Microsoft Defender for Endpoint vs VirusTotal comparison

Microsoft Defender for Endp...

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Executive SummaryUpdated on Nov 2, 2025

VirusTotal and Microsoft Defender for Endpoint are complementary cybersecurity products. Microsoft Defender for Endpoint has an edge in overall security performance due to its comprehensive endpoint protection capabilities.

Features: VirusTotal offers quick threat identification with a wide range of antivirus engines and URL scanners. It allows competitive landscape analysis against different antivirus solutions. Microsoft Defender for Endpoint, however, includes advanced threat protection features such as automatic malware scanning, centralized management, and integration with Microsoft cloud services.

Room for Improvement: VirusTotal could improve by adding more support options and expanding its service integrations. It lacks deep support features for businesses seeking holistic security operations. Microsoft Defender for Endpoint can enhance user education and support for wider platform compatibility.

Ease of Deployment and Customer Service: Microsoft Defender benefits from seamless integration into Microsoft environments, simplifying deployment and offering extensive support resources. VirusTotal, as a web-based tool, has a straightforward deployment process but doesn’t offer in-depth support options. Microsoft Defender suits businesses seeking integrated support.

Pricing and ROI: VirusTotal is cost-effective with no setup fees and is ideal for smaller operations needing basic threat detection. Microsoft Defender requires a higher initial investment but provides significant ROI through extensive endpoint protection features and reduced vulnerability risks, justifying its higher cost for businesses looking for comprehensive security solutions.

To learn more, read our detailed Microsoft Defender for Endpoint vs. VirusTotal Report (Updated: December 2025).

Microsoft Defender for Endpoint vs. VirusTotal

December 2025

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Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Categories and Ranking

Microsoft Defender for Endp...

Ranking in Anti-Malware Tools

1st

Average Rating

8.2

Reviews Sentiment

7.0

Number of Reviews

210

Ranking in other categories

Endpoint Protection Platform (EPP) (2nd), Advanced Threat Protection (ATP) (3rd), Endpoint Detection and Response (EDR) (3rd), Microsoft Security Suite (3rd)

VirusTotal

Ranking in Anti-Malware Tools

4th

Average Rating

8.8

Reviews Sentiment

7.3

Number of Reviews

Ranking in other categories

Threat Intelligence Platforms (TIP) (3rd)

Mindshare comparison

As of January 2026, in the Anti-Malware Tools category, the mindshare of Microsoft Defender for Endpoint is 9.1%, down from 17.7% compared to the previous year. The mindshare of VirusTotal is 3.5%, down from 5.1% compared to the previous year. It is calculated based on PeerSpot user engagement data.

Anti-Malware Tools Market Share Distribution
Product	Market Share (%)
Microsoft Defender for Endpoint	9.1%
VirusTotal	3.5%
Other	87.4%

Anti-Malware Tools

Featured Reviews

Robert Arbuckle

Security Analyst III at a healthcare company with 10,001+ employees

Automatically isolates threats and integrates with logging to reduce response time

Overall, I would evaluate the Microsoft support level that I receive at probably about a seven, but that depends on the day. It has been spotty. We have had issues where the urgency level of the Microsoft support is not as high as ours, especially during a data breach or potential data breach situation. We have had issues with some of the offshore support being lackluster. One specific thing that comes to mind is we were on a support call with our CISO on the call, and the Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, "Just to set expectations, my lunch break is in an hour and I am going to go away then." For us, it was already ten o'clock at night and we had been working on this for a couple of hours, trying to get a security engineer on with us. For him to tell us that he was going to go away and have lunch, it was, "Okay, but go find somebody else if you need to." It was just the lackluster approach, and it seemed like he did not really care. We seem to get a lot of this when we get non-Microsoft support. I can identify areas for improvement with Microsoft Defender for Endpoint, as it is kind of a convoluted mess to try to take care of false positives. Especially when they have been identified as false positives but they keep going off over and over again. It is great for my pocketbook because it generates a lot of on-call action, but I would really prefer more sleep at two o'clock in the morning than dealing with false positives. I would say that the unified portal for managing Microsoft Defender for Endpoint is suitable for both teams as they are all in there. It would be great if they would stop moving things around and renaming things, which makes sense. The new XDR portal is pretty nice. Being able to have it central again inside of the regular Security Center without having to open up two windows is helpful. Overall, I think it is pretty good. There is always going to be something that could be improved, such as alerting and the ability to modify alerts would be a little bit helpful to have. Being able to add more data into the alerts and turn off alerts that are not as useful would be beneficial. It is hard to say what the quantitative impact the security exposure management feature has had on our company's security, because a lot of it is kind of subjective. I think we are sitting at around a fifty percent score still, and a lot of it is just kind of unusual circumstances that we cannot really implement without breaking the organization.

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Chinmay Banerjee

Advisor Adtech/Martech/API product/project Engineering at a financial services firm with 10,001+ employees

Helps businesses collect threat data while keeping privacy in mind and apable of detecting, blocking, and removing viruses and malware

There are two gray areas I still need to explore. I have worked with VirusTotal because it easily integrates with over seventy antivirus scanners and blacklisting services. In addition to those there is much scope to improve and add other services or integrations. The areas for improvement are that VirusTotal is not using much AI or generative AI models, while other competitors are starting to build them. For example, VirusTotal's work is based on the setup done by their engineers. If you want to do scanning or protection activities for a specific site, app, or device, that is the area VirusTotal is currently focused on. But other competitors are building AI models that can do things like left-side scanning and provide auto-generated reports. VirusTotal has predefined reports, but there is a lot of manual effort involved. Secondly, the API is very limited if I want to integrate VirusTotal with other applications. They need to build more connectors and provide support for Webhook connectors for the API. If you can't build your own connector, it's always good to have provisions for Webhook setup connectors across platforms. Thirdly, Kaspersky, a competitor of VirusTotal, is using a methodology called "gatekeeper." A gatekeeper is a security system that protects the inside of a building from outside threats. This is the model Kaspersky is currently using. You have your website set up, but the entire army of VirusTotal or Kaspersky is standing guard, protecting you from the first gate itself. Right now, VirusTotal detects threats from your domain, but it is always better to verify inside the domain and protect it from the first level when people or malware are entering. This first level of protection is lacking in VirusTotal right now. The security bridge and protection gate are missing.

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Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Pros

"A few years ago, when I was using a different product, I was affected by a virus that destroyed everything. Since using Microsoft Defender, I have not had this kind of problem."

"We can react to threats faster and stop them from spreading from one machine to another. It protects from suspicious email attachment downloads. It will lock down the SOC and the workstations."

"Easy to understand and easy to set up endpoint security solution. It's a multifeatured product with web content filtering and automated investigation features. It also has a fantastic vulnerability management dashboard."

"There are some competitive products on the market, but the best is Microsoft Defender because it's very easy to integrate. That's one reason a lot of clients want Microsoft Defender. It's also very easy to implement compared to other solutions."

"Defender is stable, I haven't had any problems with viruses when using it, and it's easy to update."

"It is easy to install and use requiring little maintenance but applying updates."

"Defender's analytics are much better than CrowdStrike's."

"Microsoft Defender for Endpoint comes pre-installed in Microsoft Windows."

More Microsoft Defender for Endpoint pros

"It can scan the dark web and find if an email ID has been compromised. This is another area that we have not explored yet."

"It provides detailed insights into possible malicious behavior, dropped files, and TCP connections."

"VirusTotal provides 95% to 98% accurate information."

"It is quite simple for anyone if they just want to check some suspicious URLs."

"I have never had any problems with stability or bugs while using VirusTotal."

"VirusTotal provides 95% to 98% accurate information."

"The product is easy to use with coding, such as Python or Java, via its API."

"The initial setup is easy."

More VirusTotal pros

Cons

"The anti-ransomware features need to be improved upon."

"I would like to be able to set up any kind of protection I want in the firewall, any IP address or any number."

"Microsoft Defender could be improved with features more like the McAfee ePO. It would be better if I had a console to get all the information for my endpoints. Maybe this is too much for it, but it would be better if it could handle those non-signature-based malicious codes or viruses."

"If they integrate with the EDR then it will benefit this solution."

"Additional security would be beneficial."

"Auto recovery is the most important feature that we would need from this solution. For decryption, similar to Malwarebytes, there should be something to be able to recover the data up to the last normal status. Its ability to recover data to the last normal copy must not exceed 5 to 10 minutes."

"With increase of cyber threats and cybersecurity issues, I would recommend that the product be developed like an AI product with more features which can counter any threat in the coming eras."

"I want Microsoft Defender to have the ability to deal with some issues automatically, so I don't need to address that issue manually."

More Microsoft Defender for Endpoint cons

"VirusTotal has predefined reports, but there is a lot of manual effort involved."

"VirusTotal has different versions, and sometimes the parameters of the API are not very clear."

"I would like to see improvements in the score consistency and accuracy."

"The platform could improve in the areas of endpoints and networks."

"VirusTotal is hard to understand because you need to know Google Docs to create queries, and it doesn't have documentation for that."

"I would like to see improved correlation with other threat intelligence sources, not just reliant on its own database, to enhance the database of threat intelligence that VirusTotal offers."

"They can improve the telemetry. Whenever we handle a sample, they cannot provide any information about a victim."

More VirusTotal cons

Pricing and Cost Advice

"It is so expensive. It isn't cheaper than McAfee or other solutions."

"We have seen ROI. Most of the other competing alternatives will cost up to around $30 per user device. We average 400 devices. Therefore, the amount that we save each year is 400 times $30."

"For me, the pricing is very good, but for management it's very expensive. Other solutions are less expensive. But when I present all the information and all the reports they say, "Well, it's expensive, but the cost-benefit is very good.""

"The solution comes as part of Microsoft Windows."

"We pay a yearly license for Microsoft Defender. We also have a support contract with them."

"This solution is part of Windows and comes included with it."

"I do not have to purchase antivirus solutions anymore because Microsoft Defender for Endpoint is integrated into Windows and comes free."

"It came with Windows."

More Microsoft Defender for Endpoint pricing and cost advice

"The pricing is reasonable."

"VirusTotal is an expensive solution."

"The pricing is very economical."

"We are using VirusTotal with free licenses, managing the license limits across three or four accounts, thus incurring no costs."

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Top Industries

By visitors reading reviews

No data available

Computer Software Company

14%

Financial Services Firm

10%

Comms Service Provider

University

Company Size

By reviewers

Large Enterprise

Midsize Enterprise

Small Business

By reviewers
Company Size	Count
Small Business	80
Midsize Enterprise	40
Large Enterprise	92

By reviewers
Company Size	Count
Small Business	4
Midsize Enterprise	2
Large Enterprise	5

Questions from the Community

How is Cortex XDR compared with Microsoft Defender?

Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface, applies behavioral-based endpoint protection and response, and includes risk-ba...

Which offers better endpoint security - Symantec or Microsoft Defender?

We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior solution. Microsoft Defender for Endpoint is a cloud-delivered endpoint security s...

How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?

The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never push your machine hardware to "test", you don't have the usual "scan now" feature ...

What is your experience regarding pricing and costs for VirusTotal?

I do not know about the pricing or licensing as our organization services VirusTotal for our clients.

What needs improvement with VirusTotal?

I would like to see improvements in the score consistency and accuracy. VirusTotal should add more details like those from competitors such as URL Void or Symantec URL Checker, which show the categ...

What is your primary use case for VirusTotal?

As I work in an incident response role, my daily task is to mitigate the security alert and perform the analysis part. When any alerts come, I check the IPs from where they originate and the locati...

HP Wolf Security vs Microsoft Defender for Endpoint

Comparisons

Compared 5% of the time

Symantec Endpoint Security vs Microsoft Defender for Endpoint

Compared 5% of the time

CrowdStrike Falcon vs Microsoft Defender for Endpoint

Compared 4% of the time

F-Secure Total vs Microsoft Defender for Endpoint

Compared 4% of the time

Cortex XDR by Palo Alto Networks vs Microsoft Defender for Endpoint

Compared 3% of the time

More Microsoft Defender for Endpoint Competitors

MetaDefender vs VirusTotal

Compared 12% of the time

ANY.RUN vs VirusTotal

Compared 9% of the time

Recorded Future vs VirusTotal

Compared 6% of the time

OPSWAT Filescan Sandbox vs VirusTotal

Compared 6% of the time

Cuckoo Sandbox vs VirusTotal

Compared 6% of the time

More VirusTotal Competitors

Product Reports

Microsoft Defender for Endpoint

January 2026

Download Microsoft Defender for Endpoint product report

Download VirusTotal product report

Anti-Malware Tools

January 2026

Also Known As

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus

No data available

Interactive Demo

Microsoft

Demo not available

Overview

Microsoft Defender for Endpoint is a comprehensive security solution that provides advanced threat protection for organizations. It offers real-time protection against various types of cyber threats, including malware, viruses, ransomware, and phishing attacks.

With its powerful machine-learning capabilities, it can detect and block sophisticated attacks before they can cause any harm. The solution also includes endpoint detection and response (EDR) capabilities, allowing organizations to quickly investigate and respond to security incidents. It provides detailed insights into the attack timeline, enabling security teams to understand the scope and impact of an incident.

Microsoft Defender for Endpoint also offers proactive threat hunting, allowing organizations to proactively search for and identify potential threats within their network. It integrates seamlessly with other Microsoft security solutions, such as Microsoft Defender XDR, to provide a unified and holistic security approach. With its centralized management console, organizations can easily deploy, configure, and monitor the security solution across their entire network.

Microsoft Defender for Endpoint is a robust and scalable security solution that helps organizations protect their endpoints and data from evolving cyber threats.

Microsoft

VirusTotal provides a comprehensive digital security platform by leveraging a vast malware database. It integrates numerous antivirus scanners for robust malware and virus detection, offering valuable insights for threat intelligence and security analysis.

VirusTotal is widely used for malware analysis and cybersecurity investigations, relying on its extensive capabilities in file and IP analysis. It integrates seamlessly with various antivirus engines, ensuring detailed threat intelligence. The platform excels at performing automated reputation checks, gleaning insights from a robust community, and delivering comprehensive information on suspicious activities. With an API system, it facilitates deeper analysis and integration into existing security workflows.

What are the standout features of VirusTotal?

Vast Malware Database: A comprehensive repository for malware intelligence.
Integration with Antivirus Scanners: Collaborates with multiple scanners for enhanced detection.
File and IP Analysis: Detailed insights into files and IP addresses.
Automated Reputation Checks: Efficiently verifies file and domain safety.
Community Insights: Gathers valuable data from an active community.

What benefits and ROI should be considered?

Threat Intelligence: Informs strategic security decisions with detailed malware data.
Enhanced Detection: Supports comprehensive threat identification and response.
Contextual Analysis: Provides extensive details for thorough investigation of threats.

In sectors like retail, FinTech, and GRC, VirusTotal is integrated into cybersecurity workflows to enhance incident response capabilities. It is invaluable for analyzing phishing websites, inspecting URLs, identifying compromised information, and generating alerts for specific threats. APIs enable deeper examination of suspicious activity, supporting comprehensive cybersecurity operations.

Sample Customers

Petrofrac, Metro CSG, Christus Health

Information Not Available