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CylanceENDPOINT vs Microsoft Defender for Endpoint comparison

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Executive Summary

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cortex XDR by Palo Alto Net...
Sponsored
Ranking in Endpoint Protection Platform (EPP)
4th
Average Rating
8.6
Reviews Sentiment
6.7
Number of Reviews
122
Ranking in other categories
Endpoint Detection and Response (EDR) (5th), Extended Detection and Response (XDR) (3rd), Ransomware Protection (2nd), AI-Powered Cybersecurity Platforms (1st)
CylanceENDPOINT
Ranking in Endpoint Protection Platform (EPP)
63rd
Average Rating
8.0
Reviews Sentiment
7.7
Number of Reviews
1
Ranking in other categories
No ranking in other categories
Microsoft Defender for Endp...
Ranking in Endpoint Protection Platform (EPP)
2nd
Average Rating
8.2
Reviews Sentiment
7.0
Number of Reviews
212
Ranking in other categories
Advanced Threat Protection (ATP) (6th), Anti-Malware Tools (1st), Endpoint Detection and Response (EDR) (3rd), Microsoft Security Suite (3rd), Agentic Endpoint Security (3rd)
 

Mindshare comparison

As of November 2026, in the Endpoint Protection Platform (EPP) category, the mindshare of Cortex XDR by Palo Alto Networks is 3.8%, up from 3.6% compared to the previous year. The mindshare of CylanceENDPOINT is 0.3%, up from 0.1% compared to the previous year. The mindshare of Microsoft Defender for Endpoint is 6.4%, down from 9.5% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Endpoint Protection Platform (EPP) Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Endpoint6.4%
Cortex XDR by Palo Alto Networks3.8%
CylanceENDPOINT0.3%
Other89.5%
Endpoint Protection Platform (EPP)
 

Featured Reviews

ABHISHEK_SINGH - PeerSpot reviewer
Senior Process Expert at A.P. Moller - Maersk
Gained full visibility and streamlined threat detection through behavior-based insights and AI integration
Initially, we got to have a lot of false positives when we onboarded, but nowadays it's quite smooth. We have fine-tuned our security policies and allowed different levels of policies to get rid of those false positives. Currently, we are getting a fairly good amount of incidents that are not false positives or benign, but actionable items. The process is streamlined. In the initial days, the operations used to get involved in a lot of benign and other activities, but now the process is streamlined. We are leveraging the auto-detection and remediation plans. The operations teams are now more involved in other business roles as well, not just looking into the logs and fetching out what's happening there. They have fixed a lot of things. Initially, they didn't have IAC code drift detection, cloud posture management, or security posture management, but they have those now. They purchased different vendors and did a merger with that. They have now Prisma Cloud that gets integrated and now they are working with Cortex Cloud. Everything that was negative has now been addressed, and the product altogether looks to be in a very better and mature shape now. Currently, it's more or less detecting the workloads with AI-based best practices. Since most organizations are consuming AI agents and other things, we are looking forward to seeing what other feature enhancements Palo Alto can support in that.
Raphael Haroun  Ikyagh - PeerSpot reviewer
Network Administrator at Letshego
Stable, good for malware detection and prevention
I use it for general endpoint protection and the usual stuff like malware detection and prevention It secures my environment.  One thing that could be easier is initiating scans. If I want to scan an extra drive, it should be more straightforward. It's a bit clunky. I have been using it for…
Robert Arbuckle - PeerSpot reviewer
Security Analyst III at a healthcare company with 10,001+ employees
Automatically isolates threats and integrates with logging to reduce response time
Overall, I would evaluate the Microsoft support level that I receive at probably about a seven, but that depends on the day. It has been spotty. We have had issues where the urgency level of the Microsoft support is not as high as ours, especially during a data breach or potential data breach situation. We have had issues with some of the offshore support being lackluster. One specific thing that comes to mind is we were on a support call with our CISO on the call, and the Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, "Just to set expectations, my lunch break is in an hour and I am going to go away then." For us, it was already ten o'clock at night and we had been working on this for a couple of hours, trying to get a security engineer on with us. For him to tell us that he was going to go away and have lunch, it was, "Okay, but go find somebody else if you need to." It was just the lackluster approach, and it seemed like he did not really care. We seem to get a lot of this when we get non-Microsoft support. I can identify areas for improvement with Microsoft Defender for Endpoint, as it is kind of a convoluted mess to try to take care of false positives. Especially when they have been identified as false positives but they keep going off over and over again. It is great for my pocketbook because it generates a lot of on-call action, but I would really prefer more sleep at two o'clock in the morning than dealing with false positives. I would say that the unified portal for managing Microsoft Defender for Endpoint is suitable for both teams as they are all in there. It would be great if they would stop moving things around and renaming things, which makes sense. The new XDR portal is pretty nice. Being able to have it central again inside of the regular Security Center without having to open up two windows is helpful. Overall, I think it is pretty good. There is always going to be something that could be improved, such as alerting and the ability to modify alerts would be a little bit helpful to have. Being able to add more data into the alerts and turn off alerts that are not as useful would be beneficial. It is hard to say what the quantitative impact the security exposure management feature has had on our company's security, because a lot of it is kind of subjective. I think we are sitting at around a fifty percent score still, and a lot of it is just kind of unusual circumstances that we cannot really implement without breaking the organization.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The tool is designed to scale for large enterprises and handle large volumes of data."
"The most valuable feature of Cortex XDR by Palo Alto Networks is its machine-learning capabilities. Additionally, there is full integration with other solutions."
"I generally believe that Cortex XDR by Palo Alto Networks is probably the best in the market right now."
"The product is very good, it has caught a lot of exploits that most products would not."
"The solution allows control over the user and his machine through Cortex XDR security policies."
"Overall, it's a great platform; it integrates very well with other solutions from Palo Alto and also with our vendors, the ease of use is excellent, I love the root cause analysis from Cortex, which is amazing, and in a few clicks you can have the full root cause."
"My advice for others looking into using Cortex is that it is very easy to use and very useful for the customer environment, whether it's a public or private one."
"We can use Cortex XDR to get the entire graph of the incidents from source to destination, and we can take remedial action."
"It secures my environment."
"Microsoft Defender Antivirus is easy to install."
"Microsoft Defender can block some viruses or malware, so it can protect my files, and it can save files on Office 365 OneDrive, where I use encryption for some files and can then recover them from OneDrive."
"Microsoft Defender for Endpoint has enabled us to secure devices even when they are off of the organization's premises and has helped improve and mitigate security risks across the organization."
"The most valuable aspect lies in its automation capabilities, particularly within security automation."
"If I didn't have the integrated pieces of Microsoft Defender, to do the same amount and be on top of things, I would probably need two FTEs."
"The virus scanning capability is excellent, and it feeds all the logs into the Microsoft 365 Defender portal, making them easy to search for."
"The most important feature is the way it monitors the threats and blocks them. About 10 days ago, we were implementing SOC for a particular client. The SOC was not yet implemented, but they had Microsoft Defender. That organization was hit by some ransomware, but the hacker could not succeed. Because of the EDR, the hacker could not install the hacking tools. They were trying to do that, but Microsoft Defender completely blocked that. The hacker could log into the system, but they could not install anything."
"I would recommend this solution to others if they don't have many third-party tools."
 

Cons

"We have found that there are times Cortex XDR by Palo Alto Networks does not detect some of the viruses, we have to use another protection solution called Kaspersky."
"Cortex XDR by Palo Alto Networks is a strong tool, but it is true that digesting information sometimes makes the tool go a little bit slower."
"Basically, they don't provide customer support tools just to investigate the logs."
"I don't like that they have different types of licenses. For example, if users select a license, they think they will have all the platforms they need to improve their network or security. But after some time, Palo Alto Networks changed their licensing, and some of the features that, for example, were free at the beginning now have a cost. I think the integration can be improved. For example, a lot of tools are just integrated through APIs."
"The tool needs to be improved in terms of integration and interface."
"I feel that it should not be a licensed activity because a feature should allow us to see applications running on end devices."
"If he is using a smaller company, he can depend on some other tools because Cortex XDR by Palo Alto Networks is a bit expensive."
"Every 30 or 40 days, there's a new version and we need to go and make sure our customer's laptops are upgraded."
"One thing that could be easier is initiating scans."
"Windows Firewall is integrated with Windows Defender. Over the last few days, I have had a problem with defining a wildcard on Windows Firewall."
"One thing that was lacking in Defender was web filtering. Its web filtering wasn't as comprehensive. Sophos was a little bit better than Defender for blocking URLs or installing programs."
"The solution can be more user-friendly."
"Another concern is ransomware, whether people can penetrate and encrypt my data or steal my credit card/banking information."
"Something that is unique to Microsoft is its licensing model. When you go out and you buy McAfee or Symantec, you know what you're getting out of the box, but with Microsoft, often, when you're looking to achieve a certain set of capabilities, those capabilities are spread across different products. You might try to do something you could do with CrowdStrike, but then find out that you also need to purchase Microsoft Defender for Identity or Microsoft Defender for Azure. You realize that when they talk about what they can offer within the Microsoft platform, it's really the suite of investments. So, sometimes, you may find yourself buying Defender for Endpoint thinking that it matches CrowdStrike, but then you find that Microsoft really needs to sell you something else. One plus one will equal three, but when you have a very concise platform, such as CrowdStrike, you know what you're going to get."
"There is a lot of information to take in, and the portals tend to change quickly due to the fast-paced nature of the industry."
"There is some functionality that is not quite there yet."
"Windows Firewall is integrated with Windows Defender. Over the last few days, I have had a problem with defining a wildcard on Windows Firewall. For example, I wanted to pull out the connection of my program and install a software package with a lot of executable files. I wanted to prevent it from accessing the internet. I could not select executables by using a wildcard. I had to select a single executable with its full name."
 

Pricing and Cost Advice

"I don't have any issues with the pricing. We are satisfied with the price."
"In terms of the cost Cortex XDR by Palo Alto Networks is very expensive because we are a Mexican company and when you translate dollars to pesos the cost is very high. The solution is very expensive for Mexican companies. I understand that they have international prices, but I do not think it offsets the price enough for many companies in countries, such as Mexico. The amount it is reduced is not a massive percentage."
"The price of the solution could be reduced. I have customers that have voiced that the solution is good for the value but if I want to sell more of the solution the price reduction would help."
"The price of the product is not very economical."
"It's the most expensive solution, but features-wise, it's quite strong. It's very good for protection, so the results are very good in the case of protection. I would rate it a two out of ten in terms of pricing."
"It is "expensive" and flexible."
"Cortex XDR by Palo Alto Networks is an expensive solution."
"It is cost-effective compared to similar solutions. It fits for the small businesses through to the big businesses."
Information not available
"The solutions price could be cheaper."
"We are using the free version."
"There is no license needed, the solution comes with Microsoft Windows."
"We have the E5 security license, and the solution comes with that."
"The solution comes as part of Microsoft Windows."
"This solution is part of an enterprise license we have."
"The solution is free."
"It is an expensive solution. It would be nice if it could be included with the Microsoft Office package."
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Top Industries

By visitors reading reviews
Comms Service Provider
14%
Outsourcing Company
12%
Construction Company
10%
Manufacturing Company
10%
No data available
Manufacturing Company
10%
Financial Services Firm
9%
Comms Service Provider
8%
Outsourcing Company
8%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business50
Midsize Enterprise21
Large Enterprise57
No data available
By reviewers
Company SizeCount
Small Business82
Midsize Enterprise44
Large Enterprise97
 

Questions from the Community

Cortex XDR by Palo Alto vs. Sentinel One
Cortex XDR by Palo Alto vs. SentinelOne SentinelOne offers very detailed specifics with regard to risks or attacks. ...
Comparing CrowdStrike Falcon to Cortex XDR (Palo Alto)
Cortex XDR by Palo Alto vs. CrowdStrike Falcon Both Cortex XDR and Crowd Strike Falcon offer cloud-based solutions th...
How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface,...
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Which offers better endpoint security - Symantec or Microsoft Defender?
We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior sol...
How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?
The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never pu...
What is your experience regarding pricing and costs for Microsoft Defender for Endpoint?
We have been discussing pricing, setup cost, and licensing, and we are currently on an E3. We are discussing going to...
 

Also Known As

Cyvera, Cortex XDR, Palo Alto Networks Traps
No data available
Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus
 

Interactive Demo

Demo not available
Demo not available
 

Overview

 

Sample Customers

CBI Health Group, University Honda, VakifBank
Information Not Available
Petrofrac, Metro CSG, Christus Health
Find out what your peers are saying about SentinelOne, Microsoft, CrowdStrike and others in Endpoint Protection Platform (EPP). Updated: October 2026.
920,769 professionals have used our research since 2012.