Cisco SecureX [EOL] vs Microsoft Defender XDR comparison

Why PeerSpot?

Cisco and Microsoft are both solutions in the Extended Detection and Response (XDR) category. Additionally, 100% of Cisco users are willing to recommend the solution, compared to 98% of Microsoft users who would recommend it.

Comparison Buyer's Guide

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Executive SummaryUpdated on Nov 2, 2025

Cisco SecureX and Microsoft Defender XDR compete in the realm of integrated security platforms. Based on the data, Cisco SecureX has the upper hand in integration across both Cisco and third-party solutions, providing comprehensive management of incidents. Microsoft Defender XDR, however, excels in seamless integration within the Microsoft ecosystem, offering robust threat detection and response.

Features: Cisco SecureX offers integration and visibility across diverse security environments, threat hunting, and a comprehensive incident management dashboard. Microsoft Defender XDR provides a unified view of threats, strong endpoint security, and seamless integration with Microsoft tools like Sentinel.

Room for Improvement: Cisco SecureX needs simplified automation and better third-party integration. Enhancing its documentation would also improve user effectiveness. Microsoft Defender XDR could benefit from clearer licensing, more intuitive dashboards, and improved third-party integration. Enhancing automated response and reducing false positives are key focus areas.

Ease of Deployment and Customer Service: Cisco SecureX is deployable across diverse environments and is praised for swift customer support and integration assistance. Microsoft Defender XDR supports diverse cloud and hybrid deployments, though users note variability in support response times during complex integrations.

Pricing and ROI: Cisco SecureX offers cost-effective integration with existing Cisco products, providing substantial ROI by automating security processes. Microsoft Defender XDR is pricier yet offers comprehensive features within the Microsoft ecosystem. ROI comes from improved threat response and integration efficiency, though pricing clarity and flexibility could be improved.

To learn more, read our detailed Extended Detection and Response (XDR) Report (Updated: October 2026).

Buyer's Guide

Extended Detection and Response (XDR)

October 2026

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Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Categories and Ranking

Cortex XDR by Palo Alto Net...

Featured Reviews

ABHISHEK_SINGH

Senior Process Expert at A.P. Moller - Maersk

Gained full visibility and streamlined threat detection through behavior-based insights and AI integration

Initially, we got to have a lot of false positives when we onboarded, but nowadays it's quite smooth. We have fine-tuned our security policies and allowed different levels of policies to get rid of those false positives. Currently, we are getting a fairly good amount of incidents that are not false positives or benign, but actionable items. The process is streamlined. In the initial days, the operations used to get involved in a lot of benign and other activities, but now the process is streamlined. We are leveraging the auto-detection and remediation plans. The operations teams are now more involved in other business roles as well, not just looking into the logs and fetching out what's happening there. They have fixed a lot of things. Initially, they didn't have IAC code drift detection, cloud posture management, or security posture management, but they have those now. They purchased different vendors and did a merger with that. They have now Prisma Cloud that gets integrated and now they are working with Cortex Cloud. Everything that was negative has now been addressed, and the product altogether looks to be in a very better and mature shape now. Currently, it's more or less detecting the workloads with AI-based best practices. Since most organizations are consuming AI agents and other things, we are looking forward to seeing what other feature enhancements Palo Alto can support in that.

Read full review

Dene Lewis

Head of Technical Strategy and Direction CAE Technology Services Ltd at CAE Technology Services Limited

A scalable SaaS based platform that helps with cyber threat intelligence and automated hunting

I would rate Cisco SecureX a ten out of ten. I find the product to be a fantastic platform. If you are eligible, start using it straight away. The best way to evaluate it is to start using it and see where it fits within your organization. I think it helps our customers really deliver their SecOps goals, and I see it as a core foundation of CAE's own security strategy going forward. Our partnership with Cisco is one that was built on trust over a long period of time. This has enabled us to work together to be able to provide the solutions that our customers need to drive their organizations forward. The value we add as a reseller is being able to work closer with our customers, understand them, and get intimate with their organizations. That enables us to offer them the right solutions that will help them achieve their goals.

Read full review

reviewer2812758

Infosec at a government with 10,001+ employees

Integrated defenses have unified threat hunting, phishing simulations, and identity investigations

I appreciate Microsoft Defender XDR's MDE, Microsoft Defender tool, which has Attack Simulator. Instead of doing a phishing campaign and getting a separate tool, Microsoft Defender XDR does it all. These features of Microsoft Defender XDR have helped us conduct a phishing campaign quarterly, which has been beneficial. I also appreciate the fact that it has Defender for Office integrated, Defender for Identity, and everything integrated together. I would describe the process of using Microsoft Defender XDR to prioritize incidents in my security operations as quite decent. I appreciate the automatic alerting system where any incidents or alerts we receive come directly to our email. From there, we can open the email, go directly to Microsoft Defender XDR, and start our investigations and remediations. I perceive the integration of security and identity access management in Microsoft Defender XDR as affecting my identity protection strategies very well because it is well integrated with Purview, integrated well with Entra ID, and integrated well with Exchange. I especially appreciate MDO, the Office product. If anything happens and I want to conduct an investigation, it takes me directly to Exchange, where I can also investigate any emails or phishing incidents. Instead of going to different portals, everything can be done from Microsoft Defender XDR. If necessary for further investigation, Microsoft Defender XDR then directs me to that environment. I would assess the integration of AI in guiding security actions within Microsoft Defender XDR as quite positive. Recently, Security Copilot went big, and it is beneficial that I can use that, especially to write KQL. I can do threat hunting features and intelligence all within using Microsoft's Security Copilot. It also has a nice AI feature for threat hunting. I know that all the Defender logs go to Sentinel, and I can pull it up from Microsoft Defender XDR or from Sentinel. The fact that I can actually do all that within Microsoft Defender XDR is a nice feature. In the top module, I can do threat lookups, and I can actually type KQLs in Microsoft Defender XDR and look up incidents. Predictive shielding has had a nice impact on my proactive security measures. It is beneficial that it has, similar to Entra ID, a secure score. For me to improve the product, the secure score helps me out. If I rate it from highest to lowest, I can see what things I can improve. Secure score helps me see what areas I can improve in Microsoft Defender XDR to increase my score and bring it to 80 or more. Knowing Microsoft Defender XDR from using it since 2019, before COVID days, I know that they have improved significantly. It is much more user-friendly and has a very nice vulnerability feature that I find handy and useful. The fact that this feature integrates into Intune is also very decent.

Read full review

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Pros

"The integrations are out-of-the-box, as are the playbooks."

"The live terminal is probably the best thing ever. It gives you the access to get straight onto any machine."

"Once you become familiar with it, Cortex XDR by Palo Alto Networks is a more powerful tool and I would say that I prefer it over MDE because it is a stronger tool for me."

"The solution allows us to gain remote access without the user's knowledge and take the necessary actions on the device."

"The product's most valuable features are massive user and feature intelligence exploit detection."

"The most valuable features are incident creation, policy-based protection, IP whitelisting, and device encryption. These are beneficial for endpoint and server security."

"Cortex XDR is a simple platform that's easy for administrators and users. You have a lot of flexibility to change or customize the features."

"I have found the solution to be very easy in respect of the integration and configurable."

More Cortex XDR by Palo Alto Networks pros

"One of the most valuable features is the simplicity of deploying SecureX. It's very easy to do that and then you gain very detailed visibility into everything that's going on in your network and, obviously, at the device level. There's just a wealth of information that you can pull from all of these products that are part of SecureX. You know exactly if you have an issue or not."

"Its cybersecurity and resilience have been extremely important for our organization."

"Using SecureX, we can aggregate the data from all our security products, automate many of our tasks that we had to do manually before, save a huge amount of time, and provide many reports about usage of our systems and networks to our leaders and managers to show what we can do to make our security better."

"SecureX definitely provides us with contextual awareness throughout our security ecosystem, since it allows us to integrate multiple threat intelligence feeds, as well as multiple security appliances and platforms."

"It has evolved a lot, just that monitoring piece to the current Orchestrator piece. The additional analytics are there. They now have something called Insight, which can basically take data from Microsoft Azure AD and Intune to give us information about our endpoints. This is detailed information about the endpoints, from Secure Endpoint and all these different products. So, it is just constantly evolving. Every time that it evolves, we have more information with more visibility. There are more features that we have that just make everything so much easier, and it is in one place. I don't have to keep going back and forth. I don't have to go to Secure Endpoint and ISE to get the data. I don't have to go to Intune on Microsoft to get the information. It is all in one place."

"The most beneficial feature of Cisco SecureX for cybersecurity efforts is its integration with other Cisco solutions and the environment. This sets it apart, as its APIs and overall integration capabilities are very strong. Additionally, its detection capabilities are commendable."

"We've reduced our workload by 20 to 30 percent just from being able to focus on the important things, as this product really does a lot of the grunt work for you."

"If management wants to ingest reports at a high level from all of the different products, they would only need one login to SecureX to view this information as opposed to separate logins for each of the integrated products."

More Cisco SecureX [EOL] pros

"The stability has been great."

"The ability to integrate and observe a more cohesive narrative across the products is crucial."

"We are connected to Microsoft and have every laptop enrolled. This acts as an endpoint. The tool helps me check security and compliance. I can also check what a device is doing."

"The most valuable feature depends on the scenario. For compliance, I like Microsoft Purview Information Protection and Data Loss Prevention. Sentinel is the most helpful feature for security. 365 Defender helps us prioritize threats across an enterprise. It's a crucial feature for the managed services team."

"The most valuable features are machine learning, AI, and auto-remediation of none malicious alerts."

"The most valuable features are spam filtering, attachment filtering, and antivirus protection."

"I like how Microsoft XDR and the other Microsoft products are integrated into a single unified security stack covering identity access management, endpoint protection, email, cloud applications, etc."

"The most valuable feature is the DLP because that's where we can have an added data protection layer and extend it not just to emails but to the documents that users are working on. We can make sure that sensitive data is tagged and flagged if unauthorized parties are using it."

More Microsoft Defender XDR pros

Cons

"In terms of areas of improvement, we have not completed our review of the product. We're also looking at other products. So, it's a little bit hard to tell what could be different because we have not completed the review of this product, but based on our experience so far, its implementation is quite complex."

"Previously, the endpoint would leave the environment, not being on our VPN, essentially unable to interact with the server to upload files. It was unable to retrieve new file verdicts. It was using a thing called "local analysis" to determine if something was a malicious file or not. There was no dynamic analysis."

"The connection to the internet has not performed as expected."

"It's very time-consuming to log support issues and the people that answer the tickets aren't very knowledgeable."

"The solution should add unwanted malicious hash values to a block list so that whenever the action is triggered, it will automatically prevent the malicious content."

"However, if you do not have Palo Alto in your environment, you are paying these additional services just for Cortex XDR by Palo Alto Networks, so it is not a cost-effective solution."

"For Cortex XDR by Palo Alto Networks, if I had to point out improvements, I would say the UI is still somewhat difficult for beginners."

"The product's pricing needs improvement. They could provide more discounts. Additionally, the dashboard and control panel could be enhanced."

More Cortex XDR by Palo Alto Networks cons

"The documentation can be improved and the on-prem integration. The set of applications that it was integrated with wasn't comprehensive."

"Remediation stuff could be integrated into the product's automation."

"It would be nice if they had a different pricing model. Most of our budget for projects goes towards Cisco."

"One of the improvements the product needs is more integration with collaboration platforms."

"For us, the biggest sticking point is that the product is not being designed for multi-tenancy use at present, from an MSP perspective."

"I would rate this solution 7 out of 10. It's a great idea if it worked consistently, but it has to be way more mature than when I used it."

"They could expand into more areas."

"The automation and orchestration could be simpler. It could be that all the other parts are that easy to use so that these stick out as a negative, but that's the trickiest part for us. The workflows within the orchestration are just a bit more difficult."

More Cisco SecureX [EOL] cons

"The only problem I find is that the use cases are built-in. There is no template available that you can modify according to your organization's standards. What they give is very generic, the market standard, but that might not be applicable to every organization."

"Microsoft frequently changes the names of its products, sometimes even renaming entire portals or features."

"Customers say they want absolutely seamless integration between other Microsoft solutions and Defender XDR, including the ability to change device settings within the Defender portal. They need to contact the IT team responsible for the device management tools to change some settings. They would prefer that those changes be initiated directly from the Defender portal or applied from Intune without involving the IT operations team."

"From my perspective, Microsoft Defender XDR can be improved with better visibility in certain areas where I can trigger host isolation on one machine."

"Microsoft Defender is slow to adapt to evolving threats."

"Microsoft tends to provide too many features, which makes the solution prone to bugs."

"What could be improved in Microsoft 365 Defender is its licensing, e.g. it should be more consolidated and would be good if it has some optimizations. Improving the alerts and notifications, in terms of adding more details, would also be good for this solution."

"There are a few technical issues with Defender XDR that can be improved. Sometimes, the endpoint devices are not reporting properly to the Defender 365 portal. When you're getting all the information from the Microsoft portal, the devices are sometimes not in sync. We have hundreds of endpoint devices, some needing to be onboarded again."

More Microsoft Defender XDR cons

Pricing and Cost Advice

"It's about $55 per license on a yearly basis."

"Traps pays for itself within the first 16 months of a three-year subscription. This is attributed to OPEX savings, as security teams spent less time trying to identify and isolate malware for analysis as a result of a reduction in malware incidents, false positives, and breach avoidance."

"Every customer has to pay for a license because it doesn't work with what you get from a managed services provider."

"The cost depends on your chosen license type, like Pro or other licenses."

"The cost of Cortex XDR by Palo Alto Networks is $55 to $90 USD per endpoint per month."

"I don't recall what the cost was, but it wasn't really that expensive."

"The price of the solution could be reduced. I have customers that have voiced that the solution is good for the value but if I want to sell more of the solution the price reduction would help."

"Our customers have expressed that the price is high."

More Cortex XDR by Palo Alto Networks pricing and cost advice

"It would be nice if they had a different pricing model. Most of our budget for projects goes towards Cisco."

"The product is absolutely free to any customer. As such, the only thing one must keep in mind is that as long as he already has one Cisco security product, irregardless of what that product is, SecureX is available for free."

"The pricing is the best part of this solution. It is free if you buy Umbrella or Duo Security. It is also a good solution."

"You can spend less money for another solution, but if you really want to have a good solution you have to pay. We are happy that we are getting such a good solution for what we are spending."

"It is free. It can't get any better than that."

"It comes free with all Cisco products. So, it is a good price."

"The pricing is competitive, especially for education institutions. Licensing can be a little bit difficult to navigate, especially with resellers with Cisco, but for us it has been pretty easy."

"Cisco SecureX is more expensive than Trend Micro. However, considering the integration capabilities with other solutions and the quality of technical support, I believe there's justification for the price difference."

More Cisco SecureX [EOL] pricing and cost advice

"The licensing fee for Microsoft 365 Defender is fair."

"The product is fairly priced for what we get from it."

"The license cost for a year is approximately forty-four thousand, and this annual saving is a significant factor in our decision to switch."

"The functionality is fantastic, but for medium and small-sized companies it's overpriced. It would be better if it were a little bit cheaper."

"Microsoft purposely makes its license combinations complex and includes combinations like Microsoft 365 E3 and Microsoft 365 E5, Office 365 E3, Office 365 E5, and Office 365 E1, so you get confused. Microsoft tries to sell you a bundle of a lot of things together."

"We have a lot of problems in Latin America regarding the price of Microsoft 365 Defender, because the relationship between dollars and the money of the different countries, it's is a lot. Many customers that have small businesses say that they would like the solution but it is too expensive. However, large companies do not find the cost an issue."

"365 Defender is billed per account. I don't know the exact price, but my supervisor told me that Microsoft Defender is cheaper than the alternatives. It's bundled, so you get all the features in one place."

"Microsoft Defender XDR is already included in our Office 365 licensing. It is better because we're saving money by using it."

More Microsoft Defender XDR pricing and cost advice

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Top Industries

By visitors reading reviews

Comms Service Provider

14%

Outsourcing Company

12%

Construction Company

10%

Manufacturing Company

10%

Outsourcing Company

22%

Construction Company

12%

Marketing Services Firm

University

Financial Services Firm

Outsourcing Company

Comms Service Provider

Computer Software Company

Company Size

By reviewers

Large Enterprise

Midsize Enterprise

Small Business

By reviewers
Company Size	Count
Small Business	50
Midsize Enterprise	21
Large Enterprise	57

By reviewers
Company Size	Count
Small Business	4
Midsize Enterprise	7
Large Enterprise	3

By reviewers
Company Size	Count
Small Business	46
Midsize Enterprise	28
Large Enterprise	41

Questions from the Community

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How is Cortex XDR compared with Microsoft Defender?

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What is your experience regarding pricing and costs for Microsoft 365 Defender?

My experience with the pricing, setup costs, and licensing of Microsoft Defender XDR is that we are on an E5 license,...

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What needs improvement with Microsoft 365 Defender?

From my perspective, Microsoft Defender XDR can be improved with better visibility in certain areas where I can trigg...

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What is your primary use case for Microsoft 365 Defender?

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Comparisons

Microsoft Defender for Endpoint vs Cortex XDR by Palo Alto Networks

Compared 16% of the time

SentinelOne Singularity Endpoint vs Cortex XDR by Palo Alto Networks

Compared 4% of the time

CrowdStrike Falcon vs Cortex XDR by Palo Alto Networks

Compared 4% of the time

Symantec Endpoint Security vs Cortex XDR by Palo Alto Networks

Compared 3% of the time

Cortex XSIAM vs Cortex XDR by Palo Alto Networks

Compared 3% of the time

More Cortex XDR by Palo Alto Networks Competitors

Quotium Seeker vs Cisco SecureX [EOL]

Compared 4% of the time

ERPScan SMART Cybersecurity Platform vs Cisco SecureX [EOL]

Compared 4% of the time

TrendAI Vision One vs Cisco SecureX [EOL]

Compared 4% of the time

TrendAI Vision One – Cloud Security vs Cisco SecureX [EOL]

Compared 4% of the time

Cisco Secure Network Analytics vs Cisco SecureX [EOL]

Compared 4% of the time

More Cisco SecureX [EOL] Competitors

CrowdStrike Falcon vs Microsoft Defender XDR

Compared 7% of the time

Wazuh vs Microsoft Defender XDR

Compared 5% of the time

SentinelOne Singularity Endpoint vs Microsoft Defender XDR

Compared 4% of the time

Microsoft Defender for Cloud vs Microsoft Defender XDR

Compared 3% of the time

Secureworks Taegis XDR vs Microsoft Defender XDR

Compared 2% of the time

More Microsoft Defender XDR Competitors

Product Reports

Buyer's Guide

Cortex XDR by Palo Alto Networks

October 2026

Download Cortex XDR by Palo Alto Networks product report

Buyer's Guide

Cisco SecureX [EOL]

October 2026

Download Cisco SecureX [EOL] product report

Buyer's Guide

Microsoft Defender XDR

October 2026

Download Microsoft Defender XDR product report

Also Known As

Cyvera, Cortex XDR, Palo Alto Networks Traps

Kenna.AppSec, Kenna.VI

Microsoft 365 Defender, Microsoft Threat Protection, MS 365 Defender

Overview

Cortex XDR by Palo Alto Networks provides advanced threat detection with AI-driven endpoint protection and seamless integration, ensuring multi-layered security and automatic threat response.

Cortex XDR is designed to safeguard endpoints against malware and suspicious activities. It offers advanced threat detection and response capabilities using behavioral analysis, AI, and machine learning. It seamlessly integrates with security infrastructures, providing endpoint security, firewall integration, and enhanced visibility in both cloud-based and on-premises environments.

What are the key features of Cortex XDR?

Advanced Threat Detection: Uses AI and machine learning for proactive threat identification.
Multi-layered Security: Combines various security measures for comprehensive protection.
Endpoint Protection: Safeguards against malware and exploits.
Behavioral Analysis: Monitors suspicious activity for early detection.
Automatic Threat Response: Automates responses to neutralize threats.

What benefits should users expect?

Ease of Use: Simplifies security management with intuitive design.
Resource Efficiency: Minimizes impact on system resources.
Integration Capabilities: Works well with existing security setups.
Reduced Analyst Workload: Automates processes to decrease manual intervention.

Organizations in diverse sectors deploy Cortex XDR to protect against malware, leveraging its advanced threat detection capabilities. Its integration with existing security infrastructures appeals to those seeking comprehensive protection in both cloud and on-premises environments, providing enhanced visibility and threat intelligence.

Palo Alto Networks

Cisco SecureX is an integrated security platform that connects the breadth of Cisco's integrated security portfolio and the customer's infrastructure to create a consistent experience. The solution unifies visibility, enables automation, and strengthens your security across network, endpoints, cloud, and applications. Cisco SecureX is embedded within every Cisco Security product and supports integrations with SIEM and SOAR, so customers will not need to replace any solution or worry about layering on new technology.

Cisco SecureX Features

Cisco SecureX has many valuable key features. Some of the most useful ones include:

Unified overview: Cisco SecureX offers key metrics on transactions and threats for network, endpoints, cloud and applications. In addition, the SecureX interface is integrated into all Cisco Security technologies.

Automation and an increase in operational efficiency: With Cisco SecureX, you gain better automation of workflows for products of the Cisco Security portfolio and third parties, allowing you to focus on other more important tasks. By eliminating manual work (through automatic identification of threats using analytical data of Cisco Talos and other sources), the solution helps your organization save a significant amount of time.

Security strengthening: Cisco SecureX makes it easy to compare analytical data from a set of various sources with the telemetry received from network, endpoints, e-mail, cloud, and third-party products.

Cisco SecureX Benefits

Some of the benefits of using Cisco SecureX include:

Secure every business endeavor with an open, integrated platform that has out-of-the-box interoperability and scales to meet security needs.

Advance your security maturity level using existing resources.

Turn security from a blocker into an enabler. Cisco SecureX allows you to add new security capabilities for the threat landscape.

Maximize your operational efficiency, helping you get the most from your security investments.

Reviews from Real Users

Below are some reviews and helpful feedback written by Cisco SecureX users.

PeerSpot user Wouter H., Technical Team Lead Network & Security at Missing Piece BV, shares several reasons why he thinks the solution is fantastic. In his opinion, “SecureX takes all the separate pieces of security within your company, adds in intelligence from different sites and services on the internet, and makes them work together. If an email is received on a machine and malware is being executed, it can be put into lockdown mode. The fact that you can have a single solution that combines endpoint intelligence with email intelligence, firewalls, and publicly available intelligence is really helpful. Also, SecureX provides us with contextual awareness throughout our security ecosystem. Before SecureX, things that were not possible, or that would take days, now literally take seconds to find out.

Michal S., Infrastructure Engineer at a media company, says, “SecureX provides many measurements and has a really good dashboard. Working with it you are able to see things very clearly and you have every detail on a single display. That saves us money and time.” He also adds, “It brings all our data into a central point. It also shows us many data connections between many of our environments. SecureX gives you really good information about potential risks. You are able to find the source of a risk, a potential risk from a user or a machine.”

Blair A., Technology Director at Shawnee Heights USD #450, explains, "One of the most valuable features is the simplicity of deploying SecureX. It's very easy to do that and then you gain very detailed visibility into everything that's going on in your network and, obviously, at the device level. There's just a wealth of information that you can pull from all of these products that are part of SecureX. You know exactly if you have an issue or not."

Cisco

Microsoft Defender XDR is a comprehensive security solution designed to protect against threats in the Microsoft 365 environment.

It offers robust security measures, comprehensive threat detection capabilities, and an efficient incident response system. With seamless integration with other Microsoft products and a user-friendly interface, it simplifies security management tasks.

Users have found it effective in detecting and preventing various types of attacks, such as phishing attempts, malware infections, and data breaches.

Watch the Microsoft demo video here: Microsoft Defender XDR demo video.

Microsoft

Sample Customers

CBI Health Group, University Honda, VakifBank

NHS, Rackspace, UNC Pembroke, University of North Carolina at Charlotte, Missing Piece

Accenture, Deloitte, ExxonMobil, General Electric, IBM, Johnson & Johnson and many others.

Buyer's Guide

Extended Detection and Response (XDR)

October 2026

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