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Microsoft Defender for Office 365 vs Proofpoint Targeted Attack Protection comparison

 

Comparison Buyer's Guide

Executive Summary

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
60
Ranking in other categories
Email Archiving (1st), Email Security (1st), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Proofpoint Targeted Attack ...
Ranking in Advanced Threat Protection (ATP)
34th
Average Rating
7.0
Reviews Sentiment
7.1
Number of Reviews
1
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of February 2026, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 8.3%, down from 16.2% compared to the previous year. The mindshare of Proofpoint Targeted Attack Protection is 1.3%, down from 1.4% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
Microsoft Defender for Office 3658.3%
Proofpoint Targeted Attack Protection1.3%
Other90.4%
Advanced Threat Protection (ATP)
 

Featured Reviews

Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.
KC
Information Security Specialist at Methanex Chile SpA
Dynamic runtime engine and good protection, but needs better support and a single console
We have two to three issues per month. We contact Proofpoint's customer support for these issues. I am a major point of contact for support. If I am not able to resolve an issue, we will be reaching out to them. Proofpoint can take a couple of days to get back. I also deal with other applications from Okta and Microsoft, and we get the support within a couple of hours. There is a lot of difference between a couple of hours and a couple of days. So, Proofpoint's support should be improved. Okta and Microsoft are also able to do a Zoom or video call, but Proofpoint provides support only through email communication. Only if you request, it would be a Zoom or video session.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The benefit that stands out to me is the ability for multiple individuals to collaborate simultaneously within the same document. Additionally, there is the option to save the document directly in the integrated OneDrive or SharePoint."
"Overall, I would rate Microsoft Defender for Office 365 at a ten."
"The two main features that prove most beneficial for us are URL scanning and attachment scanning."
"The feature I like the most about Microsoft Defender for Office 365 is that it typically runs in the background—you do not know it is there until you need to access it."
"Defender for Office 365 has helped eliminate having to look at multiple dashboards and that is the aspect I like most about it. It is simpler, effective, and convenient. The users like the process efficiency."
"Microsoft Defender for Office 365 saves me time; it does save a lot of time, especially with the automation."
"The features I appreciate most about Microsoft Defender for Office 365 are admin notifications for potential threats along with protecting our Microsoft apps such as Outlook from potential phishing attacks."
"Since we have started using the solution, there have been fewer compromises."
"It has a dynamic runtime engine, which gives it an advantage over Prisma that has a static engine. In Prisma, we have to do additional malware analysis, which is not required in Proofpoint."
 

Cons

"The custom alerts have to improve a lot."
"Microsoft wants its well-paying customers to finish testing some of its half-baked products, find bugs, and report bugs back to Microsoft's team, which is a little frustrating for those who have to manage it and roll it up to thousands of people across the organization."
"Specifically, within Microsoft Defender for Office 365, I want it to improve the DLP capabilities."
"Microsoft Defender for Office 365 must improve the overall management style, including the GUI. It also needs to change the filters so that it is easy to whitelist and blacklist data."
"There needs to be an improvement in integrating the product to work across multiple operating systems, and to have better support for non-Microsoft file types."
"The certification training for Defender for 365 needs to be deeper and incorporate Sentinel. I took all the security courses except one, and Sentinel isn't included."
"Several simulation options are available within 365, and the phishing simulation could be better."
"There is room for improvement in terms of reporting."
"We are using the TRAP console that has a Linux-based UI, which is not user-friendly. The TAP console looks very advanced. Currently, we are maintaining three different consoles, and it is sometimes hard to switch between them or try to grab the data."
 

Pricing and Cost Advice

"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"The product is expensive."
"The product is very expensive."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
Information not available
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Top Industries

By visitors reading reviews
Computer Software Company
13%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
No data available
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business23
Midsize Enterprise10
Large Enterprise31
No data available
 

Questions from the Community

What needs improvement with Microsoft Defender for Office 365?
The inbuilt analysis of false positives can be faster. It's not slow, but it can be faster.
What is your primary use case for Microsoft Defender for Office 365?
My use case for Microsoft Defender for Office 365 is for email protection, safe links, protection of links, documents, protecting my documents, and protecting attachments. I also use it to conduct ...
Ask a question
Earn 20 points
 

Also Known As

MS Defender for Office 365
Targeted Attack Protection
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Brinker Capital
Find out what your peers are saying about Palo Alto Networks, Microsoft, Proofpoint and others in Advanced Threat Protection (ATP). Updated: January 2026.
881,733 professionals have used our research since 2012.