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ThreatLocker Zero Trust Platform vs Trellix Advanced Threat Defense comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Mar 17, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

ThreatLocker Zero Trust Pla...
Ranking in Advanced Threat Protection (ATP)
4th
Average Rating
9.2
Reviews Sentiment
7.1
Number of Reviews
107
Ranking in other categories
Network Access Control (NAC) (4th), Endpoint Protection Platform (EPP) (5th), Application Control (1st), ZTNA as a Service (5th), ZTNA (4th), Ransomware Protection (1st)
Trellix Advanced Threat Def...
Ranking in Advanced Threat Protection (ATP)
21st
Average Rating
7.8
Reviews Sentiment
5.6
Number of Reviews
9
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of November 2026, in the Advanced Threat Protection (ATP) category, the mindshare of ThreatLocker Zero Trust Platform is 2.8%, up from 2.5% compared to the previous year. The mindshare of Trellix Advanced Threat Defense is 2.1%, up from 1.6% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Mindshare Distribution
ProductMindshare (%)
ThreatLocker Zero Trust Platform2.8%
Trellix Advanced Threat Defense2.1%
Other95.1%
Advanced Threat Protection (ATP)
 

Featured Reviews

Santo Joy - PeerSpot reviewer
Head Of Cyber Security at a outsourcing company with 201-500 employees
Security controls have been strengthened with granular application, ringfencing, and access policies
The features of ThreatLocker Zero Trust Endpoint Protection Platform that I like the most are the Ringfencing, elevation control, storage control, and application whitelisting functionality. For examples of how these features benefit my company, we were looking for a solution across various vendors to actually implement application whitelisting controls. ThreatLocker's agent, which is very lightweight and does not use much CPU or RAM, helped us achieve that solution. Ringfencing was an add-on that ticked off a lot of Australian framework security controls, which is the reason we chose it. My impression of the allowlisting feature in terms of managing which software, scripts, and libraries run on my devices is that ThreatLocker's community page has a lot of information around this, which is very helpful. Not only that, the Cyber Hero support that ThreatLocker provides gives us insights and best practices, helping us achieve that solution and guiding us to the right platform. The impact of Ringfencing on controlling the behavior of approved applications has been a big winner for us because it is something that many other platforms do not provide as a functionality. Having that allowed us to identify what applications talk to each other, which is something that many other platforms do not do. The network control feature impacts my ability to manage network traffic across my endpoints and servers. We have not used this widely across all our partners, but wherever required, we use it. It has been an easy solution for those customers to get that control implemented. The elevation feature's role in facilitating just-in-time administrative access for approved applications shows that elevation control helps in many use cases involving remote control platforms, door usage, and security system platforms that require local admins. There are many solutions that provide this functionality, but the licensing cost seems to be expensive, and it also adds another solution into the mix. Rather than doing that, we try to use ThreatLocker Zero Trust Endpoint Protection Platform to achieve that control. Regarding the storage control feature, I have used it. The primary function is USB blocking, which is very widely adopted, and also just locking down and allowing certain users to access certain file locations helps us there. When it comes to enforcing policy-driven access over various storage devices, it depends on the business risk adapted by the companies that we support, but generally the use case is USB and external storage devices where companies know that is a risk, but they do not have appropriate solutions. There are EDR platforms that claim to do this, but ThreatLocker Zero Trust Endpoint Protection Platform does it at an advanced level. My assessment of the efficiency of the real-time threat intelligence and category controls employed by Web Control in blocking malicious and non-compliant sites leads me to think that Web Control is another functionality within ThreatLocker Zero Trust Endpoint Protection Platform that is an add-on on top of the current set. That is another solution that we use based on what is required for the company, but again, that is not widely adapted yet for our partners.
PP
RSSI at SDIS49
Ensuring long-term reliability while seeking internal email management enhancements
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it's a cloud product, so we don't really know the version as it's always updated. We have not had any problem, but it's difficult to report on what's going on because some days they can wash out perhaps 100 mails, and then it's difficult to say how many attacks you have reached. The right email has been washed out and then nobody has complained. We do not use the Threat Visualization feature; as we are in MX, the mail is washed out before it is in the mail inbox of the user, thus avoiding any problem requiring a reservation. In fact, there is no integration with existing security frameworks. The only problem we can have is that as we have no API interface, there is no inspection of internal mail. I rate Trellix Advanced Threat Defense a nine out of ten.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The time saved from dealing with ransomware nonsense is invaluable."
"ThreatLocker Zero Trust Platform has really helped us identify and secure the highly sensitive information and keep everything together at one place."
"ThreatLocker Zero Trust Platform has impacted our organization positively by providing protection and it has been a great tool for us from a security perspective."
"ThreatLocker Zero Trust Platform has had a positive impact on my organization by greatly increasing the level of security and very quickly increasing control over which applications and software can be used within the organization, making it much more efficient in an agile way."
"The control list is the best feature. For our company, it provides value to our customers since they can see we are improving our security."
"I would evaluate the customer service and technical support from ThreatLocker as phenomenal; it's white glove service, better than any other security product we've owned."
"The environment with ThreatLocker always blocked suspicious activity and anything that was not added to the whitelist, proving to be a very secure tool."
"ThreatLocker Zero Trust Endpoint Protection Platform has absolutely helped my company save on operational costs and expenses."
"The most valuable features are the administration console and its detection and response module."
"Its greatest strength is the DXL client which can rapidly disseminate attack information to all clients via the McAfee Agent instead of going through the ePO server."
"I see ROI, as it stops in excess of twenty-five malware events per month, all of which could be critical to the business."
"Provides good exfiltration, and is an all-in-one product."
"It was easy to set up initially."
"The product is expensive, but it is better than the rest of them in the industry."
"It is stable and reliable."
"It is very scalable."
 

Cons

"The Cyber Hero certification exam could use a bit of love, but overall, I have been very satisfied with the platform."
"The support could be quicker. There are times when there is a delay in getting a response. This is problematic when immediate attention is needed."
"I have not seen a return on investment yet, but there is a small amount of time saved because of fewer dashboards."
"The complaints are that users think the new features are quite rigid for them."
"Regarding ThreatLocker Zero Trust Platform's AI capabilities, I would say its accuracy and reliability of output is about fifty to fifty."
"ThreatLocker University offers many good training modules, but more in-depth training for advanced platforms would be beneficial."
"The biggest thing I would like to see improved in ThreatLocker Zero Trust Endpoint Protection Platform is reporting."
"From a reporting perspective, enhancing the ability to customize reports would be beneficial."
"The support on their side is not readily available. It takes a while."
"It was not complex, but there are things to look out for, because it's an intense product. It scans intensely and there are major obstacles to overcome if it scans while users are using a network, then it is not a good thing."
"Make the ATD appliance a part of the whole product offering and take the whole thing onto the cloud."
"The only problem we can have is that as we have no API interface, there is no inspection of internal mail."
"Lacks remote capabilities not dependent on the internet."
"We'd like them to be better at dealing with script threats."
"I would like to see future versions of the solution incorporate artificial intelligence technology."
"This solution needs to be made "cloud ready"."
 

Pricing and Cost Advice

"I do not deal with pricing, but I assume it is cost-effective for us. We choose a solution based on functionality and affordability."
"I do not know about the licensing and price as it comes bundled from our MSP. However, it seems fairly reasonable for us, which is why we chose it."
"Considering what this product does, ThreatLocker is very well-priced, if not too nicely priced for the customer."
"The pricing is pretty fair, considering other solutions. Licensing-wise, it did not take long."
"We have not had any real issues with the pricing. As they have added more features, due to the way our contracts are structured with our customers, we have had to hold off on adopting the new features because they do add costs."
"I believe ThreatLocker's pricing model is fair and flexible, allowing account managers to offer customized deals based on our specific needs."
"Others say ThreatLocker is too expensive, and I tell them they're dreaming. It's well-priced for what it does."
"We have encountered a few challenges regarding pricing, contract renewals, and additions. As we explored adding features like Cyber Hero, it proved to be an increased expense for our clients. This was primarily a mistake on our part due to how we initially priced it to clients."
"The product is expensive, but it is better than the rest of them in the industry."
"Our licensing fees for this solution are approximately one million dollars per year."
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Top Industries

By visitors reading reviews
Manufacturing Company
13%
Financial Services Firm
12%
Computer Software Company
9%
Outsourcing Company
9%
Construction Company
15%
Outsourcing Company
15%
Financial Services Firm
13%
Manufacturing Company
9%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business73
Midsize Enterprise21
Large Enterprise23
By reviewers
Company SizeCount
Small Business3
Midsize Enterprise4
Large Enterprise5
 

Questions from the Community

What is your experience regarding pricing and costs for ThreatLocker Allowlisting?
My experience with pricing, setup cost, and licensing with ThreatLocker Zero Trust Platform is that it is owned by my organization, so I am not certain about the pricing and licensing details. Howe...
What needs improvement with ThreatLocker Allowlisting?
I believe ThreatLocker Zero Trust Platform's marketing strategy has to be changed because only fewer organizations, such as small and mid-scale organizations, have been using it right now. It has t...
What is your primary use case for ThreatLocker Allowlisting?
My main use case for ThreatLocker Zero Trust Platform is that it helps to prevent somebody from accessing scripts. It will allow access if it is a valid one; otherwise, we can reject it. This helps...
What needs improvement with McAfee Advanced Threat Defense?
I would like to see an API interface for internal email and control of outgoing email to make it closer to 10. It's necessary; today we have an MX interface, and it would be interesting to have an ...
What is your primary use case for McAfee Advanced Threat Defense?
We are working with Palo Alto products, specifically firewalls. We are only using Palo Alto Firewalls and not Cortex. With FireEye and Trellix, we only work with ETP now because the NDR function wh...
What advice do you have for others considering McAfee Advanced Threat Defense?
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it'...
 

Also Known As

Protect, Allowlisting, Network Control, Ringfencing
McAfee Advanced Threat Defense
 

Overview

 

Sample Customers

Information Not Available
The Radicati Group, Florida International University, MGM Resorts International, County Durham andDarlington NHS Foundation Trust
Find out what your peers are saying about ThreatLocker Zero Trust Platform vs. Trellix Advanced Threat Defense and other solutions. Updated: September 2026.
920,769 professionals have used our research since 2012.