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Microsoft Defender for Office 365 vs Proofpoint Targeted Attack Protection comparison

 

Comparison Buyer's Guide

Executive Summary

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
2nd
Average Rating
8.4
Reviews Sentiment
7.0
Number of Reviews
52
Ranking in other categories
Email Archiving (1st), Email Security (1st), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Proofpoint Targeted Attack ...
Ranking in Advanced Threat Protection (ATP)
28th
Average Rating
7.0
Reviews Sentiment
7.1
Number of Reviews
1
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of July 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 8.4%, down from 13.8% compared to the previous year. The mindshare of Proofpoint Targeted Attack Protection is 1.8%, down from 2.4% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP)
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
KC
Dynamic runtime engine and good protection, but needs better support and a single console
We have two to three issues per month. We contact Proofpoint's customer support for these issues. I am a major point of contact for support. If I am not able to resolve an issue, we will be reaching out to them. Proofpoint can take a couple of days to get back. I also deal with other applications from Okta and Microsoft, and we get the support within a couple of hours. There is a lot of difference between a couple of hours and a couple of days. So, Proofpoint's support should be improved. Okta and Microsoft are also able to do a Zoom or video call, but Proofpoint provides support only through email communication. Only if you request, it would be a Zoom or video session.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The most valuable feature of Microsoft Defender for Office 365 is data backups that we can provide through ticket requests."
"Defender enables us to secure all 365-related activity from a single place. It gives us visibility into everything happening in Outlook, protecting us against phishing and other email-based threats. Defender helps us detect any suspicious behaviors."
"Since we have started using the solution, there have been fewer compromises."
"Overall, I would rate Microsoft Defender for Office 365 at a ten."
"Microsoft Defender for Office 365 helps people to work remotely. It is a secure solution. We don't need to use our company's computers or get VPN connections to the networks. I can control how they share screens and what they send to the devices. It keeps our organizations confidential and sensitive information safe."
"The product is not resource-intensive."
"Defender for Office 365 has helped eliminate having to look at multiple dashboards and that is the aspect I like most about it. It is simpler, effective, and convenient. The users like the process efficiency."
"Does a thorough job of examining email and URLs for malicious content."
"It has a dynamic runtime engine, which gives it an advantage over Prisma that has a static engine. In Prisma, we have to do additional malware analysis, which is not required in Proofpoint."
 

Cons

"We need a separate license and we don't know how to get the license that is required."
"In one of the reports I can get the exact place where a vulnerable file resides. But for that, I need to explicitly go into the device and check. If they could include that file part in the report, without my having to go to the device itself, that would help."
"We noticed that from time to time, Microsoft's stability does have problems. Sometimes the service goes up and down. Sometimes they change without prior notice."
"Microsoft Defender for Office 365 should improve the troubleshooting tools. It's unclear whether the device is blocked at the firewall level or at the device itself. The granularity needed for troubleshooting is currently lacking. From my perspective, Microsoft should address this issue to benefit many users who likely share the same sentiment."
"We need to be able to whitelist data at the backend."
"The only thing they should improve is the licensing model. They should stop changing it. A year ago, the five features I mentioned were included in one product. Now, three of them are bundled into one product, and you have to pay extra for the other two. I don't mind paying extra, but I don't want them to change it every year or every six months. I need to know what I'm looking at and not worry about it next year."
"The pre-sales cost calculations could be more transparent."
"The custom alerts have to improve a lot."
"We are using the TRAP console that has a Linux-based UI, which is not user-friendly. The TAP console looks very advanced. Currently, we are maintaining three different consoles, and it is sometimes hard to switch between them or try to grab the data."
 

Pricing and Cost Advice

"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"I was working in the government and it was too expensive for us to use our Microsoft products."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"It's a user-base subscription."
"The product is very expensive."
"The license is expensive because the cost is based on the number of users."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
9%
Manufacturing Company
8%
Government
6%
Financial Services Firm
14%
Manufacturing Company
11%
Computer Software Company
11%
Healthcare Company
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
No data available
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published. It's essential to enhan...
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Also Known As

MS Defender for Office 365
Targeted Attack Protection
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Brinker Capital
Find out what your peers are saying about Palo Alto Networks, Microsoft, Fortinet and others in Advanced Threat Protection (ATP). Updated: June 2025.
860,592 professionals have used our research since 2012.