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Cisco Secure Email vs Microsoft Defender for Office 365 comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Feb 8, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cloudflare One
Sponsored
Ranking in Email Security
20th
Average Rating
8.8
Reviews Sentiment
6.7
Number of Reviews
22
Ranking in other categories
Secure Web Gateways (SWG) (15th), Data Loss Prevention (DLP) (21st), Cloud Access Security Brokers (CASB) (11th), Distributed Denial-of-Service (DDoS) Protection (7th), Software Defined WAN (SD-WAN) Solutions (13th), Access Management (12th), Bot Management (3rd), ZTNA as a Service (8th), ZTNA (3rd), Secure Access Service Edge (SASE) (10th), Remote Browser Isolation (RBI) (3rd)
Cisco Secure Email
Ranking in Email Security
5th
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
63
Ranking in other categories
Cisco Security Portfolio (6th)
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (9th), Secure Email Gateway (SEG) (1st)
 

Mindshare comparison

As of March 2026, in the Email Security category, the mindshare of Cloudflare One is 1.5%, down from 1.8% compared to the previous year. The mindshare of Cisco Secure Email is 5.2%, down from 6.9% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 8.8%, down from 13.5% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3658.8%
Cisco Secure Email5.2%
Cloudflare One1.5%
Other84.5%
Email Security
 

Featured Reviews

CV
Network Architect at IP Dimension
Cloud security has improved remote access and has reduced costs for smaller client sites
I have used Cloudflare One's Identity-Aware Proxy, and it is quite straightforward from what I have seen so far. The app registration on the Azure side integrates fully into Cloudflare, and I am very satisfied with that part because it is easy to set up. The integration of Cloudflare One's Secure Web Gateway and Zero Trust Network Access works without any issues. That part is pretty automatic, and if you complete the rest of the setup, it comes together by itself with no issues from my side. What makes it nice is that we can actually start replacing on-site firewalls at this stage for the smaller clients because it does not matter if they go to a coffee shop or work from home; they are still secured by the same connection. The hops get shorter and you get better latency. We have done testing to see if it is better. One thing that we did notice with our proof of concept with our current client is that they have people connecting from the UK. When they used their previous VPN solution, uploading CAD drawings and other files to the server took a long time. They mentioned that it is much quicker on Cloudflare One's solution. I definitely believe that is part of the improved performance, and I am satisfied with that as well. What is nice about Cloudflare One is that it makes the setup easier and also easier to train technicians to maintain it. Compared to legacy systems, we do not need to get fancy firewalls in place that are costly. That is definitely also a cost-saver with Cloudflare One.
KS
Technical Associate Network Security at Valuepoint Systems
Email security has protected financial data and provides clear tracking for every branch message
The areas of Cisco Secure Email that could be improved or enhanced are the slowness in the console. I don't think it was a database error or something, but we feel some slowness in configuring DLP and other content filters compared to other consoles. It may have been due to on-premises, but it was much noisy at some times while configuring DLP. When we tried to configure a DLP policy, the console became much slower. In that case, we cannot see what had happened in the mail which was blocked at that time. It may take nearly an hour to get back to normal while configuring policies. That is the major issue in the product.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Cloudflare is by far the most effective solution that I have come across."
"I'm very satisfied with the environment and the dashboard."
"Enables me to work from two locations."
"The blocking feature is very good."
"The capabilities of the software are strong enough for me to do what it's supposed to do. For me, we don't need to do a lot of configuration on our site. We just enable it and monitor it."
"Cloudflare Zero Trust Platform removes the risk of exposing the applications to the public."
"The best feature is rate limiting. If I'm expecting 500 visits per hour, Cloudflare will limit the requests if I suddenly get 50,000."
"It is a stable solution."
"Cisco's Secure Email integrates with Cisco Firewalls, utilizing the AMP as their anti-malware engine, which allows for information sharing between devices."
"It integrates with Active Directory and we can limit specific users to using specific applications."
"This solution provides some benefits, like comfortable access to TAC support. You get prompt support when working directly with Cisco."
"Initially, the most valuable feature for us was the SenderBase Reputation, because that reduced the number of emails that were even considered by the system by a huge number..."
"I love the Advanced Malware Protection feature. It works very well... The appliance has more security such as SDF, DKIM, DMARC, and encryption."
"I can customize the configuration and policies."
"Administration of the email domains and custom filters are easily done via the web interface."
"IronPort really helped with the mail filtering and load balancing between the Exchange servers they had."
"The two main features that prove most beneficial for us are URL scanning and attachment scanning."
"The insights provided with Microsoft Defender for Office 365 are helpful because it comes with the E5 license, and by default, we can use a lot of capabilities."
"Microsoft Defender for Office 365 is a stable solution."
"Microsoft Defender for Office 365 has decreased my time to detection and time to respond by one hundred percent."
"It has significantly decreased my time to detection and response."
"The most valuable feature of Microsoft Defender for Office 365 is the ease of use."
"One of the best features of the tool is its capability to aggregate insights from different workloads, basically from the Office 365 and endpoints part."
"Defender helps us prioritize threats across our organization."
 

Cons

"Cloudflare Zero Trust Platform needs to improve its documentation. It took time to do the implementation."
"The onboarding process can be improved a little bit."
"Our subscription plan for the solution has a limitation of bot signatures."
"The tool should provide on-premise versions. Currently, all versions are cloud-based."
"The software has automated alerts, but the automated alerts are not available in the mobile app."
"Lacks a VPN feature to provide a secure connection to the data center."
"Cloudflare DDoS has poor technical support."
"There are premium tier live service and lower tier live service, so we opted for the lower tier. But there is no medium tier where we pay a little extra and get a bit more service. So if that can be improved."
"I would rate the stability a six out of ten. We had multiple issues with the stability."
"I would like to see sandboxing for email, where suspicious emails received by the system are analyzed through online services."
"We have Microsoft and we have the E5 licenses, they have more EDR responses on certain emails. That's something that Cisco ESA on the cloud doesn't have. They don't do anything about MITRE attacks. They only detect if there is a malicious email or a threat and they remove it."
"In future releases, I would like to see two main improvements come to mind. First, the current solution requires maintaining two separate operating systems for FTD, which can be cumbersome. I'd love to see a single operating system for the FTD box."
"One of the things that Cisco could improve on with IronPort is the support. Cisco doesn't really have enough engineers who have full, hands-on knowledge of IronPort. Knowledge of it is not something you can find easily compared to other security appliances."
"They can do it better with web links, with the URLs. They have a technology called Outbreak but it doesn't work as well as we would like."
"The reporting functionality needs to be improved."
"I would like them to add some clustering or high availability features."
"Configuration requires going to a lot of places rather than just accessing one tab."
"I think that Microsoft Defender for Office 365 could be improved if it could use VirusTotal to compare the programs or anything that I download."
"There needs to be an improvement in integrating the product to work across multiple operating systems, and to have better support for non-Microsoft file types."
"There is a different console for different things; I just want one consolidated console."
"Microsoft security solutions work as expected. They are constantly updating the solutions to make them better. At the same time, the changes can impact a customer's environment, and we need to adjust settings. Sometimes we aren't aware of the changes, and nothing is pushed from the backend automatically."
"We noticed that from time to time, Microsoft's stability does have problems. Sometimes the service goes up and down. Sometimes they change without prior notice."
"One area for improvement is support, in terms of being able to reach them and, especially, technical support for configuration."
"Configuring the default strategies and policies in Microsoft Defender for Cloud Apps generates a lot of noise and false positives."
 

Pricing and Cost Advice

"The solution is not that expensive."
"The pricing is somewhere in the middle. I would rate the pricing a seven out of ten."
"The price tag is no longer $200,000, but rather $300,000 to $400,000. It's twice."
"The solution's pricing lacks transparency."
"The pricing of the solution is cheap. The licensing cost is also very low. I rate the cost and pricing a three out of ten."
"The prices are slightly expensive."
"Cloudflare Zero Trust Platform's pricing is good."
"My company has to make yearly payments towards the licensing costs attached to the solution. There are no hidden charges apart from the licensing costs of the solution."
"We were using Proofpoint and then we switched to Cisco... reportability was one of the main reasons we switched, but the biggest one was cost. If you can get an equivalent functionality for a better price it's wise to do so. That's what our primary decision came down to: We could get equivalent functionality at a lower price point."
"Licensing costs depend on how many users there are. It could range between $5 and $7 per month, per user."
"It's adapted to the market. It's similar to other vendors. We at least don't have many problems regarding that because Cisco is adaptable on that side. When we present the solutions to the customers, we tend to achieve the goals that the customer has in terms of the budget for such implementations."
"There were no other costs in addition to the standard licensing fees."
"It is an expensive product. I rate its pricing an eight or nine."
"It is a reasonably priced solution."
"I would rate the pricing a ten out of ten, where one is cheap, and ten is expensive."
"Compared to Cisco's on-prem service, the cost is the same, but you don't have to pay for the hardware and you don't have to maintain the system, as far as upgrades and hardware failures are concerned. It is cheaper to operate on their cloud service than it is to operate with their on-prem service."
"The pricing is normal. Considering its popularity, it's not overpriced."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"I was working in the government and it was too expensive for us to use our Microsoft products."
"The license is expensive because the cost is based on the number of users."
"The product is very expensive."
"It's a user-base subscription."
"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
"I know that the product is incredibly expensive."
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Top Industries

By visitors reading reviews
Comms Service Provider
10%
Computer Software Company
9%
Financial Services Firm
8%
Manufacturing Company
8%
Computer Software Company
10%
Manufacturing Company
10%
Financial Services Firm
8%
Government
6%
Computer Software Company
13%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business10
Midsize Enterprise2
Large Enterprise10
By reviewers
Company SizeCount
Small Business22
Midsize Enterprise18
Large Enterprise26
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise10
Large Enterprise31
 

Questions from the Community

What needs improvement with Cloudflare Access?
Cloudflare Access has strong integration with Microsoft, among other platforms. However, when it comes to Kaspersky, ...
What is your primary use case for Cloudflare Access?
Cloudflare Access provides secure access to internal applications for employees, external members of the organization...
What advice do you have for others considering Cloudflare Access?
Cloudflare Access is one of the best integrations available. While about two hundred vendors offer similar services, ...
What do you like most about Cisco Secure Email?
Cisco Secure Email is a budget-friendly solution.
What is your experience regarding pricing and costs for Cisco Secure Email?
The pricing structure is good as it is user-based or email client-based, which is positive for clients.
What needs improvement with Cisco Secure Email?
The areas of Cisco Secure Email that could be improved or enhanced are the slowness in the console. I don't think it ...
What needs improvement with Microsoft Defender for Office 365?
The inbuilt analysis of false positives can be faster. It's not slow, but it can be faster.
What is your primary use case for Microsoft Defender for Office 365?
My use case for Microsoft Defender for Office 365 is for email protection, safe links, protection of links, documents...
 

Also Known As

Cloudflare Area 1 Email Security, Cloudflare Bot Management, Cloudflare Gateway, Cloudflare Zero Trust Platform, Cloudflare DDoS, Cloudflare SASE & SSE Platform
Cisco Email Security, IronPort, Cisco Email Security, ESA, Email Security Appliances
MS Defender for Office 365
 

Overview

 

Sample Customers

23andMe
SUNY Old Westbury, CoxHealth, City of Fullerton, Indra
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email vs. Microsoft Defender for Office 365 and other solutions. Updated: March 2026.
884,933 professionals have used our research since 2012.