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Cisco Secure Email Threat Defense vs Microsoft Exchange Online Protection (EOP) comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Sponsored
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
7.0
Number of Reviews
52
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Cisco Secure Email Threat D...
Ranking in Email Security
25th
Average Rating
8.0
Reviews Sentiment
7.1
Number of Reviews
14
Ranking in other categories
No ranking in other categories
Microsoft Exchange Online P...
Ranking in Email Security
6th
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
39
Ranking in other categories
Anti-Malware Tools (7th)
 

Mindshare comparison

As of July 2025, in the Email Security category, the mindshare of Microsoft Defender for Office 365 is 12.3%, down from 16.9% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Microsoft Exchange Online Protection (EOP) is 6.3%, down from 8.8% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
Enrique-Diaz Jolly - PeerSpot reviewer
Provides comprehensive threat protection with suggestions for modernizing controls
I use the email gateway as the core of the email exchange between the Internet and our domain. The email gateway serves as the email exchanger The product offers protection, email security, anti-spam, and antivirus. It includes threat intelligence with advanced malware protection and many…
Amber Worth - PeerSpot reviewer
Retrieves data from quarantines and easy to read logs with robust security features
Some of the searchability when looking for specifics in Exchange logs is tedious. Although eventually the information is located, it can be difficult if detailed information is lacking. Improving the search process by allowing searches with different types of parameters and facilitating searches within emails would be advantageous. Simplifying interfaces would also be appreciated.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Defender is a SaaS platform, so it offers more flexibility. Managing the permissions is easier. The solution's automated detection and response features are scalable."
"The ability to respond to threats if very important."
"Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the individuals within our organization who are affected."
"Overall, I would rate Microsoft Defender for Office 365 at a ten."
"The deployment capability is a great feature."
"My experience with customer support and technical support for Microsoft Defender for Office 365 has been excellent."
"Microsoft Defender for Office 365 facilitates efficient management and updates through the cloud. We do not have to worry about incompatibilities. It just works."
"The most valuable feature is the integration. It's a single console, so we don't have to switch around between multiple products. Another valuable feature is the ease of operations and maintenance."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"The product offers protection, email security, anti-spam, and antivirus."
"This solution is easy to use."
"Regarding stability, Cisco Secure Email Threat Defense is very stable."
"The features and functionalities are much better than Microsoft's in-built Defender plan."
"Secure Email Threat Defense's scalability is good."
"On ease of use, it rates very high. It's something that I was able to get into without really looking at any documentation. I wanted to see what it felt like before I started looking at any documentation on how to use it, and it was very easy to use. It works very smoothly. The user experience is very intuitive. They did an amazing job on that."
"I highly recommend it as one of the best choices."
"Microsoft Exchange Online Protection (EOP) is used essentially for email filtering, acting as an anti-spam and security product for email."
"It is scalable."
"Microsoft Exchange Online Protection has features like DLP (data loss protection), Safe Attachment, and Safe Links."
"The scalability is pretty good; it does what it is supposed to do."
"I rate Microsoft Exchange Online Protection (EOP) nine out of ten."
"The most valuable feature of Microsoft Exchange Online Protection is the accidental release of information protection capabilities. Additionally, the solution is easy to use."
"It is an easy solution."
"The solution's stability is very, very good. I didn't face any problems in the last year."
 

Cons

"Microsoft Defender for Office 365 could improve by giving customers information on techniques to prevent threats. For example, information about best practices on how to protect their own devices against hackers and scammers, such as educational information or training. This would help others have a better understanding of cyber security. Additionally, there can be more security features added."
"You should be able to deploy Defender for every subscription without the need to add servers."
"It would be better if it were more scalable. It depends on the architecture, but we would like to make it more scalable for both data centers."
"There's room for improvement regarding the time frame for retrieving emails."
"We need a separate license and we don't know how to get the license that is required."
"In one of the reports I can get the exact place where a vulnerable file resides. But for that, I need to explicitly go into the device and check. If they could include that file part in the report, without my having to go to the device itself, that would help."
"The GUI is sometimes slow to fetch the device report and could be improved."
"One area for improvement is support, in terms of being able to reach them and, especially, technical support for configuration."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"The solution is a bit expensive."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"This solution could be improved by integration with Sandbox."
"The pricing could always be better."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"Some of the searchability when looking for specifics in Exchange logs is tedious."
"The solution lacks to elaborate on its spam policies."
"Performance and speed should continue to be improved."
"If a company wants to put in line back-to-back anti-spam solutions, they need to work on that part because Microsoft recommends either you use EOP as a front line or you don't use it."
"Our company faces difficulty with Microsoft Exchange Online Protection (EOP) because it's too big, clunky, and difficult for a small client to implement quickly and easily."
"The solution needs to improve its backup."
"The solution can be complex at times. It would be nice to have the on-server version. It needs to improve the stability as well."
"The tool is not 100% stable."
 

Pricing and Cost Advice

"It's a user-base subscription."
"I know that the product is incredibly expensive."
"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"The product is expensive."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
"The feedback from vendors and customer is that it is expensive."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"It is expensive compared to other vendors."
"The solution’s pricing is manageable."
"Regarding the price, it's comparable to other service providers. We've also looked at Check Point's offerings, and the pricing doesn't seem to be an issue."
"The solution falls on the higher or more expensive side of the spectrum."
"The solution is expensive but is backed by Microsoft's reputation."
"The product's pricing is competitive for the US market."
"It is a low-price solution."
"The product is bundled with Microsoft 365."
"The solution is priced high and could be less expensive compared to other solutions."
"The price could be lower."
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
9%
Manufacturing Company
8%
Government
6%
Computer Software Company
29%
Healthcare Company
7%
Government
6%
Manufacturing Company
6%
Computer Software Company
15%
Financial Services Firm
9%
Government
8%
Manufacturing Company
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of variou...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS recor...
What do you like most about Secure Email Threat Defense?
Secure Email Threat Defense's scalability is good.
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Cisco's closest competition is Proofpoint. Both are in the same range in terms of pricing. Pricing is on the higher s...
What needs improvement with Secure Email Threat Defense?
The integration capability with other threat intelligence platforms is not optimal, as I have experienced difficulty ...
What do you like most about Microsoft Exchange Online Protection?
The initial setup was easy. The configuration process is very straightforward.
What needs improvement with Microsoft Exchange Online Protection?
I would like to improve the setting of rules in Microsoft Exchange Online Protection (EOP) as it is currently working...
What is your primary use case for Microsoft Exchange Online Protection?
I am using Microsoft Exchange Online Protection (EOP) ( /products/microsoft-exchange-online-protection-eop-reviews ) ...
 

Also Known As

MS Defender for Office 365
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
Microsoft EOP, MS Exchange Online Protection
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Information Not Available
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Exchange Online Protection (EOP) and other solutions. Updated: June 2025.
860,592 professionals have used our research since 2012.