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Microsoft Defender for Endpoint vs Palo Alto Networks VM-Series comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
6.9
Microsoft Defender for Endpoint offers significant ROI with cost savings, seamless integration, and real-time protection against ransomware attacks.
Sentiment score
5.7
Palo Alto Networks VM-Series delivers strong ROI through enhanced security, rapid deployment, and significant time savings despite high pricing.
Without detection and protection measures, organizations would face substantial payments and reputational damage, including the necessity to inform customers about data breaches, potentially leading to loss of business.
Consultant at ACT4SERVICES
We have seen a return on investment when using Microsoft Defender for Endpoint, as it saves labor by reducing the need for staff to focus on it.
IT CONSULTANT at a tech company with 10,001+ employees
The biggest return on investment for me when using Microsoft Defender for Endpoint is the time saving.
Lead security engineer at a computer software company with 11-50 employees
Customers can see data within a week, indicating a quick return on investment.
Senior Manager Technical Security at Hitachi Systems, Ltd.
 

Customer Service

Sentiment score
6.4
Many users find Microsoft Defender for Endpoint reliable, but support experiences vary, with premium support offering quicker assistance.
Sentiment score
7.5
Customers appreciate Palo Alto Networks VM-Series support for responsiveness and expertise, despite occasional delays and high premium service costs.
The Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, 'Just to set expectations, my lunch break is in an hour and I am going to go away then.'
Security Analyst III at a healthcare company with 10,001+ employees
The level-one support seems disconnected from subject matter experts.
Office 365 Subject Expert at a government with 10,001+ employees
I rate Microsoft support 10 out of 10.
Team manager of it department at a financial services firm with 501-1,000 employees
The support quality could be improved.
Senior Manager Technical Security at Hitachi Systems, Ltd.
Resolving issues promptly.
Head of Sales at Omgea Exim Ltd
They are responsive and provide high-quality assistance.
Cyber security consultant at L&T Technology Services
 

Scalability Issues

Sentiment score
7.4
Microsoft Defender for Endpoint is scalable and integrates well with Microsoft’s ecosystem, despite needing improvements for handling massive data.
Sentiment score
7.4
Palo Alto Networks VM-Series is scalable, easy to deploy, and suits businesses with positive feedback on flexibility and growth.
We managed to scale it out in a short amount of time, with two months of planning and three months of implementation on 10,000 computers.
Team manager of it department at a financial services firm with 501-1,000 employees
Microsoft Defender for Endpoint is scalable enough to handle various devices across environments, whether they are laptops, Android devices, or operating in hybrid environments.
Snr. Infrastructure Architect (Data Centre) at LogicEra
Compatibility is its main feature.
IT CONSULTANT at a tech company with 10,001+ employees
They are easy to upgrade, and with credit licensing, they scale effectively according to demand.
Security Technical Lead at a tech services company with 11-50 employees
The solution is scalable and can easily handle an increase in the number of users.
Cyber security consultant at L&T Technology Services
It is easy to use with an excellent graphical user interface and extensive documentation, which contributes to its high scalability.
Senior Security Consultant at Netsecurity.no
 

Stability Issues

Sentiment score
7.9
Microsoft Defender for Endpoint is praised for its reliability and stability, with minor concerns about resource intensity and performance.
Sentiment score
8.2
Palo Alto Networks VM-Series is highly regarded for stability, reliable performance, and consistent uptime, despite minor navigation delays.
I haven't seen any outages with Microsoft.
IT Security Engineer at a financial services firm with 1,001-5,000 employees
I rate Defender 10 out of 10 for stability.
Team manager of it department at a financial services firm with 501-1,000 employees
Defender for Endpoint is extremely stable.
Systems engineers at Delta Dental of Colorado
Hardware is generally very stable.
Security Technical Lead at a tech services company with 11-50 employees
I have not experienced any major problems or downtime.
Senior IT Infrastructure Specialist at contemi
Perfection is unlikely as the dynamic nature of traffic and constant changes can result in occasional bugs despite regular updates.
Senior Security Consultant at Netsecurity.no
 

Room For Improvement

Microsoft Defender for Endpoint faces interface complexity, slow detection, high CPU usage, integration issues, and seeks improvements in multiple areas.
Palo Alto Networks VM-Series needs UI updates, better platform integration, scalability, user-friendliness, and improved documentation for broader efficiency.
Repeated interactions are necessary due to Level One's lack of tools and knowledge, hindering efficient problem-solving and negatively impacting our experience with Microsoft support.
Office 365 Subject Expert at a government with 10,001+ employees
In contrast, competing products offer reduced pricing for long-term commitments, which makes it difficult for us in that environment.
Solution Consultant at BIM Group of Companies
We use Microsoft partners to help govern the platform, and as part of an alliance, we want to gather data from each tenant and combine them for a complete view.
Team manager of it department at a financial services firm with 501-1,000 employees
Integration with CSIRT across all use levels would make it easier for administrators to stay updated on the blocked entities without manual intervention.
Cyber security consultant at L&T Technology Services
Most customers go for partner-enabled support, which involves multiple layers, leading to delays.
Security Technical Lead at a tech services company with 11-50 employees
Having those features missing, we are not proposing Palo Alto Networks VM-Series to all customers.
Sr. Network Engineer at a tech services company with 1-10 employees
 

Setup Cost

Microsoft Defender for Endpoint offers flexible pricing, making it competitive and cost-effective compared to standalone security products.
Palo Alto VM-Series is costly but reliable, with complex licensing; AWS Marketplace offers scalable subscription options.
That has been the trend we have seen with Microsoft lately—it is just getting more and more expensive.
Assistant Director, Hybrid Infrastructure & Operations at a insurance company with 501-1,000 employees
Given our extensive Microsoft licensing, transitioning to Defender for Endpoint did not affect licensing costs.
Team manager of it department at a financial services firm with 501-1,000 employees
It costs $15 per VM for the P2 plan, which is seen as affordable for customers.
Snr. Infrastructure Architect (Data Centre) at LogicEra
Palo Alto is expensive in terms of pricing, particularly when comparing features to cost.
Security Technical Lead at a tech services company with 11-50 employees
The cost involves purchasing through a vendor, which might mark up due to the supply chain.
Senior IT Infrastructure Specialist at contemi
Pricing for Palo Alto Networks is higher than other OEMs, but considering the robustness and features, it gains customer trust.
Head of Sales at Omgea Exim Ltd
 

Valuable Features

Microsoft Defender for Endpoint excels with seamless integration, advanced threat intelligence, AI-driven protection, and continuous cloud-based security management.
The VM-Series provides scalable, flexible security with advanced threat management, visibility, and integration features, enhancing network protection.
Defender for Endpoint's coverage across different platforms in our environment is pretty good. We have devices running Linux, Mac OS, Windows, iOS, and Android. It covers all of them.
Team manager of it department at a financial services firm with 501-1,000 employees
Microsoft Defender for Endpoint provides a unified management interface allowing customers to manage their on-premises and hybrid infrastructures from a single pane.
Snr. Infrastructure Architect (Data Centre) at LogicEra
One of the best features of Microsoft Defender for Endpoint is its database for identifying zero-day attacks or malware attacks.
Consultant at ACT4SERVICES
We use these tools to prevent all known and unknown threats using Palo Alto Networks' Wildfire and other data filtering tools to gather information, analyze traffic, manage malicious traffic, and offer visibility, control, and attack prevention.
Senior Manager Technical Security at Hitachi Systems, Ltd.
Palo Alto's robust threat intelligence supports new updates, and I can open cases directly with their Threat Intelligence team.
Security Technical Lead at a tech services company with 11-50 employees
The DNS security significantly enhances security through visibility and detection, allowing control over crucial traffic like DNS, which is often exploited by ransomware.
Senior Security Consultant at Netsecurity.no
 

Categories and Ranking

Microsoft Defender for Endp...
Ranking in Advanced Threat Protection (ATP)
3rd
Average Rating
8.2
Reviews Sentiment
7.0
Number of Reviews
210
Ranking in other categories
Endpoint Protection Platform (EPP) (2nd), Anti-Malware Tools (1st), Endpoint Detection and Response (EDR) (3rd), Microsoft Security Suite (3rd)
Palo Alto Networks VM-Series
Ranking in Advanced Threat Protection (ATP)
11th
Average Rating
8.6
Reviews Sentiment
6.9
Number of Reviews
66
Ranking in other categories
Firewalls (12th)
 

Mindshare comparison

As of February 2026, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Endpoint is 5.7%, down from 7.8% compared to the previous year. The mindshare of Palo Alto Networks VM-Series is 2.2%, up from 1.3% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
Microsoft Defender for Endpoint5.7%
Palo Alto Networks VM-Series2.2%
Other92.1%
Advanced Threat Protection (ATP)
 

Featured Reviews

Robert Arbuckle - PeerSpot reviewer
Security Analyst III at a healthcare company with 10,001+ employees
Automatically isolates threats and integrates with logging to reduce response time
Overall, I would evaluate the Microsoft support level that I receive at probably about a seven, but that depends on the day. It has been spotty. We have had issues where the urgency level of the Microsoft support is not as high as ours, especially during a data breach or potential data breach situation. We have had issues with some of the offshore support being lackluster. One specific thing that comes to mind is we were on a support call with our CISO on the call, and the Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, "Just to set expectations, my lunch break is in an hour and I am going to go away then." For us, it was already ten o'clock at night and we had been working on this for a couple of hours, trying to get a security engineer on with us. For him to tell us that he was going to go away and have lunch, it was, "Okay, but go find somebody else if you need to." It was just the lackluster approach, and it seemed like he did not really care. We seem to get a lot of this when we get non-Microsoft support. I can identify areas for improvement with Microsoft Defender for Endpoint, as it is kind of a convoluted mess to try to take care of false positives. Especially when they have been identified as false positives but they keep going off over and over again. It is great for my pocketbook because it generates a lot of on-call action, but I would really prefer more sleep at two o'clock in the morning than dealing with false positives. I would say that the unified portal for managing Microsoft Defender for Endpoint is suitable for both teams as they are all in there. It would be great if they would stop moving things around and renaming things, which makes sense. The new XDR portal is pretty nice. Being able to have it central again inside of the regular Security Center without having to open up two windows is helpful. Overall, I think it is pretty good. There is always going to be something that could be improved, such as alerting and the ability to modify alerts would be a little bit helpful to have. Being able to add more data into the alerts and turn off alerts that are not as useful would be beneficial. It is hard to say what the quantitative impact the security exposure management feature has had on our company's security, because a lot of it is kind of subjective. I think we are sitting at around a fifty percent score still, and a lot of it is just kind of unusual circumstances that we cannot really implement without breaking the organization.
AV
Cyber security consultant at L&T Technology Services
Enhance cybersecurity for large enterprises using advanced threat management
An improvement could be the integration of security intelligence with Palo Alto cloud via APIs. This would allow IOCs, domains, and hash values to be automatically entered, reducing manual entry. Integration with CSIRT across all use levels would make it easier for administrators to stay updated on the blocked entities without manual intervention.
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Top Industries

By visitors reading reviews
Computer Software Company
10%
Manufacturing Company
9%
Financial Services Firm
8%
Government
8%
Computer Software Company
11%
Financial Services Firm
10%
Manufacturing Company
10%
University
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business80
Midsize Enterprise40
Large Enterprise92
By reviewers
Company SizeCount
Small Business29
Midsize Enterprise17
Large Enterprise24
 

Questions from the Community

How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface, applies behavioral-based endpoint protection and response, and includes risk-ba...
Which offers better endpoint security - Symantec or Microsoft Defender?
We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior solution. Microsoft Defender for Endpoint is a cloud-delivered endpoint security s...
How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?
The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never push your machine hardware to "test", you don't have the usual "scan now" feature ...
Features comparison between Palo Alto and Fortinet firewalls
In the best tradition of these questions, Feature-wise both are quite similar, but each has things it's better at, it kind of depends what you value most. PA is good at app control, web filtering a...
How does Azure Firewall compare with Palo Alto Networks VM Series?
Both products are very stable and easily scalable. The setup of Azure Firewall is easy and very user-friendly and the overall cost is reasonable. Azure Firewall offers a solid threat awareness, can...
 

Also Known As

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus
No data available
 

Interactive Demo

Demo not available
 

Overview

 

Sample Customers

Petrofrac, Metro CSG, Christus Health
Warren Rogers Associates
Find out what your peers are saying about Microsoft Defender for Endpoint vs. Palo Alto Networks VM-Series and other solutions. Updated: February 2026.
881,821 professionals have used our research since 2012.