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Cisco Secure Email vs Microsoft Defender for Office 365 comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Jul 27, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
6.4
Cisco Secure Email enhances ROI with robust security, reducing disruptions and downtime from cyber threats, despite perceived high costs.
Sentiment score
7.3
Microsoft Defender for Office 365 is praised for enhancing security, reducing costs, and improving productivity with integrated threat protection.
It has also decreased our time to detection and response by about 15 to 20 percent.
Overall, cost of owning and operating our system goes down.
It's hard to quantify the return on investment we've seen from Microsoft Defender for Office 365.
 

Customer Service

Sentiment score
7.3
Cisco Secure Email support is praised for its responsiveness and expertise, though experiences can vary based on assigned engineers.
Sentiment score
6.0
Microsoft Defender for Office 365 support is mixed, praised for responsiveness but criticized for delays and outdated documentation.
Cisco's tech support can be hit or miss, depending on the engineer you get.
The support is pretty decent, with a rating of eight out of ten.
Over the past two years, there have been no critical problems.
we opened tickets, and they typically resolve them quickly.
Customer service and support have been fantastic.
 

Scalability Issues

Sentiment score
7.2
Cisco Secure Email provides scalable solutions for seamless user migration and system growth, with reliable cloud service options.
Sentiment score
8.0
Microsoft Defender for Office 365 seamlessly scales for global users, enabling effective cybersecurity with adaptable cloud-based capabilities and careful planning.
The on-premises hardware is not very scalable, but switching to the SaaS offering is expected to improve scalability.
We have never faced scalability problems, and Microsoft manages it effectively.
Microsoft Defender for Office 365 scales transparently for us, as we grew from 1,000 users to 3,000 users, and we didn't notice much difference.
 

Stability Issues

Sentiment score
8.0
Cisco Secure Email is praised for reliability, consistent performance, easy maintenance, and high user satisfaction with stable uptime.
Sentiment score
7.5
Microsoft Defender for Office 365 is praised for its stability, reliability, operational effectiveness, and high user satisfaction despite minor issues.
Based on my experience, the stability of Cisco Secure Email is very strong.
The solution is stable, as we have been using it for the past two years.
I would assess the stability and reliability of Microsoft Defender for Office 365 as very stable, with barely any issues.
Overall, the stability and reliability of Microsoft Defender for Office 365 are good.
 

Room For Improvement

Cisco Secure Email's high cost, complexity, poor interface, and limited integration impact usability, requiring AI and service enhancements.
Microsoft Defender for Office 365 needs better virus blocking, integration, threat detection, user-friendly configuration, and competitive pricing improvements.
The solution should better analyze the actual content rather than only focusing on the email header or origin.
It would be beneficial to have the functionality of the Email Threat Defense integrated into the Email Security Gateway so customers don't have to buy two products for full email protection.
The main area for improvement is simplifying the implementation and rollout process.
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published.
There is a different console for different things; I just want one consolidated console.
 

Setup Cost

Cisco Secure Email is priced higher, but users find its extensive features and security benefits justify the cost.
Microsoft Defender for Office 365 offers comprehensive security, valued for integration with E3/E5 licenses, despite varied perceptions on cost.
Its cost is bundled with other Cisco products.
The licensing is a mess and needs sorting out.
The pricing structure is good as it is user-based or email client-based, which is positive for clients.
We've likely saved 30% of costs.
Money-wise, it is a part of the Office 365 suite, making it slightly more expensive compared to Trend Micro.
Microsoft is quite affordable with a lot of features available for any size organization.
 

Valuable Features

Cisco Secure Email provides comprehensive threat management with advanced filtering, intuitive management, and seamless integration, enhancing email security effectively.
Microsoft Defender for Office 365 provides comprehensive security features, enhancing protection and efficiency across platforms with real-time threat detection.
It also possesses multiple modules for spam detection, malware detection, and threat intelligence, which are valuable in categorizing emails and determining actions.
It is highly effective in catching phishing and spam emails.
It covers everything through email, like antivirus, IDS, and IPS.
It ranks the threats and allows us to prioritize those hitting us the hardest, such as email threats.
It provides end-to-end visibility on email threats such as phishing, extending beyond Exchange Online Protection.
The value of the DLP feature is significant to us because we have internal data, sometimes sensitive, and the users may not always be aware of security and privacy, which might lead them to send out information mistakenly to external parties.
 

Categories and Ranking

Cisco Secure Email
Ranking in Email Security
5th
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
62
Ranking in other categories
Cisco Security Portfolio (7th)
Microsoft Defender for Offi...
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
53
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
 

Mindshare comparison

As of August 2025, in the Email Security category, the mindshare of Cisco Secure Email is 6.1%, down from 8.2% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 12.1%, down from 16.1% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security
 

Featured Reviews

Kostas Karidas - PeerSpot reviewer
Helps prevent security breaches but fails to improve in the area of AI
I have not noticed any impressive advanced threat protection mechanisms in the tool. I don't know if there are any AI features in the product. I don't know if there is any other technology embedded in the solution. Cisco Secure Email successfully mitigated potential email threats. My company has seen plenty of scenarios where Cisco Secure Email successfully mitigated potential email threats, spam emails, and fraudulent domains. The product is good for dealing with spam emails, and it can take care of more than 100 spam emails per day. A huge number of spam emails are monitored with the help of Cisco Secure Email. I would not recommend the product to other businesses because you need to have some kind of expertise in configuring and knowing a bit about the tool's GUI. The tool also lacks in the area of AI mechanics. If I would like to have an overview and review another solution, I would go for another product other than Cisco Secure Email. I can definitely suggest others to look at the product and review it, but I would also recommend that they compare it with the other solutions in the market. I wouldn't prioritize Cisco Secure Email over other tools. Either the support partner of the product or I take care of the tool's maintenance phase by looking into the configurations and doing some fine-tuning. I rate the tool a seven to eight out of ten.
Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
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Top Industries

By visitors reading reviews
Computer Software Company
20%
Financial Services Firm
9%
Manufacturing Company
7%
Government
6%
Computer Software Company
16%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Cisco Secure Email?
Cisco Secure Email is a budget-friendly solution.
What is your experience regarding pricing and costs for Cisco Secure Email?
The pricing structure is good as it is user-based or email client-based, which is positive for clients.
What needs improvement with Cisco Secure Email?
The user interface of the Email Security Gateway ( /products/security-gateway-reviews ) should be improved. It would be beneficial to have the functionality of the Email Threat Defense integrated i...
What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published. It's essential to enhan...
 

Also Known As

Cisco Email Security, IronPort, Cisco Email Security, ESA, Email Security Appliances
MS Defender for Office 365
 

Overview

 

Sample Customers

SUNY Old Westbury, CoxHealth, City of Fullerton, Indra
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email vs. Microsoft Defender for Office 365 and other solutions. Updated: July 2025.
865,295 professionals have used our research since 2012.