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Cisco Secure Email Threat Defense vs Microsoft Exchange Online Protection (EOP) comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
22nd
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Exchange Online P...
Ranking in Email Security
7th
Average Rating
8.2
Reviews Sentiment
6.6
Number of Reviews
42
Ranking in other categories
Anti-Malware Tools (12th)
 

Mindshare comparison

As of February 2026, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Microsoft Exchange Online Protection (EOP) is 4.3%, down from 7.3% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Market Share Distribution
ProductMarket Share (%)
Microsoft Exchange Online Protection (EOP)4.3%
Cisco Secure Email Threat Defense1.1%
Other94.6%
Email Security
 

Featured Reviews

reviewer2541525 - PeerSpot reviewer
Principal Cyber Prevent and Defense Engineer at a comms service provider with 1,001-5,000 employees
Clawback feature performs well but analytics and integration capabilities need improvement
The integration capability with other threat intelligence platforms is not optimal, as I have experienced difficulty in sending logs to our SIEM. Cisco Secure Email Threat Defense's flexibility could be enhanced while it mostly integrates with cloud solutions, but not on-premise. The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious. Regarding room for improvement, the significant number of false positives should be addressed. The solution does not adapt to behavioral analytics and does not make changes when it sees a pattern.
NancyHartman - PeerSpot reviewer
Business Process Manager/ Educational Technologist at a educational organization with 1,001-5,000 employees
Layered email security has protected sensitive research and still flags phishing in real time
The valuable features of Microsoft Exchange Online Protection (EOP) include providing an additional layer of protection, as it builds on the basic Exchange level of security that allows us to get our work done. Another feature I appreciate is the ability to question things, as our Exchange server allows us to identify in real-time if an email is a phishing email or spam email. It really helps us identify risks, especially through our external exchanges via email or through our cloud-based platforms. Our Exchange system blocks any embedded AI from all our applications and products, so we cannot use embedded AI in our daily work from our official laptops because we have secure information. The system is quite locked down.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Regarding stability, Cisco Secure Email Threat Defense is very stable."
"The product offers protection, email security, anti-spam, and antivirus."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"Secure Email Threat Defense's scalability is good."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"On ease of use, it rates very high. It's something that I was able to get into without really looking at any documentation. I wanted to see what it felt like before I started looking at any documentation on how to use it, and it was very easy to use. It works very smoothly. The user experience is very intuitive. They did an amazing job on that."
"The advanced threat analytics and URL filtering in threat detection are good features that are working well."
"I highly recommend it as one of the best choices."
"The solution uses artificial intelligence and machine learning, so you don't need train it to detect something. The detection and response times are short. It's an excellent product."
"It's all running in the backend, so it doesn't affect the app functionality."
"Microsoft Exchange Online Protection (EOP) is used essentially for email filtering, acting as an anti-spam and security product for email."
"The threat management feature includes policies and alerts that are valuable."
"The initial setup of Microsoft Exchange Online Protection was easy."
"The security features provided by Microsoft are robust."
"The initial setup was easy. The configuration process is very straightforward."
"It is easy to configure, easy to use, easy to add exclusions, easy to track, and easy to add anything else if you want."
 

Cons

"The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious."
"This solution could be improved by integration with Sandbox."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"The physical appliance has been discontinued, although the platform still exists."
"The pricing could always be better."
"The learning curve shows that in the beginning, there are numerous false positives. For one month, we had to reclassify the false positives manually until the system learned."
"The tool is not 100% stable."
"Microsoft has some training portals, but more could be developed."
"Some features, like encryption, are not available."
"It wasn't easy or intuitive enough for me to start using it. So, the reason was that the solution changed."
"Microsoft 365 Defender and EOP policies are stable with the proper license. However, with the basic policy, it's hard to say it's stable due to configuration limitations."
"The biggest issue that I experience is that Microsoft keeps moving things around, and it's very inconsistent as to where you find the information when you're trying to work on different pieces."
"The solution lacks to elaborate on its spam policies."
"When you're using a Microsoft product solution, you can scale it, but if you're not, there are limitations."
 

Pricing and Cost Advice

"The feedback from vendors and customer is that it is expensive."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"It is expensive compared to other vendors."
"The solution’s pricing is manageable."
"Online Protection is fairly expensive."
"Regarding the price, it's comparable to other service providers. We've also looked at Check Point's offerings, and the pricing doesn't seem to be an issue."
"The product is bundled with Microsoft 365."
"The price of Microsoft Exchange Online Protection is reasonable."
"The solution's pricing is subscription-based rather than a yearly licensing cost. Pricing is based on the size of the environment and company and can be expensive."
"The tool's pricing is excellent."
"The solution is expensive but is backed by Microsoft's reputation."
"It is a low-price solution."
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Top Industries

By visitors reading reviews
Computer Software Company
12%
Marketing Services Firm
11%
Manufacturing Company
8%
Healthcare Company
7%
Computer Software Company
11%
Financial Services Firm
10%
Manufacturing Company
9%
Government
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise7
Large Enterprise11
 

Questions from the Community

What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, I am not very aware of the pricing details.
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, ar...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat Defense.
What do you like most about Microsoft Exchange Online Protection?
The initial setup was easy. The configuration process is very straightforward.
What needs improvement with Microsoft Exchange Online Protection?
From an end-user point of view, I am quite happy with Microsoft Exchange Online Protection (EOP) because my favorite feature is the ease with which I can identify if an email is a phishing email or...
What is your primary use case for Microsoft Exchange Online Protection?
Microsoft Exchange Online Protection (EOP) serves as the main use case for my company because, as a research company, we require a very high level of security. We use multiple authentication method...
 

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
Microsoft EOP, MS Exchange Online Protection
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
Information Not Available
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Exchange Online Protection (EOP) and other solutions. Updated: February 2026.
881,757 professionals have used our research since 2012.