Microsoft Defender for Endpoint vs Qualys Multi-Vector EDR comparison

Microsoft and Qualys are both solutions in the Endpoint Detection and Response (EDR) category. Microsoft is ranked #3 with an average rating of 8.4, while Qualys is ranked #74. Microsoft holds a 6.0% mindshare in EDR, compared to Qualys’s 0.3% mindshare. Additionally, 95% of Microsoft users are willing to recommend the solution, compared to 100% of Qualys users who would recommend it.

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Executive Summary

We performed a comparison between Microsoft Defender for Endpoint and Qualys Multi-Vector EDR based on real PeerSpot user reviews.

Find out what your peers are saying about CrowdStrike, SentinelOne, Microsoft and others in Endpoint Detection and Response (EDR).

To learn more, read our detailed Endpoint Detection and Response (EDR) Report (Updated: April 2026).

Buyer's Guide

Endpoint Detection and Response (EDR)

April 2026

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Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Categories and Ranking

Cortex XDR by Palo Alto Net...

Mindshare comparison

As of May 2026, in the Endpoint Detection and Response (EDR) category, the mindshare of Cortex XDR by Palo Alto Networks is 3.4%, down from 4.0% compared to the previous year. The mindshare of Microsoft Defender for Endpoint is 6.0%, down from 10.7% compared to the previous year. The mindshare of Qualys Multi-Vector EDR is 0.3%, up from 0.2% compared to the previous year. It is calculated based on PeerSpot user engagement data.

Endpoint Detection and Response (EDR) Mindshare Distribution
Product	Mindshare (%)
Microsoft Defender for Endpoint	6.0%
Cortex XDR by Palo Alto Networks	3.4%
Qualys Multi-Vector EDR	0.3%
Other	90.3%

Endpoint Detection and Response (EDR)

Featured Reviews

ABHISHEK_SINGH

Senior Process Expert at A.P. Moller - Maersk

Gained full visibility and streamlined threat detection through behavior-based insights and AI integration

Initially, we got to have a lot of false positives when we onboarded, but nowadays it's quite smooth. We have fine-tuned our security policies and allowed different levels of policies to get rid of those false positives. Currently, we are getting a fairly good amount of incidents that are not false positives or benign, but actionable items. The process is streamlined. In the initial days, the operations used to get involved in a lot of benign and other activities, but now the process is streamlined. We are leveraging the auto-detection and remediation plans. The operations teams are now more involved in other business roles as well, not just looking into the logs and fetching out what's happening there. They have fixed a lot of things. Initially, they didn't have IAC code drift detection, cloud posture management, or security posture management, but they have those now. They purchased different vendors and did a merger with that. They have now Prisma Cloud that gets integrated and now they are working with Cortex Cloud. Everything that was negative has now been addressed, and the product altogether looks to be in a very better and mature shape now. Currently, it's more or less detecting the workloads with AI-based best practices. Since most organizations are consuming AI agents and other things, we are looking forward to seeing what other feature enhancements Palo Alto can support in that.

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Robert Arbuckle

Security Analyst III at a healthcare company with 10,001+ employees

Automatically isolates threats and integrates with logging to reduce response time

Overall, I would evaluate the Microsoft support level that I receive at probably about a seven, but that depends on the day. It has been spotty. We have had issues where the urgency level of the Microsoft support is not as high as ours, especially during a data breach or potential data breach situation. We have had issues with some of the offshore support being lackluster. One specific thing that comes to mind is we were on a support call with our CISO on the call, and the Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, "Just to set expectations, my lunch break is in an hour and I am going to go away then." For us, it was already ten o'clock at night and we had been working on this for a couple of hours, trying to get a security engineer on with us. For him to tell us that he was going to go away and have lunch, it was, "Okay, but go find somebody else if you need to." It was just the lackluster approach, and it seemed like he did not really care. We seem to get a lot of this when we get non-Microsoft support. I can identify areas for improvement with Microsoft Defender for Endpoint, as it is kind of a convoluted mess to try to take care of false positives. Especially when they have been identified as false positives but they keep going off over and over again. It is great for my pocketbook because it generates a lot of on-call action, but I would really prefer more sleep at two o'clock in the morning than dealing with false positives. I would say that the unified portal for managing Microsoft Defender for Endpoint is suitable for both teams as they are all in there. It would be great if they would stop moving things around and renaming things, which makes sense. The new XDR portal is pretty nice. Being able to have it central again inside of the regular Security Center without having to open up two windows is helpful. Overall, I think it is pretty good. There is always going to be something that could be improved, such as alerting and the ability to modify alerts would be a little bit helpful to have. Being able to add more data into the alerts and turn off alerts that are not as useful would be beneficial. It is hard to say what the quantitative impact the security exposure management feature has had on our company's security, because a lot of it is kind of subjective. I think we are sitting at around a fifty percent score still, and a lot of it is just kind of unusual circumstances that we cannot really implement without breaking the organization.

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reviewer1668453

Director, Security Innovation at a insurance company with 10,001+ employees

Provides contextual alerts and risk ratings on findings

It's kind of difficult to quantify areas for improvement. In the larger picture, one challenge is that the NDR space is very crowded today. I can mention half a dozen names just off the top of my head. There are at least 12 to 20 different players. All of them are well-known brand names, and it's difficult to compare them. They all claim to be giving you the same network difference capability: catching malware, dealing with all the minor taxonomy of attack, all that. Still, it's very difficult to compare them side by side because they all do things a little differently, and they all have different presentations and output. We haven't deployed it, so I can't give you what we felt about it exactly. But in the larger perspective, the critical feature is really giving a clear separation between a low, high, and medium criticality. You need a rating that is really true to the actual attack. There's one other capability we are evaluating them for, and it's for custom alerts detection. A lot of these products are trying to profile the threats that are already out there in the industry. They're very well known and published. Today, there are targeted acts being played against organizations, so you have to be sensitive to how your firewalls, protocols, and your HTTP are all operating. You might have some fine-tuned threats that are targeting you, and you should be able to build custom defenses. They should have some openness in terms of how you specify your threats. You get a standard library of threats. On top of it, every organization builds its own.

Read full review

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Pros

"After installing this solution, it identified, blocked, and provided the complete attack chain, which was very helpful."

"If any application performs suspicious activities, such as changing registries or modifying other applications, Cortex XDR detects and blocks the entire application."

"The tool is designed to scale for large enterprises and handle large volumes of data."

"The management capabilities, allow an IT organization to get quite a good picture of attempted cyber attacks."

"Cortex is the best solution for avoiding security breaches, malware attacks, and other kinds of security issues."

"Technical support is the best in class, in my opinion, because they have invested heavily in research and development."

"It collects and caches and the knowledge of machine learning from different customers to take to the cloud. It makes it better to use for everybody. It allows for quick learning and updates and can, therefore, offer zero-day malware security. This sharing of metadata helps make the solution very safe."

"The product is mostly automated, and we do not have to make decisions, because all the decisions are made by the product itself and we are not required to create any custom policies since the policies that are created are well defined in the product itself."

More Cortex XDR by Palo Alto Networks pros

"Our clients are definitely seeing an ROI."

"We can react to threats faster and stop them from spreading from one machine to another. It protects from suspicious email attachment downloads. It will lock down the SOC and the workstations."

"The whole bundle of the product, which is similar to other Microsoft products, is valuable. Ten years ago, you had third-party stuff for different things. You had one solution for email archiving and another third-party one for something else. Nowadays, Microsoft Office covers all the stuff that was formerly covered by third-party solutions. It is the same with antivirus. The functionality is just basic. You have the scanning, and then you also have a kind of cloud-based protection and reporting about your environment. With Microsoft Security Center, you have a complete overview of your environment. You know the software inventory, and you have security recommendations. You can not only see that the antivirus is up to date; you can also see where are the vulnerabilities in your system. Microsoft Security Center tells you where you have old, deprecated software and what kind of CVEs are addressed. It's really cool stuff."

"Defender is integrated into the operating system. It's integrated with everything. You don't have to spend time analyzing what you have to do to be sure that the integration is okay between the security tool and all the other apps."

"It is a straightforward setup."

"It provides peace of mind with really good pricing."

"Defender for Endpoint saves me a lot of time because I have all the alerts and information in one application."

"The most valuable aspect lies in its automation capabilities, particularly within security automation."

More Microsoft Defender for Endpoint pros

"They can provide you with very contextual alerts on if something bad is happening—coming into your network or going out of your network."

"They can provide you very contextual alerts on if something bad is happening—coming into your network or going out of your network. As part of that, they gather a lot of threat intelligence and map your connections against that. The larger benefit is that they give you a risk rating on their findings."

Cons

"Cortex does not offer an on-premises solution. However, some customers would prefer not to be on the cloud. It would be ideal if it could offer something on-prem as well."

"One thing that was missing was the integration part. Currently, they don't have out-of-box integration with IBM QRadar, or if they have the integration, the integration doesn't work well."

"When it comes to core analysis, and security analysis, Cortex needs to provide more information."

"Dashboards do not allow everyone to see what's happening."

"I have run into some detection issues with Cortex XDR. It needs to be better at detection of internal attacks."

"The product's pricing could be better."

"The encryption is not up to the mark."

"There's an overall lack of features."

More Cortex XDR by Palo Alto Networks cons

"One thing that was lacking in Defender was web filtering. Its web filtering wasn't as comprehensive."

"Its interface can be improved a little bit. We would like to have some sort of centralization. It should have something like a central server that is managing all the other clients. There are solutions from Kaspersky or ESET NOD32 that are really doing this kind of thing currently. We would like to see something similar from Microsoft."

"Defender could be more secure and stable."

"It makes your Surface devices hot. It is resource-intensive."

"Microsoft Defender for Endpoint can improve by providing more and different types of reports."

"Integrating this with third-party systems has some complexity involved."

"Features like device inventory continue to lack essential workstation drill-downs showing the entire device information with the least effort."

"I think the solution needs to be more on par with other antivirus products in the market."

More Microsoft Defender for Endpoint cons

"My challenge is actually comparing offerings from different vendors across a threat spectrum that is very large."

"My challenge is actually comparing offerings from different vendors across a threat spectrum that is very large. We are talking about millions of threats. How are you confident that Blue Hexagon is catching all one million of them and Palo Alto is doing the same thing? They all have their strengths. Within that, Blue Hexagon might cover 990,000 of them. Palo Alto might cover another 990,000. It's a bit difficult to compare them and say, "Oh, are they catching the same 990,000?" I don't know."

Pricing and Cost Advice

"This is an expensive solution."

"The pricing is a little bit on the expensive side."

"The solution is expensive. It's pricing is on a yearly-basis."

"We didn't have to pay any additional fee for the cloud instance. It just came with the renewal, which was nice."

"The tool's price is moderate."

"Licensing for Palo Alto Networks Cortex XDR can be costly, especially when it comes to a hundred users. A license is required for each user, and the subscription must be renewed on a yearly basis."

"Our customers have expressed that the price is high."

"Cortex XDR by Palo Alto Networks is quite an expensive solution."

More Cortex XDR by Palo Alto Networks pricing and cost advice

"Microsoft Defender for Endpoint is included with a Microsoft E5 license."

"Currently, for us, Windows Defender is free with the purchase of Windows Server. Pricing is an important point for us when we are looking at the competitors of this solution. If we choose to go with another vendor, we will have to pay some license fees."

"We mostly use Microsoft products. We use Office 365, and we use Azure. We're also a Microsoft partner. So, the licensing was much cheaper for us, and at the same time, a lot of the features that we were looking for were included in Defender."

"Microsoft Defender for Endpoint is more affordable compared to some other endpoint solutions."

"The pricing is competitive."

"The cost is high, compared to other products in the market, if you look at it as a separate product. If you look at the cost where it is part of a bundle, the cost is okay."

"The solution comes as part of Microsoft Windows."

"Defender doesn't cost that much. When you use Microsoft technology, you can start with the free version and see how much the technology helps your organization solve security problems before you use the subscription. They also do this pay-as-you-go model, so you only pay when you use it."

More Microsoft Defender for Endpoint pricing and cost advice

"It's difficult to state the setup cost. All the NDRs range anywhere between $500,000, plus or minus, to $2 million. There's a spread of pricing here, depending on who you are talking to. Obviously the major brand names want more money. They typically bundle it with their other offerings. With Cisco, for example, you don't just buy an NDR. So, typically it gets rolled into the cost."

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Top Industries

By visitors reading reviews

Financial Services Firm

12%

Construction Company

12%

Comms Service Provider

Manufacturing Company

Computer Software Company

Financial Services Firm

Manufacturing Company

Government

Financial Services Firm

15%

Comms Service Provider

12%

Construction Company

12%

Government

Company Size

By reviewers

Large Enterprise

Midsize Enterprise

Small Business

By reviewers
Company Size	Count
Small Business	45
Midsize Enterprise	21
Large Enterprise	48

By reviewers
Company Size	Count
Small Business	82
Midsize Enterprise	43
Large Enterprise	95

No data available

Questions from the Community

Cortex XDR by Palo Alto vs. Sentinel One

Cortex XDR by Palo Alto vs. SentinelOne SentinelOne offers very detailed specifics with regard to risks or attacks. ...

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Comparing CrowdStrike Falcon to Cortex XDR (Palo Alto)

Cortex XDR by Palo Alto vs. CrowdStrike Falcon Both Cortex XDR and Crowd Strike Falcon offer cloud-based solutions th...

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How is Cortex XDR compared with Microsoft Defender?

Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface,...

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Which offers better endpoint security - Symantec or Microsoft Defender?

We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior sol...

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How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?

The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never pu...

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What is your experience regarding pricing and costs for Microsoft Defender for Endpoint?

We have been discussing pricing, setup cost, and licensing, and we are currently on an E3. We are discussing going to...

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Comparisons

SentinelOne Singularity Endpoint vs Cortex XDR by Palo Alto Networks

Compared 5% of the time

CrowdStrike Falcon vs Cortex XDR by Palo Alto Networks

Compared 4% of the time

Cortex XSIAM vs Cortex XDR by Palo Alto Networks

Compared 3% of the time

Symantec Endpoint Security vs Cortex XDR by Palo Alto Networks

Compared 3% of the time

Trellix Endpoint Security Platform vs Cortex XDR by Palo Alto Networks

Compared 3% of the time

More Cortex XDR by Palo Alto Networks Competitors

CrowdStrike Falcon vs Microsoft Defender for Endpoint

Compared 4% of the time

OpenText Core Endpoint Protection vs Microsoft Defender for Endpoint

Compared 4% of the time

HP Wolf Security vs Microsoft Defender for Endpoint

Compared 4% of the time

Symantec Endpoint Security vs Microsoft Defender for Endpoint

Compared 3% of the time

F-Secure Total vs Microsoft Defender for Endpoint

Compared 2% of the time

More Microsoft Defender for Endpoint Competitors

CrowdStrike Falcon vs Qualys Multi-Vector EDR

Compared 23% of the time

ExtraHop Reveal(x) vs Qualys Multi-Vector EDR

Compared 11% of the time

Huntress Managed EDR vs Qualys Multi-Vector EDR

Compared 8% of the time

Darktrace vs Qualys Multi-Vector EDR

Compared 7% of the time

Lookout vs Qualys Multi-Vector EDR

Compared 6% of the time

More Qualys Multi-Vector EDR Competitors

Product Reports

Buyer's Guide

Cortex XDR by Palo Alto Networks

May 2026

Download Cortex XDR by Palo Alto Networks product report

Buyer's Guide

Microsoft Defender for Endpoint

April 2026

Download Microsoft Defender for Endpoint product report

Buyer's Guide

Endpoint Detection and Response (EDR)

April 2026

Download Qualys Multi-Vector EDR product report

Also Known As

Cyvera, Cortex XDR, Palo Alto Networks Traps

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus

Blue Hexagon

Interactive Demo

Demo not available

Palo Alto Networks

Microsoft

Demo not available

Qualys

Overview

Cortex XDR by Palo Alto Networks provides advanced threat detection with AI-driven endpoint protection and seamless integration, ensuring multi-layered security and automatic threat response.

Cortex XDR is designed to safeguard endpoints against malware and suspicious activities. It offers advanced threat detection and response capabilities using behavioral analysis, AI, and machine learning. It seamlessly integrates with security infrastructures, providing endpoint security, firewall integration, and enhanced visibility in both cloud-based and on-premises environments.

What are the key features of Cortex XDR?

Advanced Threat Detection: Uses AI and machine learning for proactive threat identification.
Multi-layered Security: Combines various security measures for comprehensive protection.
Endpoint Protection: Safeguards against malware and exploits.
Behavioral Analysis: Monitors suspicious activity for early detection.
Automatic Threat Response: Automates responses to neutralize threats.

What benefits should users expect?

Ease of Use: Simplifies security management with intuitive design.
Resource Efficiency: Minimizes impact on system resources.
Integration Capabilities: Works well with existing security setups.
Reduced Analyst Workload: Automates processes to decrease manual intervention.

Organizations in diverse sectors deploy Cortex XDR to protect against malware, leveraging its advanced threat detection capabilities. Its integration with existing security infrastructures appeals to those seeking comprehensive protection in both cloud and on-premises environments, providing enhanced visibility and threat intelligence.

Palo Alto Networks

Microsoft Defender for Endpoint provides comprehensive threat protection that integrates well with current systems, offering proactive threat detection and automatic updates while reducing manual efforts.

The platform is designed for seamless integration with Microsoft products, facilitating efficient management and use. It offers proactive ransomware protection and valuable threat intelligence, crucial for timely response and increased visibility across devices. Users highlight its ability to secure endpoints from viruses and malware, integrating with Windows and Office 365 to enhance real-time detection capabilities in diverse environments, including hybrid and on-premises setups. However, enhancements are needed in Linux integration, detection accuracy, and policy implementations.

What are the key features of Microsoft Defender for Endpoint?

Seamless Integration: Works smoothly with existing systems and Microsoft products for easy management.
Proactive Threat Detection: Advanced monitoring to identify and mitigate threats swiftly.
Ransomware Protection: Built-in features to protect against ransomware attacks automatically.
Centralized Management: Unified platform for better device visibility and collaboration.
Threat Intelligence: Provides critical data for rapid threat response.

What benefits should be evaluated in Microsoft Defender for Endpoint?

Cost-Effectiveness: Part of Windows bundles, offering comprehensive security at competitive pricing.
Time Efficiency: Reduces manual oversight with automatic updates and management ease.
Real-Time Detection: Enhanced security through seamless Office 365 and Windows integration.
Device Coverage: Supports hybrid and on-premises environments for varied digital infrastructures.

Microsoft Defender for Endpoint is implemented across industries for securing endpoints, relying on its deep integration with Windows and Office 365 to protect against malware and viruses. Organizations benefit from its real-time detection and comprehensive management capabilities, particularly in hybrid environments where diverse digital infrastructures need safeguarding.

Microsoft

Qualys Multi-Vector EDR is designed for real-time threat detection and response, offering comprehensive visibility into potential security breaches across endpoints.

This solution integrates seamlessly with other Qualys modules, facilitating automated workflows that streamline incident management and enhance efficiency in monitoring and mitigating cyber threats. With features like real-time monitoring, detailed reporting, and proactive alerting, security teams can quickly identify and address vulnerabilities. While appreciated for its scalability and ease of deployment, users suggest improvements in integration, reporting, and configuration to further enhance its capabilities.

What are the key features of Qualys Multi-Vector EDR?

Real-time Threat Detection: Continuously monitors endpoints to detect potential threats immediately.
Seamless Integration: Integrates with other Qualys modules and existing systems for streamlined operations.
Automated Response: Automates incident response workflows to enhance efficiency and reduce manual tasks.
Detailed Reporting: Provides in-depth reports to support proactive security measures and quick remediation.
Scalability: Suitable for businesses of varying sizes due to its scalable architecture.

What are the benefits and ROI to look for when evaluating Qualys Multi-Vector EDR?

Enhanced Security: Comprehensive threat detection ensures robust security measures.
Improved Efficiency: Automated workflows save time and reduce manual intervention.
Quick Remediation: Real-time alerts and detailed reports facilitate swift vulnerability mitigation.
Cost-effective Deployment: Scalable and resource-efficient architecture suitable for businesses large and small.

Qualys Multi-Vector EDR is implemented across industries such as finance, healthcare, and retail, where real-time threat detection and automated response are critical. Its ability to integrate with existing systems and provide detailed reporting makes it a valuable asset for enhancing cybersecurity measures in diverse environments.

Qualys

Sample Customers

CBI Health Group, University Honda, VakifBank

Petrofrac, Metro CSG, Christus Health

Pacific Dental Services, Greenhill and Co, Heffernan Insurance Brokers

Buyer's Guide

Endpoint Detection and Response (EDR)

April 2026

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