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Microsoft Defender for Office 365 vs Trellix Advanced Threat Defense comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (1st), Email Security (2nd), Microsoft Security Suite (8th), Secure Email Gateway (SEG) (1st)
Trellix Advanced Threat Def...
Ranking in Advanced Threat Protection (ATP)
23rd
Average Rating
7.8
Reviews Sentiment
5.6
Number of Reviews
9
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of May 2026, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 6.7%, down from 14.9% compared to the previous year. The mindshare of Trellix Advanced Threat Defense is 2.1%, up from 1.3% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3656.7%
Trellix Advanced Threat Defense2.1%
Other91.2%
Advanced Threat Protection (ATP)
 

Featured Reviews

Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.
PP
RSSI at SDIS49
Ensuring long-term reliability while seeking internal email management enhancements
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it's a cloud product, so we don't really know the version as it's always updated. We have not had any problem, but it's difficult to report on what's going on because some days they can wash out perhaps 100 mails, and then it's difficult to say how many attacks you have reached. The right email has been washed out and then nobody has complained. We do not use the Threat Visualization feature; as we are in MX, the mail is washed out before it is in the mail inbox of the user, thus avoiding any problem requiring a reservation. In fact, there is no integration with existing security frameworks. The only problem we can have is that as we have no API interface, there is no inspection of internal mail. I rate Trellix Advanced Threat Defense a nine out of ten.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"It has significantly decreased my time to detection and response."
"Safe attachments, safe links, policies, and the ability to protect from zero-day threats are the most valuable features."
"The two main features that prove most beneficial for us are URL scanning and attachment scanning."
"The product's scalability is good."
"Microsoft Defender for Office 365 has improved my organization's security. It makes it easier to manage the infrastructure without the help of third-party applications."
"The stability of Microsoft Defender for Office 365 is fantastic."
"The most valuable feature is the integration. It's a single console, so we don't have to switch around between multiple products. Another valuable feature is the ease of operations and maintenance."
"The insights provided with Microsoft Defender for Office 365 are helpful because it comes with the E5 license, and by default, we can use a lot of capabilities."
"I recommend this solution because of its ease of use."
"It was easy to set up initially."
"The features I find most valuable are: the management, the ability for automatic remediation of threats and it can successfully detect a threat, and to act upon it."
"If a system admin can put in the patience to read and constantly update the ePO system in terms of rules, enforcing them at regular intervals, you can safely go to sleep every night."
"I see ROI, as it stops in excess of twenty-five malware events per month, all of which could be critical to the business."
"It is stable and reliable."
"Provides good exfiltration, and is an all-in-one product."
"Its greatest strength is the DXL client which can rapidly disseminate attack information to all clients via the McAfee Agent instead of going through the ePO server."
 

Cons

"We noticed that from time to time, Microsoft's stability does have problems. Sometimes the service goes up and down. Sometimes they change without prior notice."
"About eight months ago, we started to measure the quantity of phishing and spam that we have been receiving, and it has been increasing a lot. That means that protection for our email is not as good as we were expecting."
"Microsoft should provide more documentation for users so they can self-educate. I would like to see more documentation for advanced security features."
"Microsoft sometimes has downtime, and we'll get several incidents coming in back to back. We have a huge backlog of notifications, many of which may be false positives. However, there might be serious alerts, so we can't risk dismissing all of them at once."
"The custom alerts have to improve a lot."
"The visibility into threats is not up to the mark, as I do not have control. I rate my experience with Microsoft Defender for Office 365 as six out of ten due to troubleshooting and pricing concerns."
"Configuration requires going to a lot of places rather than just accessing one tab."
"It is not up to the mark in comparison with Wiz or Palo Alto."
"Make the ATD system a part of the whole product and take the whole thing onto the cloud. While it is there already, it is not to the same level as the on-premise version."
"The support on their side is not readily available. It takes a while."
"Some of our customers have mentioned the lack of a tool that would allow for remote capabilities without being attached to the internet."
"We'd like them to be better at dealing with script threats."
"This product does the job, but it is not flexible enough to do new environments yet."
"The initial setup was industry standard complex. It takes awhile and has a lot of planning involved. It could be simplified with product redesign."
"I would like to see future versions of the solution incorporate artificial intelligence technology."
"There could be a tool that automatically updates all-new Microsoft IPs, which are available for free to connect to the client."
 

Pricing and Cost Advice

"I was working in the government and it was too expensive for us to use our Microsoft products."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
"The pricing is normal. Considering its popularity, it's not overpriced."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
"It's a user-base subscription."
"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"The product is expensive, but it is better than the rest of them in the industry."
"Our licensing fees for this solution are approximately one million dollars per year."
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Top Industries

By visitors reading reviews
Computer Software Company
12%
Financial Services Firm
9%
Manufacturing Company
8%
Comms Service Provider
7%
Construction Company
16%
Comms Service Provider
12%
Outsourcing Company
11%
Financial Services Firm
9%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
By reviewers
Company SizeCount
Small Business3
Midsize Enterprise4
Large Enterprise5
 

Questions from the Community

What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as a standalone product. It's very competitive compared to what competitors are ch...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware. We are seeing a lot more malware-less emails that Defender for Offi...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
What needs improvement with McAfee Advanced Threat Defense?
I would like to see an API interface for internal email and control of outgoing email to make it closer to 10. It's necessary; today we have an MX interface, and it would be interesting to have an ...
What is your primary use case for McAfee Advanced Threat Defense?
We are working with Palo Alto products, specifically firewalls. We are only using Palo Alto Firewalls and not Cortex. With FireEye and Trellix, we only work with ETP now because the NDR function wh...
What advice do you have for others considering McAfee Advanced Threat Defense?
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it'...
 

Also Known As

MS Defender for Office 365
McAfee Advanced Threat Defense
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
The Radicati Group, Florida International University, MGM Resorts International, County Durham andDarlington NHS Foundation Trust
Find out what your peers are saying about Microsoft Defender for Office 365 vs. Trellix Advanced Threat Defense and other solutions. Updated: April 2026.
893,311 professionals have used our research since 2012.