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Microsoft Defender for Endpoint vs Trellix Advanced Threat Defense comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Endp...
Ranking in Advanced Threat Protection (ATP)
5th
Average Rating
8.2
Reviews Sentiment
7.0
Number of Reviews
212
Ranking in other categories
Endpoint Protection Platform (EPP) (2nd), Anti-Malware Tools (1st), Endpoint Detection and Response (EDR) (3rd), Microsoft Security Suite (3rd)
Trellix Advanced Threat Def...
Ranking in Advanced Threat Protection (ATP)
23rd
Average Rating
7.8
Reviews Sentiment
5.6
Number of Reviews
9
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of June 2026, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Endpoint is 5.8%, down from 7.5% compared to the previous year. The mindshare of Trellix Advanced Threat Defense is 2.0%, up from 1.4% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Endpoint5.8%
Trellix Advanced Threat Defense2.0%
Other92.2%
Advanced Threat Protection (ATP)
 

Featured Reviews

Robert Arbuckle - PeerSpot reviewer
Security Analyst III at a healthcare company with 10,001+ employees
Automatically isolates threats and integrates with logging to reduce response time
Overall, I would evaluate the Microsoft support level that I receive at probably about a seven, but that depends on the day. It has been spotty. We have had issues where the urgency level of the Microsoft support is not as high as ours, especially during a data breach or potential data breach situation. We have had issues with some of the offshore support being lackluster. One specific thing that comes to mind is we were on a support call with our CISO on the call, and the Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, "Just to set expectations, my lunch break is in an hour and I am going to go away then." For us, it was already ten o'clock at night and we had been working on this for a couple of hours, trying to get a security engineer on with us. For him to tell us that he was going to go away and have lunch, it was, "Okay, but go find somebody else if you need to." It was just the lackluster approach, and it seemed like he did not really care. We seem to get a lot of this when we get non-Microsoft support. I can identify areas for improvement with Microsoft Defender for Endpoint, as it is kind of a convoluted mess to try to take care of false positives. Especially when they have been identified as false positives but they keep going off over and over again. It is great for my pocketbook because it generates a lot of on-call action, but I would really prefer more sleep at two o'clock in the morning than dealing with false positives. I would say that the unified portal for managing Microsoft Defender for Endpoint is suitable for both teams as they are all in there. It would be great if they would stop moving things around and renaming things, which makes sense. The new XDR portal is pretty nice. Being able to have it central again inside of the regular Security Center without having to open up two windows is helpful. Overall, I think it is pretty good. There is always going to be something that could be improved, such as alerting and the ability to modify alerts would be a little bit helpful to have. Being able to add more data into the alerts and turn off alerts that are not as useful would be beneficial. It is hard to say what the quantitative impact the security exposure management feature has had on our company's security, because a lot of it is kind of subjective. I think we are sitting at around a fifty percent score still, and a lot of it is just kind of unusual circumstances that we cannot really implement without breaking the organization.
PP
RSSI at SDIS49
Ensuring long-term reliability while seeking internal email management enhancements
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it's a cloud product, so we don't really know the version as it's always updated. We have not had any problem, but it's difficult to report on what's going on because some days they can wash out perhaps 100 mails, and then it's difficult to say how many attacks you have reached. The right email has been washed out and then nobody has complained. We do not use the Threat Visualization feature; as we are in MX, the mail is washed out before it is in the mail inbox of the user, thus avoiding any problem requiring a reservation. In fact, there is no integration with existing security frameworks. The only problem we can have is that as we have no API interface, there is no inspection of internal mail. I rate Trellix Advanced Threat Defense a nine out of ten.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"It integrates very well with all Windows workstations or other Microsoft Endpoint products. It also works quite well. So far, I have not had any issue that hasn't been sorted out. It doesn't use too many resources, so you don't have to install different things."
"The main thing I like about Microsoft Defender for Endpoint is that you can integrate it with or deploy it with Intune, so it's really easy to deploy without needing to bring in any third-party solution."
"The performance of Microsoft Defender for Endpoint has been good."
"I find the layer protection and real-time protection very useful because when I launch a program, I always have a notification and an alarm."
"It's one of the best antiviruses on the market."
"Endpoint's most valuable feature is deep analysis."
"I enjoy using the live response feature, which allows me to remotely access different endpoints and investigate malicious files, such as malware that people may have downloaded, and other related issues."
"The whole bundle of the product, which is similar to other Microsoft products, is valuable. Ten years ago, you had third-party stuff for different things. You had one solution for email archiving and another third-party one for something else. Nowadays, Microsoft Office covers all the stuff that was formerly covered by third-party solutions. It is the same with antivirus. The functionality is just basic. You have the scanning, and then you also have a kind of cloud-based protection and reporting about your environment. With Microsoft Security Center, you have a complete overview of your environment. You know the software inventory, and you have security recommendations. You can not only see that the antivirus is up to date; you can also see where are the vulnerabilities in your system. Microsoft Security Center tells you where you have old, deprecated software and what kind of CVEs are addressed. It's really cool stuff."
"It is very scalable."
"I see ROI, as it stops in excess of twenty-five malware events per month, all of which could be critical to the business."
"I recommend this solution because of its ease of use."
"Its greatest strength is the DXL client which can rapidly disseminate attack information to all clients via the McAfee Agent instead of going through the ePO server."
"It was easy to set up initially."
"The most valuable features are the administration console and its detection and response module."
"Provides good exfiltration, and is an all-in-one product."
"If a system admin can put in the patience to read and constantly update the ePO system in terms of rules, enforcing them at regular intervals, you can safely go to sleep every night."
 

Cons

"Monitoring can always be better, onboarding can be a little bit faster, log collection could be easier, they could streamline the dashboard. They could maybe split it up into different workspaces and have the ability to segment groups a little bit more."
"We encountered some misbehavior between Microsoft Office Suite and Defender. We had issues of old macros being blocked and some stuff going around the usage of Win32 APIs. There is some improvement between the Office products and Defender, and there is a bunch of stuff that you can configure in your antivirus solutions, but you have several baselines, such as security baselines for Edge, security baselines for Defender, and security baselines for MDM. You have configuration profiles as well. So, there a lot of parts where we can configure our antivirus solution, and we're getting conflicting configurations. This is the major part with which we're struggling in this solution. We are having calls and calls with Microsoft for getting rid of all configuration conflicts that we have. That's really the part that needs to be improved."
"The reporting in Microsoft Defender for Endpoint should improve. The solution has limited features."
"Additional security would be beneficial."
"Microsoft Defender for Endpoint's licensing is confusing. It has conflicting information on the website. We also faced integration issues with other systems. It makes laptops slower than traditional antivirus systems."
"The profiling method currently in use is not very user-friendly and has ample scope for improvement."
"I'm not too sure of its current capabilities, but I'm pretty sure they are doing a good job on Windows and Mac. However, I'm not sure whether they covered Linux. If I remember correctly, Microsoft Defender didn't have anything proper on Linux back then, but if they have improved it from that aspect, it would already be ticking all the boxes."
"It's not quite a mature solution just yet. It needs more time to grow and develop."
"The support on their side is not readily available. It takes a while."
"The only problem we can have is that as we have no API interface, there is no inspection of internal mail."
"Make the ATD appliance a part of the whole product offering and take the whole thing onto the cloud."
"There could be a tool that automatically updates all-new Microsoft IPs, which are available for free to connect to the client."
"This solution needs to be made "cloud ready"."
"The initial setup was industry standard complex. It takes awhile and has a lot of planning involved. It could be simplified with product redesign."
"We'd like them to be better at dealing with script threats."
"This product does the job, but it is not flexible enough to do new environments yet."
 

Pricing and Cost Advice

"We went for Microsoft Defender once we were informed that it would be part of our Office 365 package. So, we combined the licensing for the OS with Office 365. Yeah. We thought it was a good bargain."
"The license for Microsoft Windows covers Microsoft Defender for Endpoint."
"The price was a problem for me three years ago, but they improved their E3, E5, and a la carte licensing. In other words, you have to get all of E5. That used to be a problem because you had E3, Defender, and guardrails, but you needed an E5 license to get the management suite and the analytics. It's more flexible now. You can switch from a la carte to the entire suite when it starts to make sense. It's becoming more economically competitive to go that route."
"It is free. It is included in Windows 10."
"The solution comes as a part of Windows 10 and it is covered under its license."
"The solution is an open source version and was free with a paid version of Windows 10."
"For me, the pricing is very good, but for management it's very expensive. Other solutions are less expensive. But when I present all the information and all the reports they say, "Well, it's expensive, but the cost-benefit is very good.""
"We are using the free version."
"The product is expensive, but it is better than the rest of them in the industry."
"Our licensing fees for this solution are approximately one million dollars per year."
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Top Industries

By visitors reading reviews
Manufacturing Company
10%
Financial Services Firm
10%
Computer Software Company
9%
Comms Service Provider
8%
Construction Company
17%
Financial Services Firm
12%
Comms Service Provider
10%
Outsourcing Company
10%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business82
Midsize Enterprise45
Large Enterprise96
By reviewers
Company SizeCount
Small Business3
Midsize Enterprise4
Large Enterprise5
 

Questions from the Community

How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface, applies behavioral-based endpoint protection and response, and includes risk-ba...
Which offers better endpoint security - Symantec or Microsoft Defender?
We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior solution. Microsoft Defender for Endpoint is a cloud-delivered endpoint security s...
How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?
The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never push your machine hardware to "test", you don't have the usual "scan now" feature ...
What needs improvement with McAfee Advanced Threat Defense?
I would like to see an API interface for internal email and control of outgoing email to make it closer to 10. It's necessary; today we have an MX interface, and it would be interesting to have an ...
What is your primary use case for McAfee Advanced Threat Defense?
We are working with Palo Alto products, specifically firewalls. We are only using Palo Alto Firewalls and not Cortex. With FireEye and Trellix, we only work with ETP now because the NDR function wh...
What advice do you have for others considering McAfee Advanced Threat Defense?
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it'...
 

Also Known As

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus
McAfee Advanced Threat Defense
 

Interactive Demo

Demo not available
 

Overview

 

Sample Customers

Petrofrac, Metro CSG, Christus Health
The Radicati Group, Florida International University, MGM Resorts International, County Durham andDarlington NHS Foundation Trust
Find out what your peers are saying about Microsoft Defender for Endpoint vs. Trellix Advanced Threat Defense and other solutions. Updated: June 2026.
900,838 professionals have used our research since 2012.