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Microsoft Defender for Office 365 vs Trend Micro InterScan Messaging Security [EOL] comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Jun 3, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (2nd), Email Security (2nd), Advanced Threat Protection (ATP) (3rd), Microsoft Security Suite (8th), Secure Email Gateway (SEG) (2nd)
Trend Micro InterScan Messa...
Average Rating
7.0
Reviews Sentiment
7.1
Number of Reviews
3
Ranking in other categories
No ranking in other categories
 

Featured Reviews

Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.
Abdul  Waris - PeerSpot reviewer
Tech Operations at Martin Dow Limited
Deploy features like DLP and BEC for enhanced security
Multiple clients are using email security. We provide solutions based on what they need, and we configure them accordingly as per the requirement With Trend Micro email security gateway, we can deploy features like DLP and BEC. It includes Office 365 protection and sandboxing. This provides…

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The initial setup is straightforward. You just add the license, click it, and then you can set up the rules. It is quite simple."
"Microsoft so far has been good; we haven't faced any kind of disruption or anything else, it's a good product and good platform, I must say, and overall it's a good product and good service and we haven't dealt with bugs or glitches."
"The benefit that stands out to me is the ability for multiple individuals to collaborate simultaneously within the same document. Additionally, there is the option to save the document directly in the integrated OneDrive or SharePoint."
"The most valuable feature of Microsoft Defender for Office 365 is the ease of use."
"Since we have started using the solution, there have been fewer compromises."
"The two main features that prove most beneficial for us are URL scanning and attachment scanning."
"The product is not resource-intensive."
"The feature I like the most about Microsoft Defender for Office 365 is that it typically runs in the background—you do not know it is there until you need to access it."
"With Trend Micro email security gateway, we can deploy features like DLP and BEC."
"The solution provides protection with its Email Track Records and Machine Manual features."
"The technical support services are excellent."
 

Cons

"Microsoft Defender for Office 365 is not up to the mark in comparison with Wiz or Palo Alto."
"Configuration at the mid-level could be improved for the support team."
"Microsoft wants its well-paying customers to finish testing some of its half-baked products, find bugs, and report bugs back to Microsoft's team, which is a little frustrating for those who have to manage it and roll it up to thousands of people across the organization."
"Configuring the default strategies and policies in Microsoft Defender for Cloud Apps generates a lot of noise and false positives."
"There is room for improvement in terms of reporting."
"The certification training for Defender for 365 needs to be deeper and incorporate Sentinel. I took all the security courses except one, and Sentinel isn't included."
"Sometimes, phishing emails manage to pass through the filter, so the system needs to enhance its phishing email detection capabilities."
"In the areas of improvement for Microsoft Defender for Office 365, the console is the biggest challenge for me."
"The product's pricing could be more flexible."
"The solution's pricing could be improved."
"There is room for improvement in content filtration, expressions, file sharing, and policy configuration."
 

Pricing and Cost Advice

"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"I was working in the government and it was too expensive for us to use our Microsoft products."
"It's a user-base subscription."
"I know that the product is incredibly expensive."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."
"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
"The solution could be better by simplifying the business model of their licensing. It was hard to figure out how to get the licensing done for the environment, initially."
"Trend Micro is an expensive solution."
"I rate Trend Micro InterScan Messaging Security’s pricing a seven out of ten."
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920,574 professionals have used our research since 2012.
 

Top Industries

By visitors reading reviews
Computer Software Company
11%
Manufacturing Company
10%
Financial Services Firm
8%
Comms Service Provider
7%
Performing Arts
16%
Construction Company
10%
Manufacturing Company
9%
Outsourcing Company
9%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
No data available
 

Questions from the Community

What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as a standalone product. It's very competitive compared to what competitors are ch...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware. We are seeing a lot more malware-less emails that Defender for Offi...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
What is your experience regarding pricing and costs for Trend Micro InterScan Messaging Security?
The price is a bit high because the market is highly competitive. Multiple platforms are available, so we have to choose based on comparison.
What needs improvement with Trend Micro InterScan Messaging Security?
There is room for improvement in content filtration, expressions, file sharing, and policy configuration. We could decrease the price in email security gateway and cloud security services.
What is your primary use case for Trend Micro InterScan Messaging Security?
Multiple clients are using email security. We provide solutions based on what they need, and we configure them accordingly as per the requirement.
 

Also Known As

MS Defender for Office 365
InterScan Messaging Security
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Copa Airlines, Air21, BookMyShow, Bulgarian American Credit Bank, Canadian Museum of History, CIBIL, Community National Bank, Dar Al-Handasah
Find out what your peers are saying about Proofpoint, Microsoft, Check Point Software Technologies and others in Email Security. Updated: October 2026.
920,574 professionals have used our research since 2012.