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Microsoft Defender for Office 365 vs Proofpoint Targeted Attack Protection comparison

 

Comparison Buyer's Guide

Executive Summary

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
2nd
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
53
Ranking in other categories
Email Archiving (1st), Email Security (1st), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Proofpoint Targeted Attack ...
Ranking in Advanced Threat Protection (ATP)
30th
Average Rating
7.0
Reviews Sentiment
7.1
Number of Reviews
1
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of October 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 7.7%, down from 12.1% compared to the previous year. The mindshare of Proofpoint Targeted Attack Protection is 1.7%, down from 2.3% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
Microsoft Defender for Office 3657.7%
Proofpoint Targeted Attack Protection1.7%
Other90.6%
Advanced Threat Protection (ATP)
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
KC
Dynamic runtime engine and good protection, but needs better support and a single console
We have two to three issues per month. We contact Proofpoint's customer support for these issues. I am a major point of contact for support. If I am not able to resolve an issue, we will be reaching out to them. Proofpoint can take a couple of days to get back. I also deal with other applications from Okta and Microsoft, and we get the support within a couple of hours. There is a lot of difference between a couple of hours and a couple of days. So, Proofpoint's support should be improved. Okta and Microsoft are also able to do a Zoom or video call, but Proofpoint provides support only through email communication. Only if you request, it would be a Zoom or video session.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Microsoft Defender for Office 365 helps people to work remotely. It is a secure solution. We don't need to use our company's computers or get VPN connections to the networks. I can control how they share screens and what they send to the devices. It keeps our organizations confidential and sensitive information safe."
"The deployment capability is a great feature."
"The solution is very easy to use. All you have to do is to assign the license to the end-user and it's done. The customer will only have the feature activated, and the solution will monitor the emails to determine if they are a threat or not."
"At the moment we are satisfied with this product. It's a stable, scalable, and resilient solution for us."
"Microsoft Defender has a feature to protect each and every attachment. Even if it's an encrypted attachment, it will check for any potential threats."
"Defender helps us prioritize threats across our organization."
"Safe attachments, safe links, policies, and the ability to protect from zero-day threats are the most valuable features."
"It also gives the vulnerability status according to the versions you have selected. Let's say you have Google Chrome. It mentions the versions it has, and it updates. Within two hours of an update, it is reflected in the dashboard. That's really nice to have."
"It has a dynamic runtime engine, which gives it an advantage over Prisma that has a static engine. In Prisma, we have to do additional malware analysis, which is not required in Proofpoint."
 

Cons

"One area for improvement is integration. For example, when it comes to external SaaS platforms, we were not able to get a lot of information on integrations with such apps for security and authentication."
"The custom alerts have to improve a lot."
"Specifically, within Microsoft Defender for Office 365, I want it to improve the DLP capabilities."
"It would be better if it were more scalable. It depends on the architecture, but we would like to make it more scalable for both data centers."
"The visibility into threats is not up to the mark, as I do not have control. I rate my experience with Microsoft Defender for Office 365 as six out of ten due to troubleshooting and pricing concerns."
"There is room for improvement in terms of reporting."
"Microsoft Defender for Office 365 could improve by giving customers information on techniques to prevent threats. For example, information about best practices on how to protect their own devices against hackers and scammers, such as educational information or training. This would help others have a better understanding of cyber security. Additionally, there can be more security features added."
"We need to be able to whitelist data at the backend."
"We are using the TRAP console that has a Linux-based UI, which is not user-friendly. The TAP console looks very advanced. Currently, we are maintaining three different consoles, and it is sometimes hard to switch between them or try to grab the data."
 

Pricing and Cost Advice

"The pricing has become expensive."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"The pricing is normal. Considering its popularity, it's not overpriced."
"The solution could be better by simplifying the business model of their licensing. It was hard to figure out how to get the licensing done for the environment, initially."
"The license is expensive because the cost is based on the number of users."
"I was working in the government and it was too expensive for us to use our Microsoft products."
"The product is very expensive."
Information not available
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Top Industries

By visitors reading reviews
Computer Software Company
15%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
Manufacturing Company
12%
Financial Services Firm
9%
Healthcare Company
7%
Transportation Company
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business23
Midsize Enterprise8
Large Enterprise27
No data available
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
I think that Microsoft Defender for Office 365 could be improved if it could use VirusTotal to compare the programs or anything that I download. VirusTotal helps to identify viruses, malware, troja...
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Also Known As

MS Defender for Office 365
Targeted Attack Protection
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Brinker Capital
Find out what your peers are saying about Palo Alto Networks, Microsoft, Fortinet and others in Advanced Threat Protection (ATP). Updated: September 2025.
868,787 professionals have used our research since 2012.