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Microsoft Defender for Office 365 vs Trellix Advanced Threat Defense comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
60
Ranking in other categories
Email Archiving (1st), Email Security (1st), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Trellix Advanced Threat Def...
Ranking in Advanced Threat Protection (ATP)
22nd
Average Rating
7.8
Reviews Sentiment
5.6
Number of Reviews
9
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of January 2026, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 9.7%, down from 16.8% compared to the previous year. The mindshare of Trellix Advanced Threat Defense is 1.9%, up from 1.0% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
Microsoft Defender for Office 3659.7%
Trellix Advanced Threat Defense1.9%
Other88.4%
Advanced Threat Protection (ATP)
 

Featured Reviews

Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.
PP
RSSI at SDIS49
Ensuring long-term reliability while seeking internal email management enhancements
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it's a cloud product, so we don't really know the version as it's always updated. We have not had any problem, but it's difficult to report on what's going on because some days they can wash out perhaps 100 mails, and then it's difficult to say how many attacks you have reached. The right email has been washed out and then nobody has complained. We do not use the Threat Visualization feature; as we are in MX, the mail is washed out before it is in the mail inbox of the user, thus avoiding any problem requiring a reservation. In fact, there is no integration with existing security frameworks. The only problem we can have is that as we have no API interface, there is no inspection of internal mail. I rate Trellix Advanced Threat Defense a nine out of ten.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The email protection is excellent, especially in terms of anti-phishing policies."
"The most valuable feature of Microsoft Defender for Office 365 is its spam filter."
"Since we have started using the solution, there have been fewer compromises."
"I like its investigation capabilities, as that is what is most important to me. It is fairly simple with a user-friendly interface."
"It also gives the vulnerability status according to the versions you have selected. Let's say you have Google Chrome. It mentions the versions it has, and it updates. Within two hours of an update, it is reflected in the dashboard. That's really nice to have."
"Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the individuals within our organization who are affected."
"It also gives me good visibility because, with Defender, I'm using a Microsoft product to defend Microsoft products. The integration was really seamless and I have wide visibility because it picks up almost everything. Literally, I can see almost every activity that happens, from the e-mail to the workstation itself."
"There are several features that I consider valuable."
"The fact that in 10 years, we have had no problem is the most valuable feature for us; it's really a washing machine, but the only problem we face is that it's difficult to report on this product."
"Its greatest strength is the DXL client which can rapidly disseminate attack information to all clients via the McAfee Agent instead of going through the ePO server."
"The most valuable features are the administration console and its detection and response module."
"It stops in excess of twenty-five malware events per month, all of which could be critical to the business."
"Provides good exfiltration, and is an all-in-one product."
"It is stable and reliable."
"I recommend this solution because of its ease of use."
"It is very scalable."
 

Cons

"Sometimes I have to recategorize things when it takes the wrong step and I do not want it to classify something as suspicious."
"Microsoft sometimes has downtime, and we'll get several incidents coming in back to back. We have a huge backlog of notifications, many of which may be false positives. However, there might be serious alerts, so we can't risk dismissing all of them at once."
"Microsoft Defender for Office 365 must improve the overall management style, including the GUI. It also needs to change the filters so that it is easy to whitelist and blacklist data."
"Microsoft Defender for Office 365's Mac functionality requires improvement to deliver the same level of protection found on Windows devices."
"This product's effectiveness could be improved, in terms of detecting unwanted spam or even malware between the emails, compared to other products."
"The visibility for the weaknesses in the system and unauthorized access can be improved."
"We still see many false positives from time to time with Microsoft Defender for Office 365, so it would be good if we can reduce those false positives and provide better workflows for our end users, as sometimes they may not know what to do when they encounter a false positive."
"I'd like some additional features any product can give me to protect our environment in a better way."
"The only problem we can have is that as we have no API interface, there is no inspection of internal mail."
"The initial setup was industry standard complex. It takes awhile and has a lot of planning involved. It could be simplified with product redesign."
"We'd like them to be better at dealing with script threats."
"Make the ATD system a part of the whole product and take the whole thing onto the cloud. While it is there already, it is not to the same level as the on-premise version."
"Lacks remote capabilities not dependent on the internet."
"This solution needs to be made "cloud ready"."
"There could be a tool that automatically updates all-new Microsoft IPs, which are available for free to connect to the client."
"I would like to see future versions of the solution incorporate artificial intelligence technology."
 

Pricing and Cost Advice

"I know that the product is incredibly expensive."
"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"It's a user-base subscription."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"The product is expensive, but it is better than the rest of them in the industry."
"Our licensing fees for this solution are approximately one million dollars per year."
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Top Industries

By visitors reading reviews
Computer Software Company
14%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
Government
15%
Comms Service Provider
13%
Performing Arts
11%
University
10%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business23
Midsize Enterprise10
Large Enterprise31
By reviewers
Company SizeCount
Small Business3
Midsize Enterprise4
Large Enterprise5
 

Questions from the Community

What needs improvement with Microsoft Defender for Office 365?
The inbuilt analysis of false positives can be faster. It's not slow, but it can be faster.
What is your primary use case for Microsoft Defender for Office 365?
My use case for Microsoft Defender for Office 365 is for email protection, safe links, protection of links, documents, protecting my documents, and protecting attachments. I also use it to conduct ...
What do you like most about McAfee Advanced Threat Defense?
I recommend this solution because of its ease of use.
What needs improvement with McAfee Advanced Threat Defense?
I would like to see an API interface for internal email and control of outgoing email to make it closer to 10. It's necessary; today we have an MX interface, and it would be interesting to have an ...
What is your primary use case for McAfee Advanced Threat Defense?
We are working with Palo Alto products, specifically firewalls. We are only using Palo Alto Firewalls and not Cortex. With FireEye and Trellix, we only work with ETP now because the NDR function wh...
 

Also Known As

MS Defender for Office 365
McAfee Advanced Threat Defense
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
The Radicati Group, Florida International University, MGM Resorts International, County Durham andDarlington NHS Foundation Trust
Find out what your peers are saying about Microsoft Defender for Office 365 vs. Trellix Advanced Threat Defense and other solutions. Updated: December 2025.
881,082 professionals have used our research since 2012.