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Microsoft Defender for Endpoint vs VirusTotal comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Apr 20, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Endp...
Ranking in Anti-Malware Tools
1st
Average Rating
8.2
Reviews Sentiment
7.1
Number of Reviews
197
Ranking in other categories
Endpoint Protection Platform (EPP) (1st), Advanced Threat Protection (ATP) (4th), Endpoint Detection and Response (EDR) (3rd), Microsoft Security Suite (4th)
VirusTotal
Ranking in Anti-Malware Tools
3rd
Average Rating
8.8
Reviews Sentiment
7.3
Number of Reviews
11
Ranking in other categories
Threat Intelligence Platforms (3rd)
 

Mindshare comparison

As of July 2025, in the Anti-Malware Tools category, the mindshare of Microsoft Defender for Endpoint is 15.6%, down from 21.0% compared to the previous year. The mindshare of VirusTotal is 5.1%, down from 6.8% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Anti-Malware Tools
 

Featured Reviews

Sudhen Swami - PeerSpot reviewer
Easy to update with good protection and a useful cloud portal
We've mainly used it for endpoints. However, we've also used it for DLP as well. We're also in the process of implementing it for cloud and identity as well. However, it's very good for endpoints, and that's our main focus. The malware protection is good. The visibility it provides is very useful. We can combine visibility with wider security features and alerts around malware, misconfiguration, or any other kinds of threats. The cloud portal is quite good. From there, we are able to see alerts and have colleagues review issues and monitor to see if any patterns arise. It's serving us quite well overall. It allows us to look at other items, like application and browser control. It helps us prioritize threats. We have a process in place now where we can review issues and remediate them effectively. We have been able to integrate a variety of Microsoft security products together. We use Azure AD, for example, and we've begun to implement DLP, among other items. We're looking at labeling and tagging and will expand into that soon. Defender has more stringent system requirements than, for example, Check Point. So when we implemented the Check Point Endpoint agent, that solution didn't mind what version of Windows you were using. When we moved to Defender, Defender had certain system prerequisites that had to be met. So we had to make sure that we're on a minimum version of Windows when we're utilizing Office, and Office has to be a particular version as well. It has more stringent system requirements that have to be met before you can implement it. It works natively together with other Microsoft solutions. Once you get more and more of those different components across the environment, then you start to get better visibility. So, rather than having lots of different solutions, you have fewer solutions and a single vendor solution. That way, you start getting into a position where you get better visibility and integration as well. The standardization is good. It's important. It's helping me with monitoring and learning. Updates and upgrades are quite smooth and seamless. Defender helps us automate routine tasks. Quite a lot of Microsoft is straightforward for us now. Previously, we didn't have enough resources and were unable to look at the alerts. Having this in place makes things a lot more straightforward for us. We have both the technology and the people in place now, alongside the process. We do see the benefits in that, and that's why we're continuing our adoption across the estate in terms of client and server as well. It's helping us avoid looking at multiple dashboards and centralized monitoring. We're not fully there yet. We're getting there. While we haven't witnessed time saving yet, once it's fully deployed, it will. By then, we'll have standardized processes across a single solution. We have saved money, however, as we continue to reduce non-Mircosft systems. Since we won't be using various competing technologies, we can save on licensing costs. We've likely so far saved 15%. While it's hard to estimate exactly how much, the solution has helped us decrease time to detection and time to respond.
Chinmay Banerjee - PeerSpot reviewer
Helps businesses collect threat data while keeping privacy in mind and apable of detecting, blocking, and removing viruses and malware
There are two gray areas I still need to explore. I have worked with VirusTotal because it easily integrates with over seventy antivirus scanners and blacklisting services. In addition to those there is much scope to improve and add other services or integrations. The areas for improvement are that VirusTotal is not using much AI or generative AI models, while other competitors are starting to build them. For example, VirusTotal's work is based on the setup done by their engineers. If you want to do scanning or protection activities for a specific site, app, or device, that is the area VirusTotal is currently focused on. But other competitors are building AI models that can do things like left-side scanning and provide auto-generated reports. VirusTotal has predefined reports, but there is a lot of manual effort involved. Secondly, the API is very limited if I want to integrate VirusTotal with other applications. They need to build more connectors and provide support for Webhook connectors for the API. If you can't build your own connector, it's always good to have provisions for Webhook setup connectors across platforms. Thirdly, Kaspersky, a competitor of VirusTotal, is using a methodology called "gatekeeper." A gatekeeper is a security system that protects the inside of a building from outside threats. This is the model Kaspersky is currently using. You have your website set up, but the entire army of VirusTotal or Kaspersky is standing guard, protecting you from the first gate itself. Right now, VirusTotal detects threats from your domain, but it is always better to verify inside the domain and protect it from the first level when people or malware are entering. This first level of protection is lacking in VirusTotal right now. The security bridge and protection gate are missing.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"I enjoy using the live response feature, which allows me to remotely access different endpoints and investigate malicious files, such as malware that people may have downloaded, and other related issues."
"It's really stable. I've used a lot of stuff, a lot of products, like ESET and Kaspersky. None of them are comparable with this one. This one is much better."
"The protection that it provides is quite good."
"We are a Microsoft shop, and Defender is a Microsoft solution that provides some security at a reasonable cost."
"Microsoft Defender for Endpoint is scalable. Currently, we have 600,000 users in our organization."
"It is quite stable. We have not had any cases, i.e., viruses, that would require a reboot, etc. We have never had a situation where we needed to reinstall the tools as a result of the Defender application or a feature being corrupt."
"The most valuable feature is that it comes with the package, so there is no additional installation of third-party software. It's also easy to use."
"Microsoft Defender is always running. It is doing its job, so it is fine. I don't have any issues with the way it was implemented or how we are running it. We have been upgrading IT throughout the years, but there have been no issues."
"VirusTotal provides 95% to 98% accurate information."
"With VirusTotal, I can check for any hash, malware, file, domain, IP URL, or malicious URL, and Kaspersky stays clean."
"It is quite simple for anyone if they just want to check some suspicious URLs."
"It allows us to see if there have been previous reports on certain indicators of compromise, providing insights from other security professionals."
"It provides detailed insights into possible malicious behavior, dropped files, and TCP connections."
"VirusTotal provides 95% to 98% accurate information."
"The initial setup is easy."
"The product is easy to use with coding, such as Python or Java, via its API."
 

Cons

"It would be helpful if they included XDR features, on top of the EDR functionality."
"The time it takes to implement policies has room for improvement."
"I would like MDE to have the ability to isolate a certain amount of time on the timeline."
"Sometimes, there are different skews. In a basic skew, they should have basic log analysis without the need to integrate with any third-party or SIEM solutions, like Sentinel. This would make it so much easier for users who don't have log collection or log analysis."
"This solution is not secure, which is why I have moved to Linux."
"It is currently more suitable for end-users rather than enterprises with lots of other processes and third-party tools. It needs improvement on that front. We had many issues while integrating it with our enterprise solutions, such as Splunk, and third-party tools. It provides everything via APIs. Other vendors provide integration with third-party tools, but Microsoft doesn't do that. It is also logging too much and is not serialized from the process aspect. It has all the data, but it is not in a proper format or not properly indexed, which doesn't make it easier for enterprises to use this data. Other vendors provide troubleshooting information that can be used to troubleshoot issues, but Microsoft doesn't provide anything like that."
"It can be more secure."
"Microsoft Defender for Endpoint should include better automation that will make it faster to detect the latest threats happening across the world."
"VirusTotal has predefined reports, but there is a lot of manual effort involved."
"I would like to see an improved user interface and some automation."
"VirusTotal is hard to understand because you need to know Google Docs to create queries, and it doesn't have documentation for that."
"There is room for improvement, particularly in making some of the most useful features more accessible in the non-paid version."
"They can improve the telemetry. Whenever we handle a sample, they cannot provide any information about a victim."
"There should be room for improvement, particularly in the API side of things."
"VirusTotal has different versions, and sometimes the parameters of the API are not very clear."
"I would like to see improvements in the score consistency and accuracy."
 

Pricing and Cost Advice

"It came with Windows."
"When customers haven't deployed the solution and don't have licenses, it can be expensive to start from scratch."
"Everybody would like to see a lower price on everything. The Slovenian market is basically an SME market with clients having up to 100 seat licenses, comprising 90% of the company. They're very price sensitive. So, the price could be cheaper."
"The price was a problem for me three years ago, but they improved their E3, E5, and a la carte licensing. In other words, you have to get all of E5. That used to be a problem because you had E3, Defender, and guardrails, but you needed an E5 license to get the management suite and the analytics. It's more flexible now. You can switch from a la carte to the entire suite when it starts to make sense. It's becoming more economically competitive to go that route."
"I recently switched from education to private business, and all I can say is that private business licensing from Microsoft is not cheap until you hit certain quantities or scale. That does not mean that it is not comparable to other industries. It is similar pricing, but it is still crazy to me how much you pay for a client. I feel it is high, but it is in line with other vendors."
"The license for Microsoft Defender for Endpoint is included in the license for the Microsoft Windows operating system."
"You need a license to use this solution."
"If you don't purchase the advanced threat protection then there is no additional charge."
"VirusTotal is an expensive solution."
"We are using VirusTotal with free licenses, managing the license limits across three or four accounts, thus incurring no costs."
"The pricing is reasonable."
"The pricing is very economical."
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Top Industries

By visitors reading reviews
Educational Organization
14%
Computer Software Company
13%
Government
8%
Financial Services Firm
8%
Computer Software Company
19%
Financial Services Firm
8%
Government
8%
University
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface, applies behavioral-based endpoint protection and response, and includes risk-ba...
Which offers better endpoint security - Symantec or Microsoft Defender?
We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior solution. Microsoft Defender for Endpoint is a cloud-delivered endpoint security s...
How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?
The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never push your machine hardware to "test", you don't have the usual "scan now" feature ...
What do you like most about VirusTotal?
With VirusTotal, I can check for any hash, malware, file, domain, IP URL, or malicious URL, and Kaspersky stays clean.
What is your experience regarding pricing and costs for VirusTotal?
I do not know about the pricing or licensing as our organization services VirusTotal for our clients.
What needs improvement with VirusTotal?
I would like to see improvements in the score consistency and accuracy. VirusTotal should add more details like those from competitors such as URL Void or Symantec URL Checker, which show the categ...
 

Also Known As

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus
No data available
 

Interactive Demo

Demo not available
 

Overview

 

Sample Customers

Petrofrac, Metro CSG, Christus Health
Information Not Available
Find out what your peers are saying about Microsoft Defender for Endpoint vs. VirusTotal and other solutions. Updated: June 2025.
860,592 professionals have used our research since 2012.