibility."

"The initial setup was straightforward. With our partners and the consultancy that we had, we knew what we wanted to do. Therefore, we didn't have any problems with the installation and parametrization."

"Great integration with backup software."

"The possibility to share the workload is one of its most valuable features. We have many applications which have need of workloads only a few times in a month, so we share HyperFlex with them."

More Cisco HyperFlex HX-Series [EOL] pros

"There are a lot of features in Nutanix that are different from other hyper-converged solutions, such as site-to-site replication. VM-based site-to-site replication is bundled with the software licensing. For the DR, it has the availability groups, which is one of the key features that Nutanix provides."

"In addition to the hyper-converged infrastructure, most of our clients are pleased with Acropolis' built-in replication in terms of the DR setup. Our clients also like Prism Central's advanced management and analytics, and many find Nutanix Flow and playbooks incredibly useful."

"Nutanix Cloud Infrastructure has a simple, user-friendly GUI, and I also like the remote recovery capabilities. It provides a single platform for managing databases."

"Management is simple"

"The most valuable features are simple management and one-click upgrades."

"We have had good feedback from our customers about this solution."

"Acropolis has a great interface and lots of management features packaged with it at an affordable price."

"Nutanix does a superb job with technical support."

More Nutanix Cloud Infrastructure (NCI) pros

Cons

"The initial setup can be complex."

"We had a bit of complexity to think about how to migrate our legacy infrastructure into Cisco HyperFlex."

"You cannot just apply the VSXi updates. You are dependent on Cisco HyperFlex for metric services, analytics, and everything else. I don't like that dependency."

"The solution's price could be affordable."

"The scalability could use improvement."

"Sometimes when there are multiple technologies involved in a support case, this is when there is a bit of a lag."

"The infrastructure team thinks that there are a lot of issues."

"We would like HyperFlex to connect the storage directly into Fabric Interconnect along with the features of the solution. We have enough ports in HyperFlex. We don't want to buy another set of switches to connect to Fabric Interconnect, complicating the solution."

More Cisco HyperFlex HX-Series [EOL] cons

"It would be ideal if it was more secure."

"It would be fantastic if there was a built-in layer, in Nutanix, that acted like a cloud interface. So far, we need to integrate a cloud interface on top of Nutanix for billing the usage for specific customers' domains. It would be great if a cloud gateway was built-in, inside Nutanix."

"As Nutanix Acropolis AOS is on the expensive side, one of its areas for improvement is the price. It would also be better if it can be integrated with other cloud providers, because currently, it's only for private cloud deployment."

"The cost of the solution is too expensive. There are other options, such as VMware, that are offered for less money. In Latin America, it seems to be overpriced for the market."

"The name of the solutions offered by Nutanix does not indicate what the tool does."

"One thing I've noticed is that, when you do a shift from VMware to Nutanix, it opens the setup of the VM that's currently running. If people from another site double click on it, it opens the VM instead of the setup of the unit. So I would suggest that this could perhaps be switched. That is so far the only change I would like. I would like it if they could fix the instance where you double click on a VM and it opens the VM instead of the setup. That's the only thing that's a major bother to me."

"This solution offers excellent functionality but could use a stronger interface."

"Nutanix should improve AHV to support migration VMs between clusters and storage containers. Migration between containers is possible, but it requires shutting down the VM. The procedure is long and there is no migration between clusters at all."

More Nutanix Cloud Infrastructure (NCI) cons

Pricing and Cost Advice

"Cisco HyperFlex HX-Series is expensive. It's a standard license, and we pay for it yearly. I think we pay about 700."

"Comparable solutions with switches, storage, and services are cheaper than HyperFlex. It should be cheaper."

"The price is a bit high. It could be better, but the product is worth the cost."

"I would like the pricing to be cheaper."

"There is a license required to use this solution."

"One of the challenges we have with HyperFlex is that they have a subscription fee for the operating system that runs on it, and if I remember correctly, it costs approximately $15,000 USD per month."

"When we negotiated with Cisco for the HyperFlex solution, they gave us a good price because they wanted to break into the market in Portugal for the first time. However, in general, I think it's a very expensive solution. It's a huge amount of money to acquire this kind of infrastructure."

"There is a 30 percent additional premium that all the companies are charging for Cisco HyperFlex HX-Series because of the lack of chips and bottlenecks in the market. The cost of the solution is high right now."

More Cisco HyperFlex HX-Series [EOL] pricing and cost advice

"I think it's cheaper than VMware in terms of cost."

"When we purchase a new physical server or a couple of physical servers into our cluster, we always purchase it with Nutanix licensing. We are receiving the license from Nutanix directly and not from the vendor. In the way we're dealing, with the licenses it is a bit costly for us but as the company is getting larger, day by day or year by year, those licensing costs become lower each time for us. We are purchasing the licenses for three years for some of our clusters and for some others for five-year licenses and the licenses are still costly. We have good discounts for the licenses, but it is still expensive."

"We renew our license on a yearly basis and have no costs in addition to the standard fee."

"Its licensing model is easy, but the bad thing is that we need to pay for the whole capacity at once. With VMware vSAN, we only have to pay for the capacity that we are using, which is not the case with Nutanix. So, we have more overhead for the licensing cost with Nutanix."

"It's a bit expensive, but it's worth it."

"It is not cheap, but if you look at the return on investment and the total cost of ownership, it is worth the price."

"The price of Nutanix is lower than other products."

"Nutanix Cloud Infrastructure’s pricing is very good and competitive."

More Nutanix Cloud Infrastructure (NCI) pricing and cost advice

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Comparison Review

it_user244362

Managing Consultant with 51-200 employees

Aug 30, 2015

Nutanix vs. VMware EVO:RAIL vs. FlexPod

Originally posted at www.storagegaga.com/dont-get-too-drunk-on-hyper-converged/ I hate the fact that I am bursting the big bubble brewing about Hyper Convergence (HC). I urge all to look past the hot air and hype frenzy that are going on, because in the end, the HC platforms have to be aligned…

Read full review

Answers from the Community

Netanya Carmi

Content Manager at PeerSpot

Aug 2, 2022

How do I choose between Cisco Hyperflex HX Series and Nutanix Acropolis AOS?

See 2 answers

Leah Fainchtein Buenavida

Tech Blogger

Oct 17, 2021

Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis. We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrated Managed Controller was a nice feature to have. It is expandable, stable, and has good redundancy. If you require more processor cores per box, Cisco HyperFlex is a good solution for you. Support will depend on the type of contract you have, with some requests taken care of immediately and others taking longer according to the engineer’s expertise. While Hyperflex is designed for any company size, I wouldn’t recommend them for small businesses. It also requires a solid knowledge of Cisco products, as the UI can be difficult to manage. Upgrading to a newer version can also be cumbersome and could use some improvement. We chose Nutanix because it is easier to use and is more cost-effective. Nutanix allows us to deploy, run and scale applications both on-premises and in the cloud. It has excellent support. You can log the query straight to a technical expert, which is good if you have staff not familiar with AOS. It is easy to scale by adding new nodes, and the company is constantly adding new features. Nutanix is not for everyone, though. The Nutanix Cloud System can be complex to maneuver when at the command line or when troubleshooting. Conclusions Nutanix is better for medium-sized companies and when you need a cost-effective solution. Cisco Hyperflex is a complete solution but is better suited for large enterprises. It works better if you are already a Cisco user.

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Steffen Hornung

Administrator at Neuberger Gebäudeautomation GmbH

Aug 2, 2022

With Nutanix you have the freedom of choice. You can deploy it with several server hardware vendors or completely in the cloud. I don’t know Hyperflex at heart, though. Also, support at Nutanix is outstanding.

Read full answer

Top Industries

By visitors reading reviews

Computer Software Company

19%

Financial Services Firm

Government

Manufacturing Company

Computer Software Company

17%

Financial Services Firm

Manufacturing Company

Government

Company Size

By reviewers

Large Enterprise

Midsize Enterprise

Small Business

Questions from the Community

How do I choose between Cisco Hyperflex HX Series and Nutanix Acropolis AOS?

Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper...

See all answers

How does VxRail compare with Cisco HyperFlex HX Series?

VxRail provides stable solutions for technical problems while at the same time not being too expensive for a company to invest in. Even if you are working with a limited budget, this platform offer...

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What do you like most about Cisco HyperFlex HX-Series?

It's easy to get the tool started.

See all answers

What is the biggest difference between Nutanix Acropolis and VMware vSphere?

We found the reduced power consumption with Nutanix Acropolis AOS a very attractive feature. We also like the interface that allows you to talk directly to your VM from the present software. We fou...

See all answers

Which would you choose - Nutanix Acropolis AOS or VMware vSAN?

See all answers

What makes Nutanix Cloud Infrastructure (NCI) worth using?

NCI is a product with many tools and services but the one that, in my opinion, makes it better than similar products and worth using, is the full-stack lifecycle management. This capacity allows u...

See all answers

Comparisons

HPE SimpliVity vs Cisco HyperFlex HX-Series [EOL]

Compared 47% of the time

VMware vSAN vs Cisco HyperFlex HX-Series [EOL]

Compared 24% of the time

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VxRail vs Nutanix Cloud Infrastructure (NCI)

Compared 7% of the time

Sangfor HCI - Hyper Converged Infrastructure vs Nutanix Cloud Infrastructure (NCI)

Compared 7% of the time

Azure Stack HCI vs Nutanix Cloud Infrastructure (NCI)

Compared 6% of the time

HPE SimpliVity vs Nutanix Cloud Infrastructure (NCI)

Compared 6% of the time

VMware vSAN vs Nutanix Cloud Infrastructure (NCI)

Compared 6% of the time

More Nutanix Cloud Infrastructure (NCI) Competitors

Product Reports

Buyer's Guide

Cisco HyperFlex HX-Series [EOL]

August 2025

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Buyer's Guide

Nutanix Cloud Infrastructure (NCI)

August 2025

Nutanix Cloud Infrastructure (NCI) report

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Also Known As

No data available

Nutanix Acropolis AOS, Nutanix AOS, Nutanix Acropolis

Overview

The Cisco HyperFlex HX Data Platform is a purpose-built, high-performance, scale-out file system with a wide array of enterprise-class data management services. The data platform’s innovations redefine distributed storage technology, giving you complete hyper-convergence with enterprise storage features:

Enterprise-class data management
Continuous data optimization
Securely encrypted storage
Dynamic data placement
Clusterwide parallel data distribution
Linear and incremental scaling
API-based data platform architecture
A simplified approach

Cisco

Nutanix Cloud Infrastructure (NCI) is a top-ranking HCI software, cloud management tool, and Software Defined Storage (SDS) tool that is marketed as the foundation for users' hybrid clouds. It offers a powerful and secure hyperconverged infrastructure to deliver all data and applications at any scale and on any cloud. The solution offers a complete software stack that allows users to unify their hybrid cloud infrastructure.

NCI’s services include computer, storage and network, hypervisors and containers, and deployment in public or in private clouds. The product also comes with built-in resilience, disaster recovery capabilities, self-healing, and high-security capacities. It provides further deployment flexibility through several software and hardware options and platforms. NCI includes a full set of enterprise capabilities. It can also be deployed on a wide range of servers from popular manufacturers.

The capabilities of the product are categorized into three main groups:

AOS storage
Flexible and open compute
Automated and secure networking

Outside of these categories, NCI also offers other capabilities:

Integrated disaster recovery
Full-stack lifecycle management
VMware with Nutanix
Intelligent operations

Nutanix Cloud Infrastructure (NCI) Features

Nutanix Cloud Infrastructure (NCI) offers its customers various features and tools in each of the previously mentioned categories. The available features for users currently include:

High-performance: This set of features utilizes hardware advances such as NVMe and RDMA to accelerate users' most demanding applications with consistent performance. The tools in this feature category work alongside data locality to ensure successful results.
Foolproof resiliency: These Nutanix Cloud Infrastructure features protect data and keep it available by facilitating advanced distributed consistency algorithms. Users can utilize these features to protect their data from issues like bit rot, hardware failures, and even entire site failure.
Flexibility: This set of features allows storage to be sized for the needs of each organization and expanded promptly and easily so that the organization and its data can grow. The features offer flexibility to users in terms of applying storage policies logically on a pre-workload basis, instead of being tied to hardware.
Hypervisor choice: Users can choose from the leading hypervisors - Microsoft Hyper-V or VMware ESXi. They can also leverage the built-in hypervisor AHV that Nutanix Cloud Infrastructure (NCI) provides.
Integrated virtualization: These features offer simplified automation and AHV streamlined operations. The services in this category are optimized for high performance and reliability.
Kubernetes: Nutanix Cloud Infrastructure (NCI) offers features to build and deploy cloud-native applications on intelligent distributed infrastructure. Apps can be integrated with cloud-compatible storage and both building and deployment can be achieved within the same platform.
Microsegmentation: Nutanix Cloud Infrastructure (NCI) offers features to prevent malware spread and reduce attack surfaces by leveraging machine learning (ML).
Virtual networking: This set of features allows users to easily implement multi-tenancy in their environment or stretch networks across clouds.
Centralized network management: Nutanix Cloud Infrastructure (NCI) provides organizations with a way to manage networking configurations centrally. Users can utilize it across their human-computer interaction (HCI) environment with simple virtual switch management.

Nutanix Cloud Infrastructure (NCI) Benefits

The product offers various benefits to users who utilize its capacities. Some of these include:

NCI reduces technology sprawl and frees up technical resources to allow organizations to focus on other activities, potentially reducing costs for the business.
The product allows customers to deploy, scale, and bridge to the public cloud to be able to react in evolving business environments.
Nutanix Cloud Infrastructure improves data availability while simultaneously protecting it against several kinds of failures and attacks.
The solution offers high-performance, resilient distributed storage for all workloads.
Working alongside Nutanix Cloud Platform, NCI offers simple management of data from one console.
Nutanix Cloud Infrastructure works by the zero trust philosophy, protecting users' apps and data through specially designed security protocols.

Reviews from Real Users

According to Gerhard J., an IT manager at Q4 Fuel, Nutanix Cloud Infrastructure (NCI) provides serious reliability and stability across the entire system makes for ROI.

A solutions architect at a computer software company describes NCI as a stable, straightforward to set up, and scalable solution.

Nutanix

Sample Customers

BluePearl Veterinary Partners, Ready Pac Foods, Bryant University, Bellevue Group, KPIT Technologies, City Harvest

St. Lukes Health System, the City of Seattle, Yahoo! Japan, Sligro, Empire Life, Hyundai AUS, and many others.

Find out what your peers are saying about Dell Technologies, VMware, Nutanix and others in HCI. Updated: August 2025.

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