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ThreatLocker Zero Trust Endpoint Protection Platform vs Trellix Network Detection and Response comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Jan 11, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.9
ThreatLocker Zero Trust boosts ROI by blocking threats, reducing risks, and enhancing security with seamless integration and quick adaptation.
Sentiment score
7.6
Trellix enhances security and productivity, offering nearly 200% ROI, faster threat detection, and broad client satisfaction.
If something were to happen without ThreatLocker, the cost would be huge, and thus, having it is definitely worth it.
Tier 1 IT Engineer at a retailer with 11-50 employees
The main return on investment is peace of mind, knowing that with ThreatLocker on any endpoint, it will almost always block all malicious code or exploits, even zero-day exploits.
Project Engineer at Lutz M&A, LLC
It keeps malware, Trojans, and ransomware at bay.
Technical Engineer at Cloud 1 Solutions
 

Customer Service

Sentiment score
7.7
ThreatLocker offers exceptional 24/7 customer service with fast issue resolution, highly rated by users for speed and expertise.
Sentiment score
7.2
Trellix Network Detection and Response offers reliable 24/7 support, though some users desire quicker response times during incidents.
They have been very responsive, helpful, and knowledgeable.
Systems Security Analyst & Deputy Security Officer at a financial services firm with 201-500 employees
I would rate their customer support a ten out of ten.
Director, Managed Services at a consultancy with 11-50 employees
Their support is world-class.
Supervisor, Client Security at a consultancy with 11-50 employees
Technical support needs improvement as sometimes engineers are not available promptly, especially during high-severity incidents.
Information Security Engineer at Nhq Distribution Ltd
The customer support for Trellix Network Detection and Response is great.
Agente De Servicios Técnicos at a computer software company with 11-50 employees
 

Scalability Issues

Sentiment score
8.0
ThreatLocker scales efficiently, handling thousands of endpoints easily, with updates and flexible deployment supporting diverse organizational needs.
Sentiment score
7.9
Trellix Network Detection and Response offers reliable cloud scalability, supporting diverse industries with high satisfaction despite varied admin support.
I started off with just the servers, and within a month and a half, I set up the entire company with ThreatLocker.
Technical Engineer at Cloud 1 Solutions
It seems to primarily operate on the endpoints rather than at a central location pushing out policies.
Systems Security Analyst & Deputy Security Officer at a financial services firm with 201-500 employees
I would rate it a ten out of ten for scalability.
Project Engineer at Lutz M&A, LLC
 

Stability Issues

Sentiment score
7.4
ThreatLocker Zero Trust Platform offers stable performance, minimal downtime, quick issue resolution, and seamless integration with operating systems.
Sentiment score
7.8
Trellix Network Detection and Response is reliable, with minor issues in performance requiring maintenance and expertise for optimal use.
For five years, we have not had a problem.
Supervisor, Client Security at a consultancy with 11-50 employees
Once deployed, it downloads the policies locally, so even if the computer doesn't have internet, it doesn't matter.
Information Cybersecurity Technology Specialist at Freez.it
It has been very stable, reliable, and accessible.
COO at Panda Technology
 

Room For Improvement

ThreatLocker could improve by enhancing training, UI, reporting, integration, and support to address approval and update challenges.
Trellix Network Detection and Response needs improved customization, integration, reporting, threat intelligence, AI, support, and dashboard visibility.
Controlling the cloud environment, not just endpoints, is crucial.
COO at Panda Technology
This is problematic when immediate attention is needed.
Senior System Administrator at Molders Group Limited
Comprehensive 24-hour log monitoring is a valuable enhancement for both business and enterprise-level users.
IMS ENGINEER at a tech vendor with 1,001-5,000 employees
There should be improvements in AI intelligence, faster decision-making, and a more responsive technical support team.
Information Security Engineer at Nhq Distribution Ltd
I would like to see in Trellix Network Detection and Response more explanation about some details of the threat.
Agente De Servicios Técnicos at a computer software company with 11-50 employees
 

Setup Cost

ThreatLocker offers a cost-effective Zero Trust solution with flexible pricing, appreciated for transparency and easy setup across clients.
Trellix Network Detection and Response is perceived as costly, but valued for effective threat detection and competitive pricing.
After conversations with other partners, it became clear we underpriced it initially, which caused most of our issues.
Director, Managed Services at a consultancy with 11-50 employees
We are moving towards the Unified solution, where they basically bundle everything together, providing us better stability with the ability to bring in new product offerings without having to go back to the customer and say, 'This is going to cost you.'
Supervisor, Client Security at a consultancy with 11-50 employees
I had a really good deal at the time, and it continues to be cost-effective.
Cyber Security Specialist at Bremmar Consulting
 

Valuable Features

ThreatLocker enhances security and reduces costs with application control, instant support, intuitive interface, and comprehensive training resources.
Trellix excels in zero-day threat detection, automatic responses, and enhancing security infrastructure with user-friendly dashboards and sandboxing.
ThreatLocker Zero Trust Endpoint Protection Platform's ability to block access to unauthorized applications has been excellent.
Cyber Security Specialist at Bremmar Consulting
It protects our customers.
CTO at Zettabytes
The major benefit is fewer breaches overall, as nothing can be run without prior approval. This helps my company protect its data and secure itself effectively.
Tier 1 IT Engineer at a retailer with 11-50 employees
Trellix NDR provides an essential defense by automatically responding to network incidents that firewalls may not catch.
Information Security Engineer at Nhq Distribution Ltd
What makes Trellix Network Detection and Response stand out for me compared to other tools is the way you can detect threats. It is very easy and comfortable to use, and the detection shows clearly on the screen, which is very easy to understand.
Agente De Servicios Técnicos at a computer software company with 11-50 employees
 

Categories and Ranking

ThreatLocker Zero Trust End...
Ranking in Advanced Threat Protection (ATP)
6th
Average Rating
9.2
Reviews Sentiment
7.4
Number of Reviews
40
Ranking in other categories
Network Access Control (NAC) (4th), Endpoint Protection Platform (EPP) (6th), Application Control (1st), ZTNA (4th), Ransomware Protection (1st)
Trellix Network Detection a...
Ranking in Advanced Threat Protection (ATP)
12th
Average Rating
8.4
Reviews Sentiment
7.3
Number of Reviews
40
Ranking in other categories
Network Detection and Response (NDR) (10th)
 

Mindshare comparison

As of January 2026, in the Advanced Threat Protection (ATP) category, the mindshare of ThreatLocker Zero Trust Endpoint Protection Platform is 2.7%, up from 1.9% compared to the previous year. The mindshare of Trellix Network Detection and Response is 3.9%, up from 3.8% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
ThreatLocker Zero Trust Endpoint Protection Platform2.7%
Trellix Network Detection and Response3.9%
Other93.4%
Advanced Threat Protection (ATP)
 

Featured Reviews

CL
Supervisor, Client Security at a consultancy with 11-50 employees
World-class support and highly effective for application control and elevation
Their product is solid. I have a hard time complaining much about it because when we do find little things, they are usually interface-related or related to things that would be nice to have. Their idea portal, unlike so many other vendors we deal with, shows movement. At least four to eight features of ThreatLocker exist because I made a request in the last five years, and it became a feature of the actual product. When it comes to improvements, we moved the product as customers, and we got to move the product by making suggestions. They seem to be very reactive to it, so there is not a whole lot that they actively need to change right now. It is one of those situations where when we run into something that would be nice to have, it happens. They make it work.
Jose Vargas - PeerSpot reviewer
Agente De Servicios Técnicos at a computer software company with 11-50 employees
Has improved threat detection workflows and supports seamless customer monitoring
The best features Trellix Network Detection and Response offers include very good threat detection, and I believe that it is one of the best XDR tools. For example, ePO and XDR components are very comfortable and similar to many other tools for this type of monitoring, and I have received very good feedback for this tool. What makes Trellix Network Detection and Response stand out for me compared to other tools is the way you can detect threats. It is very easy and comfortable to use, and the detection shows clearly on the screen, which is very easy to understand. Regarding the features, I think that the integration with other platforms is very comfortable with the customer because we can integrate it with any switch or firewall, and it is comfortable to add this tool. Trellix Network Detection and Response has positively impacted my organization as I have improved my knowledge about detection and response. I have already used some other tools such as CrowdStrike and Umbrella, but Trellix is one of the best that I have tested. I believe that for my organization, Trellix has helped a lot with detection and supported our customers effectively. Trellix Network Detection and Response is a great tool that integrates with a lot of security tools such as Palo Alto, which is a good firewall. If you have these types of tools, your organization would benefit greatly.
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Top Industries

By visitors reading reviews
Computer Software Company
22%
Retailer
8%
Manufacturing Company
8%
Financial Services Firm
7%
Comms Service Provider
13%
Manufacturing Company
12%
Financial Services Firm
11%
Government
10%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business32
Midsize Enterprise4
Large Enterprise3
By reviewers
Company SizeCount
Small Business20
Midsize Enterprise8
Large Enterprise19
 

Questions from the Community

What do you like most about ThreatLocker Allowlisting?
The interface is clean and well-organized, making it simple to navigate and find what we need.
What is your experience regarding pricing and costs for ThreatLocker Allowlisting?
Pricing, setup costs, and licensing have been pretty accessible and manageable. It was not too expensive to get started, especially at a small scale for a smaller MSP. It is very accessible, easy t...
What needs improvement with ThreatLocker Allowlisting?
Going with the theme of ThreatLocker Zero Trust Endpoint Protection Platform being a one-stop shop where they have just about everything, and they have a really good product stack as is. However, t...
What do you like most about FireEye Network Security?
We wanted to cross-reference that activity with the network traffic just to be sure there was no lateral movement. With Trellix, we easily confirmed that there was no lateral network involvement an...
What is your experience regarding pricing and costs for FireEye Network Security?
My experience with pricing, setup cost, and licensing for Trellix Network Detection and Response is very great.
What needs improvement with FireEye Network Security?
I would like to see in Trellix Network Detection and Response more explanation about some details of the threat, and I wish it had more actions that you can take to contain the host or move it some...
 

Also Known As

Protect, Allowlisting, Network Control, Ringfencing
FireEye Network Security, FireEye
 

Overview

 

Sample Customers

Information Not Available
FFRDC, Finansbank, Japan Advanced Institute of Science and Technology, Investis, Kelsey-Seybold Clinic, Bank of Thailand, City of Miramar, Citizens National Bank, D-Wave Systems
Find out what your peers are saying about ThreatLocker Zero Trust Endpoint Protection Platform vs. Trellix Network Detection and Response and other solutions. Updated: December 2025.
881,082 professionals have used our research since 2012.