Microsoft Defender for Endpoint vs Qualys Multi-Vector EDR comparison

Microsoft and Qualys are both solutions in the Endpoint Detection and Response (EDR) category. Microsoft is ranked #3 with an average rating of 8.4, while Qualys is ranked #75. Microsoft holds a 5.9% mindshare in EDR, compared to Qualys’s 0.4% mindshare. Additionally, 95% of Microsoft users are willing to recommend the solution, compared to 100% of Qualys users who would recommend it.

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Executive Summary

We performed a comparison between Microsoft Defender for Endpoint and Qualys Multi-Vector EDR based on real PeerSpot user reviews.

Find out what your peers are saying about CrowdStrike, SentinelOne, Microsoft and others in Endpoint Detection and Response (EDR).

To learn more, read our detailed Endpoint Detection and Response (EDR) Report (Updated: June 2026).

Buyer's Guide

Endpoint Detection and Response (EDR)

June 2026

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Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Categories and Ranking

Cortex XDR by Palo Alto Net...

Mindshare comparison

As of June 2026, in the Endpoint Detection and Response (EDR) category, the mindshare of Cortex XDR by Palo Alto Networks is 3.5%, down from 4.0% compared to the previous year. The mindshare of Microsoft Defender for Endpoint is 5.9%, down from 10.5% compared to the previous year. The mindshare of Qualys Multi-Vector EDR is 0.4%, up from 0.2% compared to the previous year. It is calculated based on PeerSpot user engagement data.

Endpoint Detection and Response (EDR) Mindshare Distribution
Product	Mindshare (%)
Microsoft Defender for Endpoint	5.9%
Cortex XDR by Palo Alto Networks	3.5%
Qualys Multi-Vector EDR	0.4%
Other	90.2%

Endpoint Detection and Response (EDR)

Featured Reviews

ABHISHEK_SINGH

Senior Process Expert at A.P. Moller - Maersk

Gained full visibility and streamlined threat detection through behavior-based insights and AI integration

Initially, we got to have a lot of false positives when we onboarded, but nowadays it's quite smooth. We have fine-tuned our security policies and allowed different levels of policies to get rid of those false positives. Currently, we are getting a fairly good amount of incidents that are not false positives or benign, but actionable items. The process is streamlined. In the initial days, the operations used to get involved in a lot of benign and other activities, but now the process is streamlined. We are leveraging the auto-detection and remediation plans. The operations teams are now more involved in other business roles as well, not just looking into the logs and fetching out what's happening there. They have fixed a lot of things. Initially, they didn't have IAC code drift detection, cloud posture management, or security posture management, but they have those now. They purchased different vendors and did a merger with that. They have now Prisma Cloud that gets integrated and now they are working with Cortex Cloud. Everything that was negative has now been addressed, and the product altogether looks to be in a very better and mature shape now. Currently, it's more or less detecting the workloads with AI-based best practices. Since most organizations are consuming AI agents and other things, we are looking forward to seeing what other feature enhancements Palo Alto can support in that.

Read full review

Robert Arbuckle

Security Analyst III at a healthcare company with 10,001+ employees

Automatically isolates threats and integrates with logging to reduce response time

Overall, I would evaluate the Microsoft support level that I receive at probably about a seven, but that depends on the day. It has been spotty. We have had issues where the urgency level of the Microsoft support is not as high as ours, especially during a data breach or potential data breach situation. We have had issues with some of the offshore support being lackluster. One specific thing that comes to mind is we were on a support call with our CISO on the call, and the Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, "Just to set expectations, my lunch break is in an hour and I am going to go away then." For us, it was already ten o'clock at night and we had been working on this for a couple of hours, trying to get a security engineer on with us. For him to tell us that he was going to go away and have lunch, it was, "Okay, but go find somebody else if you need to." It was just the lackluster approach, and it seemed like he did not really care. We seem to get a lot of this when we get non-Microsoft support. I can identify areas for improvement with Microsoft Defender for Endpoint, as it is kind of a convoluted mess to try to take care of false positives. Especially when they have been identified as false positives but they keep going off over and over again. It is great for my pocketbook because it generates a lot of on-call action, but I would really prefer more sleep at two o'clock in the morning than dealing with false positives. I would say that the unified portal for managing Microsoft Defender for Endpoint is suitable for both teams as they are all in there. It would be great if they would stop moving things around and renaming things, which makes sense. The new XDR portal is pretty nice. Being able to have it central again inside of the regular Security Center without having to open up two windows is helpful. Overall, I think it is pretty good. There is always going to be something that could be improved, such as alerting and the ability to modify alerts would be a little bit helpful to have. Being able to add more data into the alerts and turn off alerts that are not as useful would be beneficial. It is hard to say what the quantitative impact the security exposure management feature has had on our company's security, because a lot of it is kind of subjective. I think we are sitting at around a fifty percent score still, and a lot of it is just kind of unusual circumstances that we cannot really implement without breaking the organization.

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reviewer1668453

Director, Security Innovation at a insurance company with 10,001+ employees

Provides contextual alerts and risk ratings on findings

It's kind of difficult to quantify areas for improvement. In the larger picture, one challenge is that the NDR space is very crowded today. I can mention half a dozen names just off the top of my head. There are at least 12 to 20 different players. All of them are well-known brand names, and it's difficult to compare them. They all claim to be giving you the same network difference capability: catching malware, dealing with all the minor taxonomy of attack, all that. Still, it's very difficult to compare them side by side because they all do things a little differently, and they all have different presentations and output. We haven't deployed it, so I can't give you what we felt about it exactly. But in the larger perspective, the critical feature is really giving a clear separation between a low, high, and medium criticality. You need a rating that is really true to the actual attack. There's one other capability we are evaluating them for, and it's for custom alerts detection. A lot of these products are trying to profile the threats that are already out there in the industry. They're very well known and published. Today, there are targeted acts being played against organizations, so you have to be sensitive to how your firewalls, protocols, and your HTTP are all operating. You might have some fine-tuned threats that are targeting you, and you should be able to build custom defenses. They should have some openness in terms of how you specify your threats. You get a standard library of threats. On top of it, every organization builds its own.

Read full review

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Pros

"They have a new GUI which is just fantastic."

"Monitoring is most valuable."

"The information the dashboard provides is very clear."

"The solution allows us to make investigations. Other XDR solutions also provide similar capabilities but for investigation, Cortex XDR is better."

"The protection offered by this product is good, as is the endpoint reporting."

"One of the main benefits of the solution is its intelligence to correlate the events into an incident."

"The good thing about the product is that it's always scanning."

"We switched because there were a lot of added features with Palo Alto that Check Point didn't have, and it was an upgrade for us."

More Cortex XDR by Palo Alto Networks pros

"The attack surface reduction rules are the most valuable. We're able to have unattended remediation actions when the solution works side by side with a local antivirus like Microsoft Defender or Kaspersky. The attack surface reduction rules help us to proactively block and stop threats."

"What the Defender platform does is that it reduces the size of the haystack, and it'll say that the needle is over here."

"Defender should be fine for home use. It has all the basic functionality you need. I can't speak to how well it works as an enterprise solution because I'm not in the space."

"The features of Microsoft Defender for Endpoint that I like the most are that it is not a very intrusive product, so it is not using up a lot of compute."

"Microsoft Defender for Endpoint is useful for the protection of your business information and threat prevention."

"We have not had any attacks, in terms of viruses, worms, or ransomware, in the last three years."

"With its intelligence and tools over cloud infrastructure, it's a good product."

"It is already integrated with Windows 10, so you don't need to worry about that."

More Microsoft Defender for Endpoint pros

"They can provide you very contextual alerts on if something bad is happening—coming into your network or going out of your network. As part of that, they gather a lot of threat intelligence and map your connections against that. The larger benefit is that they give you a risk rating on their findings."

Cons

"The price could be a little lower."

"I would like to see them include NDR (Network Detection Response). Then it would work well with SIEM Response."

"It's very time-consuming to log support issues and the people that answer the tickets aren't very knowledgeable."

"I recommend adding a data loss prevention (DLP) solution to Cortex XDR by Palo Alto Networks. The inclusion of this feature would allow the application of DLP policies alongside antivirus policies via a single agent and console, making it more competitive as other OEMs often offer DLP solutions as part of their antivirus products."

"There are some default policies which sometimes affect our applications and cause them to run around. In the hotel industry, we use a different type of data versus Oracle and SQL. By default, there are some policies which stop us from running properly. Because of this, the support level is also not that strong. We have to wait to get a results."

"The solution can never really be an on-premises solution based simply on the way it is set up. It needs metadata to run and improve. Having an on-premises solution would cut it off from making improvements."

"The installation should be easier and the Palo Alto pre-sales and sales teams should have more information on the product because they don't know what they are selling."

"This product has not improved my organization - in fact, we are in the process of moving back to another product as a result of Cortex's horrible impact on system performance."

More Cortex XDR by Palo Alto Networks cons

"We encountered some misbehavior between Microsoft Office Suite and Defender. We had issues of old macros being blocked and some stuff going around the usage of Win32 APIs. There is some improvement between the Office products and Defender, and there is a bunch of stuff that you can configure in your antivirus solutions, but you have several baselines, such as security baselines for Edge, security baselines for Defender, and security baselines for MDM. You have configuration profiles as well. So, there a lot of parts where we can configure our antivirus solution, and we're getting conflicting configurations. This is the major part with which we're struggling in this solution. We are having calls and calls with Microsoft for getting rid of all configuration conflicts that we have. That's really the part that needs to be improved."

"The scanning is slow when it is working with incoming emails."

"There is no behavior analytics for devices and endpoints. There is no behavior-based protection."

"This solution needs to move beyond relying on virus definitions alone and protect the system using behavioral analysis of the processes that are running."

"The time it takes to implement policies has room for improvement."

"Its user interface (UI) can be improved. Currently, in the console, you have to dig down for certain things. They've got many different layers to get to things instead of having it all on the surface. You have to go three folds lower to get to specific functionality or click a particular option. It would be good if we can manage the console through menus and instead of three clicks, we can do things in one click. They need to change the UI and work on it in terms of a better user experience."

"The user interface could use some improvement."

"There are alternative solutions that offer a greater range of dashboard insights when compared to Microsoft Defender for Endpoint."

More Microsoft Defender for Endpoint cons

"My challenge is actually comparing offerings from different vendors across a threat spectrum that is very large. We are talking about millions of threats. How are you confident that Blue Hexagon is catching all one million of them and Palo Alto is doing the same thing? They all have their strengths. Within that, Blue Hexagon might cover 990,000 of them. Palo Alto might cover another 990,000. It's a bit difficult to compare them and say, "Oh, are they catching the same 990,000?" I don't know."

"My challenge is actually comparing offerings from different vendors across a threat spectrum that is very large."

Pricing and Cost Advice

"Our customers have expressed that the price is high."

"I feel it is fairly priced."

"Our license will require renewal in August, after which the maintenance will continue as usual."

"It is "expensive" and flexible."

"The price of the solution could be reduced. I have customers that have voiced that the solution is good for the value but if I want to sell more of the solution the price reduction would help."

"The cost depends on your chosen license type, like Pro or other licenses."

"It's way too expensive, but security is expensive. You pay for your licensing, and then you pay for someone to monitor the stuff."

"The pricing seems fair, and I do like the licensing model. You use wherever they are, and it is elastic."

More Cortex XDR by Palo Alto Networks pricing and cost advice

"You need a license to use this solution."

"Licensing options vary. Some customers buy it as an enterprise agreement and pay yearly. Others buy it as a CSP, so they pay per month. It completely depends on the customer's needs."

"The product is free of charge and comes integrated into Windows."

"It is free."

"Microsoft Defender for Endpoint is cost-effective because there's one unified license, and with this unified license, you get the capabilities for your cloud applications, servers, and endpoints as well. Therefore, it saves us a lot of money because the cost with other solutions is for just one piece of OS or maybe an urban environment. The licensing process is not complex as well."

"Because Microsoft Defender comes as an add-on, it can be a bit expensive if you're trying to buying it separately. Another option is to upgrade, but the enterprise licenses for Microsoft can also be quite a bit pricey. Overall, the cost of Microsoft Defender compared to that of other endpoint detection solutions is slightly higher."

"It is built into Windows 10. If our clients are using Microsoft Defender, the cost goes away for them."

"Pricing can always be lower."

More Microsoft Defender for Endpoint pricing and cost advice

"It's difficult to state the setup cost. All the NDRs range anywhere between $500,000, plus or minus, to $2 million. There's a spread of pricing here, depending on who you are talking to. Obviously the major brand names want more money. They typically bundle it with their other offerings. With Cisco, for example, you don't just buy an NDR. So, typically it gets rolled into the cost."

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Top Industries

By visitors reading reviews

Construction Company

12%

Financial Services Firm

11%

Manufacturing Company

10%

Comms Service Provider

Manufacturing Company

10%

Financial Services Firm

10%

Computer Software Company

Comms Service Provider

Financial Services Firm

15%

Comms Service Provider

12%

Construction Company

12%

Government

Company Size

By reviewers

Large Enterprise

Midsize Enterprise

Small Business

By reviewers
Company Size	Count
Small Business	46
Midsize Enterprise	20
Large Enterprise	52

By reviewers
Company Size	Count
Small Business	82
Midsize Enterprise	45
Large Enterprise	96

No data available

Questions from the Community

Cortex XDR by Palo Alto vs. Sentinel One

Cortex XDR by Palo Alto vs. SentinelOne SentinelOne offers very detailed specifics with regard to risks or attacks. ...

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Comparing CrowdStrike Falcon to Cortex XDR (Palo Alto)

Cortex XDR by Palo Alto vs. CrowdStrike Falcon Both Cortex XDR and Crowd Strike Falcon offer cloud-based solutions th...

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How is Cortex XDR compared with Microsoft Defender?

Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface,...

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Which offers better endpoint security - Symantec or Microsoft Defender?

We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior sol...

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How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?

The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never pu...

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What is your experience regarding pricing and costs for Microsoft Defender for Endpoint?

We have been discussing pricing, setup cost, and licensing, and we are currently on an E3. We are discussing going to...

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Comparisons

SentinelOne Singularity Endpoint vs Cortex XDR by Palo Alto Networks

Compared 5% of the time

CrowdStrike Falcon vs Cortex XDR by Palo Alto Networks

Compared 4% of the time

Cortex XSIAM vs Cortex XDR by Palo Alto Networks

Compared 3% of the time

Symantec Endpoint Security vs Cortex XDR by Palo Alto Networks

Compared 3% of the time

Trellix Endpoint Security Platform vs Cortex XDR by Palo Alto Networks

Compared 3% of the time

More Cortex XDR by Palo Alto Networks Competitors

OpenText Core Endpoint Protection vs Microsoft Defender for Endpoint

Compared 4% of the time

CrowdStrike Falcon vs Microsoft Defender for Endpoint

Compared 4% of the time

HP Wolf Security vs Microsoft Defender for Endpoint

Compared 3% of the time

Symantec Endpoint Security vs Microsoft Defender for Endpoint

Compared 3% of the time

SentinelOne Singularity Endpoint vs Microsoft Defender for Endpoint

Compared 2% of the time

More Microsoft Defender for Endpoint Competitors

CrowdStrike Falcon vs Qualys Multi-Vector EDR

Compared 22% of the time

ExtraHop Reveal(x) vs Qualys Multi-Vector EDR

Compared 11% of the time

Darktrace vs Qualys Multi-Vector EDR

Compared 8% of the time

Huntress Managed EDR vs Qualys Multi-Vector EDR

Compared 7% of the time

Lookout vs Qualys Multi-Vector EDR

Compared 6% of the time

More Qualys Multi-Vector EDR Competitors

Product Reports

Buyer's Guide

Cortex XDR by Palo Alto Networks

June 2026

Download Cortex XDR by Palo Alto Networks product report

Buyer's Guide

Microsoft Defender for Endpoint

June 2026

Download Microsoft Defender for Endpoint product report

Buyer's Guide

Endpoint Detection and Response (EDR)

June 2026

Download Qualys Multi-Vector EDR product report

Also Known As

Cyvera, Cortex XDR, Palo Alto Networks Traps

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus

Blue Hexagon

Interactive Demo

Demo not available

Palo Alto Networks

Microsoft

Demo not available

Qualys

Overview

Cortex XDR by Palo Alto Networks provides advanced threat detection with AI-driven endpoint protection and seamless integration, ensuring multi-layered security and automatic threat response.

Cortex XDR is designed to safeguard endpoints against malware and suspicious activities. It offers advanced threat detection and response capabilities using behavioral analysis, AI, and machine learning. It seamlessly integrates with security infrastructures, providing endpoint security, firewall integration, and enhanced visibility in both cloud-based and on-premises environments.

What are the key features of Cortex XDR?

Advanced Threat Detection: Uses AI and machine learning for proactive threat identification.
Multi-layered Security: Combines various security measures for comprehensive protection.
Endpoint Protection: Safeguards against malware and exploits.
Behavioral Analysis: Monitors suspicious activity for early detection.
Automatic Threat Response: Automates responses to neutralize threats.

What benefits should users expect?

Ease of Use: Simplifies security management with intuitive design.
Resource Efficiency: Minimizes impact on system resources.
Integration Capabilities: Works well with existing security setups.
Reduced Analyst Workload: Automates processes to decrease manual intervention.

Organizations in diverse sectors deploy Cortex XDR to protect against malware, leveraging its advanced threat detection capabilities. Its integration with existing security infrastructures appeals to those seeking comprehensive protection in both cloud and on-premises environments, providing enhanced visibility and threat intelligence.

Palo Alto Networks

Microsoft Defender for Endpoint provides comprehensive threat protection that integrates well with current systems, offering proactive threat detection and automatic updates while reducing manual efforts.

The platform is designed for seamless integration with Microsoft products, facilitating efficient management and use. It offers proactive ransomware protection and valuable threat intelligence, crucial for timely response and increased visibility across devices. Users highlight its ability to secure endpoints from viruses and malware, integrating with Windows and Office 365 to enhance real-time detection capabilities in diverse environments, including hybrid and on-premises setups. However, enhancements are needed in Linux integration, detection accuracy, and policy implementations.

What are the key features of Microsoft Defender for Endpoint?

Seamless Integration: Works smoothly with existing systems and Microsoft products for easy management.
Proactive Threat Detection: Advanced monitoring to identify and mitigate threats swiftly.
Ransomware Protection: Built-in features to protect against ransomware attacks automatically.
Centralized Management: Unified platform for better device visibility and collaboration.
Threat Intelligence: Provides critical data for rapid threat response.

What benefits should be evaluated in Microsoft Defender for Endpoint?

Cost-Effectiveness: Part of Windows bundles, offering comprehensive security at competitive pricing.
Time Efficiency: Reduces manual oversight with automatic updates and management ease.
Real-Time Detection: Enhanced security through seamless Office 365 and Windows integration.
Device Coverage: Supports hybrid and on-premises environments for varied digital infrastructures.

Microsoft Defender for Endpoint is implemented across industries for securing endpoints, relying on its deep integration with Windows and Office 365 to protect against malware and viruses. Organizations benefit from its real-time detection and comprehensive management capabilities, particularly in hybrid environments where diverse digital infrastructures need safeguarding.

Microsoft

Qualys Multi-Vector EDR is designed for real-time threat detection and response, offering comprehensive visibility into potential security breaches across endpoints.

This solution integrates seamlessly with other Qualys modules, facilitating automated workflows that streamline incident management and enhance efficiency in monitoring and mitigating cyber threats. With features like real-time monitoring, detailed reporting, and proactive alerting, security teams can quickly identify and address vulnerabilities. While appreciated for its scalability and ease of deployment, users suggest improvements in integration, reporting, and configuration to further enhance its capabilities.

What are the key features of Qualys Multi-Vector EDR?

Real-time Threat Detection: Continuously monitors endpoints to detect potential threats immediately.
Seamless Integration: Integrates with other Qualys modules and existing systems for streamlined operations.
Automated Response: Automates incident response workflows to enhance efficiency and reduce manual tasks.
Detailed Reporting: Provides in-depth reports to support proactive security measures and quick remediation.
Scalability: Suitable for businesses of varying sizes due to its scalable architecture.

What are the benefits and ROI to look for when evaluating Qualys Multi-Vector EDR?

Enhanced Security: Comprehensive threat detection ensures robust security measures.
Improved Efficiency: Automated workflows save time and reduce manual intervention.
Quick Remediation: Real-time alerts and detailed reports facilitate swift vulnerability mitigation.
Cost-effective Deployment: Scalable and resource-efficient architecture suitable for businesses large and small.

Qualys Multi-Vector EDR is implemented across industries such as finance, healthcare, and retail, where real-time threat detection and automated response are critical. Its ability to integrate with existing systems and provide detailed reporting makes it a valuable asset for enhancing cybersecurity measures in diverse environments.

Qualys

Sample Customers

CBI Health Group, University Honda, VakifBank

Petrofrac, Metro CSG, Christus Health

Pacific Dental Services, Greenhill and Co, Heffernan Insurance Brokers

Buyer's Guide

Endpoint Detection and Response (EDR)

June 2026

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