Microsoft Defender for Endpoint vs Qualys Multi-Vector EDR comparison

Why PeerSpot?

Microsoft and Qualys are both solutions in the Endpoint Detection and Response (EDR) category. Microsoft is ranked #3 with an average rating of 8.4, while Qualys is ranked #77. Microsoft holds a 5.5% mindshare in EDR, compared to Qualys’s 0.4% mindshare. Additionally, 95% of Microsoft users are willing to recommend the solution, compared to 100% of Qualys users who would recommend it.

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Executive Summary

We performed a comparison between Microsoft Defender for Endpoint and Qualys Multi-Vector EDR based on real PeerSpot user reviews.

Find out what your peers are saying about SentinelOne, CrowdStrike, Microsoft and others in Endpoint Detection and Response (EDR).

To learn more, read our detailed Endpoint Detection and Response (EDR) Report (Updated: September 2026).

Buyer's Guide

Endpoint Detection and Response (EDR)

September 2026

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Helped 913,806 peers since 2012

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Categories and Ranking

Cortex XDR by Palo Alto Net...

Mindshare comparison

As of September 2026, in the Endpoint Detection and Response (EDR) category, the mindshare of Cortex XDR by Palo Alto Networks is 3.6%, down from 3.9% compared to the previous year. The mindshare of Microsoft Defender for Endpoint is 5.5%, down from 9.9% compared to the previous year. The mindshare of Qualys Multi-Vector EDR is 0.4%, up from 0.2% compared to the previous year. It is calculated based on PeerSpot user engagement data.

Endpoint Detection and Response (EDR) Mindshare Distribution
Product	Mindshare (%)
Microsoft Defender for Endpoint	5.5%
Cortex XDR by Palo Alto Networks	3.6%
Qualys Multi-Vector EDR	0.4%
Other	90.5%

Endpoint Detection and Response (EDR)

Featured Reviews

ABHISHEK_SINGH

Senior Process Expert at A.P. Moller - Maersk

Gained full visibility and streamlined threat detection through behavior-based insights and AI integration

Initially, we got to have a lot of false positives when we onboarded, but nowadays it's quite smooth. We have fine-tuned our security policies and allowed different levels of policies to get rid of those false positives. Currently, we are getting a fairly good amount of incidents that are not false positives or benign, but actionable items. The process is streamlined. In the initial days, the operations used to get involved in a lot of benign and other activities, but now the process is streamlined. We are leveraging the auto-detection and remediation plans. The operations teams are now more involved in other business roles as well, not just looking into the logs and fetching out what's happening there. They have fixed a lot of things. Initially, they didn't have IAC code drift detection, cloud posture management, or security posture management, but they have those now. They purchased different vendors and did a merger with that. They have now Prisma Cloud that gets integrated and now they are working with Cortex Cloud. Everything that was negative has now been addressed, and the product altogether looks to be in a very better and mature shape now. Currently, it's more or less detecting the workloads with AI-based best practices. Since most organizations are consuming AI agents and other things, we are looking forward to seeing what other feature enhancements Palo Alto can support in that.

Read full review

Robert Arbuckle

Security Analyst III at a healthcare company with 10,001+ employees

Automatically isolates threats and integrates with logging to reduce response time

Overall, I would evaluate the Microsoft support level that I receive at probably about a seven, but that depends on the day. It has been spotty. We have had issues where the urgency level of the Microsoft support is not as high as ours, especially during a data breach or potential data breach situation. We have had issues with some of the offshore support being lackluster. One specific thing that comes to mind is we were on a support call with our CISO on the call, and the Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, "Just to set expectations, my lunch break is in an hour and I am going to go away then." For us, it was already ten o'clock at night and we had been working on this for a couple of hours, trying to get a security engineer on with us. For him to tell us that he was going to go away and have lunch, it was, "Okay, but go find somebody else if you need to." It was just the lackluster approach, and it seemed like he did not really care. We seem to get a lot of this when we get non-Microsoft support. I can identify areas for improvement with Microsoft Defender for Endpoint, as it is kind of a convoluted mess to try to take care of false positives. Especially when they have been identified as false positives but they keep going off over and over again. It is great for my pocketbook because it generates a lot of on-call action, but I would really prefer more sleep at two o'clock in the morning than dealing with false positives. I would say that the unified portal for managing Microsoft Defender for Endpoint is suitable for both teams as they are all in there. It would be great if they would stop moving things around and renaming things, which makes sense. The new XDR portal is pretty nice. Being able to have it central again inside of the regular Security Center without having to open up two windows is helpful. Overall, I think it is pretty good. There is always going to be something that could be improved, such as alerting and the ability to modify alerts would be a little bit helpful to have. Being able to add more data into the alerts and turn off alerts that are not as useful would be beneficial. It is hard to say what the quantitative impact the security exposure management feature has had on our company's security, because a lot of it is kind of subjective. I think we are sitting at around a fifty percent score still, and a lot of it is just kind of unusual circumstances that we cannot really implement without breaking the organization.

Read full review

reviewer1668453

Director, Security Innovation at a insurance company with 10,001+ employees

Provides contextual alerts and risk ratings on findings

It's kind of difficult to quantify areas for improvement. In the larger picture, one challenge is that the NDR space is very crowded today. I can mention half a dozen names just off the top of my head. There are at least 12 to 20 different players. All of them are well-known brand names, and it's difficult to compare them. They all claim to be giving you the same network difference capability: catching malware, dealing with all the minor taxonomy of attack, all that. Still, it's very difficult to compare them side by side because they all do things a little differently, and they all have different presentations and output. We haven't deployed it, so I can't give you what we felt about it exactly. But in the larger perspective, the critical feature is really giving a clear separation between a low, high, and medium criticality. You need a rating that is really true to the actual attack. There's one other capability we are evaluating them for, and it's for custom alerts detection. A lot of these products are trying to profile the threats that are already out there in the industry. They're very well known and published. Today, there are targeted acts being played against organizations, so you have to be sensitive to how your firewalls, protocols, and your HTTP are all operating. You might have some fine-tuned threats that are targeting you, and you should be able to build custom defenses. They should have some openness in terms of how you specify your threats. You get a standard library of threats. On top of it, every organization builds its own.

Read full review

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Pros

"If the user leaves our premises or network, Palo Alto Traps will still be on that endpoint and will still apply our policies."

"The one feature of Palo Alto Networks Traps that our organization finds most valuable is the App ID service."

"It is a simple platform to use."

"I like that the product has behavior-based detection which offers many benefits over signature-based detection."

"They have a new GUI which is just fantastic."

"Monitoring is most valuable."

"My advice for anybody who is considering Cortex XDR is that it is a complete solution, and has very good features."

"Since using Cortex XDR by Palo Alto Networks, our MTTR has reduced, which means the mean time to resolve any ticket has been reduced."

More Cortex XDR by Palo Alto Networks pros

"It's a very solid security system, and the advanced hunting and everything really lets you dive deep into things."

"The patch management is very easy, as it can be done automatically or added to a schedule."

"This software is easy to use."

"In Windows 11, Defender is very, very strong."

"The most valuable feature of Microsoft Defender for Endpoint is that it is embedded into the Windows system. Additionally, the performance is good and simple to maintain."

"It's a stable solution."

"The virus scanning capability is excellent, and it feeds all the logs into the Microsoft 365 Defender portal, making them easy to search for."

"Easy to understand and easy to set up endpoint security solution. It's a multifeatured product with web content filtering and automated investigation features. It also has a fantastic vulnerability management dashboard."

More Microsoft Defender for Endpoint pros

"They can provide you very contextual alerts on if something bad is happening—coming into your network or going out of your network. As part of that, they gather a lot of threat intelligence and map your connections against that. The larger benefit is that they give you a risk rating on their findings."

Cons

"Whenever the tool releases a new version when deploying the product across the organization, I feel like there are some disturbances in the CPU usage after upgrading the tool to the latest version."

"The solution could improve by providing better integration with their own products and others."

"There's an overall lack of features."

"I have faced some issues with Cortex XDR by Palo Alto Networks; there is room for improvement in the sense that certain options prevent us from seeing and segregating data."

"The GUI could be improved. It's a little bit cumbersome. It could be more user-friendly."

"To jump from the partner to Palo Alto directly was challenging."

"Although I would say this product is highly-rated, it could probably do more because nothing does everything that you want."

"Enhancing UI simplicity and playbook flexibility are areas that could benefit from more low-code automation options for smoother integrations."

More Cortex XDR by Palo Alto Networks cons

"I'm not too sure of its current capabilities, but I'm pretty sure they are doing a good job on Windows and Mac. However, I'm not sure whether they covered Linux. If I remember correctly, Microsoft Defender didn't have anything proper on Linux back then, but if they have improved it from that aspect, it would already be ticking all the boxes."

"Microsoft Defender for Endpoint should have more transparency. In the latest edition of Windows, Windows 11, it is a compulsory requirement to connect to a Microsoft account, which in turn has implications for Defender. This should be removed."

"I think the solution needs to be more on par with other antivirus products in the market."

"Lowering the price would be an improvement."

"Microsoft support could be more knowledgeable."

"It's a good product but it is limited in some cases."

"Cortex... has good investigation capabilities, out-of-the-box, in case there is an event that you'd like to investigate. It's quite convenient. Microsoft has those capabilities as well, but you need a bit more training on the product to get the basic information that you can get out-of-the-box with Cortex."

"Sometimes it is a little lacking, but for the most part, they are able to provide exactly what I need."

More Microsoft Defender for Endpoint cons

"My challenge is actually comparing offerings from different vendors across a threat spectrum that is very large."

"My challenge is actually comparing offerings from different vendors across a threat spectrum that is very large. We are talking about millions of threats. How are you confident that Blue Hexagon is catching all one million of them and Palo Alto is doing the same thing? They all have their strengths. Within that, Blue Hexagon might cover 990,000 of them. Palo Alto might cover another 990,000. It's a bit difficult to compare them and say, "Oh, are they catching the same 990,000?" I don't know."

Pricing and Cost Advice

"If one wishes to work with another team or large number of users at a future point, he must purchase a license for them."

"We didn't have to pay any additional fee for the cloud instance. It just came with the renewal, which was nice."

"It has a higher cost than other solutions, like CrowdStrike or Microsoft’s EDR tools, but it reduces the cost of our operations because it’s a new generation antivirus tool."

"When we first bought it, it was a bit expensive, but it was worth it. The licensing was straightforward."

"Every customer has to pay for a license because it doesn't work with what you get from a managed services provider."

"Cortex XDR by Palo Alto Networks is an expensive solution."

"It is present, but when compared to other competitive products, I would say it is not less expensive; however, when all of the other added values are considered, the price is reasonable."

"Cortex XDR’s pricing is very reasonable."

More Cortex XDR by Palo Alto Networks pricing and cost advice

"The license for Microsoft Windows covers Microsoft Defender for Endpoint."

"You need a license to use this solution."

"The cost is high, compared to other products in the market, if you look at it as a separate product. If you look at the cost where it is part of a bundle, the cost is okay."

"The nice thing about Defender and Sentinel is that the cost is based on the data logs that you ingest from the Defender endpoints and data connectors. I don't have to buy a 25- or 50- or 1,000-user or enterprise license. I can buy one license at a time."

"There is not a license required for this particular solution."

"Pricing can always be lower."

"There is no license needed, the solution comes with Microsoft Windows."

"The solution is free with Windows."

More Microsoft Defender for Endpoint pricing and cost advice

"It's difficult to state the setup cost. All the NDRs range anywhere between $500,000, plus or minus, to $2 million. There's a spread of pricing here, depending on who you are talking to. Obviously the major brand names want more money. They typically bundle it with their other offerings. With Cisco, for example, you don't just buy an NDR. So, typically it gets rolled into the cost."

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Top Industries

By visitors reading reviews

Outsourcing Company

12%

Comms Service Provider

12%

Construction Company

11%

Financial Services Firm

Manufacturing Company

10%

Financial Services Firm

Comms Service Provider

Computer Software Company

Construction Company

16%

Financial Services Firm

14%

Outsourcing Company

11%

Comms Service Provider

Company Size

By reviewers

Large Enterprise

Midsize Enterprise

Small Business

By reviewers
Company Size	Count
Small Business	47
Midsize Enterprise	21
Large Enterprise	55

By reviewers
Company Size	Count
Small Business	82
Midsize Enterprise	44
Large Enterprise	97

No data available

Questions from the Community

Cortex XDR by Palo Alto vs. Sentinel One

Cortex XDR by Palo Alto vs. SentinelOne SentinelOne offers very detailed specifics with regard to risks or attacks. ...

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Comparing CrowdStrike Falcon to Cortex XDR (Palo Alto)

Cortex XDR by Palo Alto vs. CrowdStrike Falcon Both Cortex XDR and Crowd Strike Falcon offer cloud-based solutions th...

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How is Cortex XDR compared with Microsoft Defender?

Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface,...

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Which offers better endpoint security - Symantec or Microsoft Defender?

We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior sol...

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How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?

The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never pu...

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What is your experience regarding pricing and costs for Microsoft Defender for Endpoint?

We have been discussing pricing, setup cost, and licensing, and we are currently on an E3. We are discussing going to...

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Comparisons

SentinelOne Singularity Endpoint vs Cortex XDR by Palo Alto Networks

Compared 5% of the time

CrowdStrike Falcon vs Cortex XDR by Palo Alto Networks

Compared 4% of the time

Cortex XSIAM vs Cortex XDR by Palo Alto Networks

Compared 3% of the time

Symantec Endpoint Security vs Cortex XDR by Palo Alto Networks

Compared 3% of the time

Trellix Endpoint Security Platform vs Cortex XDR by Palo Alto Networks

Compared 3% of the time

More Cortex XDR by Palo Alto Networks Competitors

OpenText Core Endpoint Protection vs Microsoft Defender for Endpoint

Compared 6% of the time

CrowdStrike Falcon vs Microsoft Defender for Endpoint

Compared 3% of the time

Symantec Endpoint Security vs Microsoft Defender for Endpoint

Compared 3% of the time

HP Wolf Security vs Microsoft Defender for Endpoint

Compared 3% of the time

SentinelOne Singularity Endpoint vs Microsoft Defender for Endpoint

Compared 2% of the time

More Microsoft Defender for Endpoint Competitors

CrowdStrike Falcon vs Qualys Multi-Vector EDR

Compared 18% of the time

ExtraHop Reveal(x) vs Qualys Multi-Vector EDR

Compared 10% of the time

Darktrace vs Qualys Multi-Vector EDR

Compared 7% of the time

Huntress Managed EDR vs Qualys Multi-Vector EDR

Compared 6% of the time

TrendAI Vision One vs Qualys Multi-Vector EDR

Compared 5% of the time

More Qualys Multi-Vector EDR Competitors

Product Reports

Buyer's Guide

Cortex XDR by Palo Alto Networks

September 2026

Download Cortex XDR by Palo Alto Networks product report

Buyer's Guide

Microsoft Defender for Endpoint

September 2026

Download Microsoft Defender for Endpoint product report

Buyer's Guide

Endpoint Detection and Response (EDR)

September 2026

Download Qualys Multi-Vector EDR product report

Also Known As

Cyvera, Cortex XDR, Palo Alto Networks Traps

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus

Blue Hexagon

Interactive Demo

Demo not available

Palo Alto Networks

Microsoft

Demo not available

Qualys

Overview

Cortex XDR by Palo Alto Networks provides advanced threat detection with AI-driven endpoint protection and seamless integration, ensuring multi-layered security and automatic threat response.

Cortex XDR is designed to safeguard endpoints against malware and suspicious activities. It offers advanced threat detection and response capabilities using behavioral analysis, AI, and machine learning. It seamlessly integrates with security infrastructures, providing endpoint security, firewall integration, and enhanced visibility in both cloud-based and on-premises environments.

What are the key features of Cortex XDR?

Advanced Threat Detection: Uses AI and machine learning for proactive threat identification.
Multi-layered Security: Combines various security measures for comprehensive protection.
Endpoint Protection: Safeguards against malware and exploits.
Behavioral Analysis: Monitors suspicious activity for early detection.
Automatic Threat Response: Automates responses to neutralize threats.

What benefits should users expect?

Ease of Use: Simplifies security management with intuitive design.
Resource Efficiency: Minimizes impact on system resources.
Integration Capabilities: Works well with existing security setups.
Reduced Analyst Workload: Automates processes to decrease manual intervention.

Organizations in diverse sectors deploy Cortex XDR to protect against malware, leveraging its advanced threat detection capabilities. Its integration with existing security infrastructures appeals to those seeking comprehensive protection in both cloud and on-premises environments, providing enhanced visibility and threat intelligence.

Palo Alto Networks

Microsoft Defender for Endpoint provides comprehensive threat protection that integrates well with current systems, offering proactive threat detection and automatic updates while reducing manual efforts.

The platform is designed for seamless integration with Microsoft products, facilitating efficient management and use. It offers proactive ransomware protection and valuable threat intelligence, crucial for timely response and increased visibility across devices. Users highlight its ability to secure endpoints from viruses and malware, integrating with Windows and Office 365 to enhance real-time detection capabilities in diverse environments, including hybrid and on-premises setups. However, enhancements are needed in Linux integration, detection accuracy, and policy implementations.

What are the key features of Microsoft Defender for Endpoint?

Seamless Integration: Works smoothly with existing systems and Microsoft products for easy management.
Proactive Threat Detection: Advanced monitoring to identify and mitigate threats swiftly.
Ransomware Protection: Built-in features to protect against ransomware attacks automatically.
Centralized Management: Unified platform for better device visibility and collaboration.
Threat Intelligence: Provides critical data for rapid threat response.

What benefits should be evaluated in Microsoft Defender for Endpoint?

Cost-Effectiveness: Part of Windows bundles, offering comprehensive security at competitive pricing.
Time Efficiency: Reduces manual oversight with automatic updates and management ease.
Real-Time Detection: Enhanced security through seamless Office 365 and Windows integration.
Device Coverage: Supports hybrid and on-premises environments for varied digital infrastructures.

Microsoft Defender for Endpoint is implemented across industries for securing endpoints, relying on its deep integration with Windows and Office 365 to protect against malware and viruses. Organizations benefit from its real-time detection and comprehensive management capabilities, particularly in hybrid environments where diverse digital infrastructures need safeguarding.

Microsoft

Qualys Multi-Vector EDR is designed for real-time threat detection and response, offering comprehensive visibility into potential security breaches across endpoints.

This solution integrates seamlessly with other Qualys modules, facilitating automated workflows that streamline incident management and enhance efficiency in monitoring and mitigating cyber threats. With features like real-time monitoring, detailed reporting, and proactive alerting, security teams can quickly identify and address vulnerabilities. While appreciated for its scalability and ease of deployment, users suggest improvements in integration, reporting, and configuration to further enhance its capabilities.

What are the key features of Qualys Multi-Vector EDR?

Real-time Threat Detection: Continuously monitors endpoints to detect potential threats immediately.
Seamless Integration: Integrates with other Qualys modules and existing systems for streamlined operations.
Automated Response: Automates incident response workflows to enhance efficiency and reduce manual tasks.
Detailed Reporting: Provides in-depth reports to support proactive security measures and quick remediation.
Scalability: Suitable for businesses of varying sizes due to its scalable architecture.

What are the benefits and ROI to look for when evaluating Qualys Multi-Vector EDR?

Enhanced Security: Comprehensive threat detection ensures robust security measures.
Improved Efficiency: Automated workflows save time and reduce manual intervention.
Quick Remediation: Real-time alerts and detailed reports facilitate swift vulnerability mitigation.
Cost-effective Deployment: Scalable and resource-efficient architecture suitable for businesses large and small.

Qualys Multi-Vector EDR is implemented across industries such as finance, healthcare, and retail, where real-time threat detection and automated response are critical. Its ability to integrate with existing systems and provide detailed reporting makes it a valuable asset for enhancing cybersecurity measures in diverse environments.

Qualys

Sample Customers

CBI Health Group, University Honda, VakifBank

Petrofrac, Metro CSG, Christus Health

Pacific Dental Services, Greenhill and Co, Heffernan Insurance Brokers

Buyer's Guide

Endpoint Detection and Response (EDR)

September 2026

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