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Cisco Secure Email Threat Defense vs Microsoft Exchange Online Protection (EOP) comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Sponsored
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
52
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (1st), Microsoft Security Suite (11th), Secure Email Gateway (SEG) (1st)
Cisco Secure Email Threat D...
Ranking in Email Security
20th
Average Rating
8.0
Reviews Sentiment
7.0
Number of Reviews
13
Ranking in other categories
No ranking in other categories
Microsoft Exchange Online P...
Ranking in Email Security
5th
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
38
Ranking in other categories
Anti-Malware Tools (7th)
 

Mindshare comparison

As of May 2025, in the Email Security category, the mindshare of Microsoft Defender for Office 365 is 12.9%, down from 18.3% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, down from 1.2% compared to the previous year. The mindshare of Microsoft Exchange Online Protection (EOP) is 6.7%, down from 9.1% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
Mike Bulyk - PeerSpot reviewer
Can quickly identify, track, tag, and categorize internal emails. Reporting accessibly via the main dashboard would be a great addition.
If Cisco could continue to develop integrations, whether it's internal tooling, Threat Grid, or AMP reporting which could be accessible via a single web page, that would be helpful. This would essentially add additional context on messages as well as files or links being detected. Potentially adding additional context on why certain messages are tagged as spam or malware. In our case, malware hasn't been detected yet, but spam certainly has been. Knowing what engines or which components of the message make it identifiable as spam, that could be useful. Additional context and reporting accessibly via the main dashboard would be great. There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting.
Nur Mohammad - PeerSpot reviewer
An effective email security solution that provides DLP, Safe Attachment, and Safe Links
If you want extensive email security, you need to purchase a Plan 2 license. Plan 1 and Plan 2 are the two plans for Microsoft Exchange Online Protection. Some customers hesitate to purchase this product because it adds some costs to them, which is necessary for them. It would be helpful for customers if Plan 1 features were included with EOP. However, they still need to purchase Plan 2 for advanced security features. One of our clients recently requested to compare Zimbra's features with Microsoft Exchange Online Protection. Zimbra is open source, while Microsoft Exchange Online Protection is not. When I compare both the products, many free features are available in Zimbra because it is open-source software. It makes no sense to request Microsoft Exchange Online Protection add all the features people get on open-source software like Zimbra. Hence, I would say whatever features Microsoft Exchange Online Protection has are enough. Microsoft has a dedicated research team that should research and add new techniques like phishing and spamming solutions to the product.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The technical support is good and quick to resolve issues."
"The most valuable feature of Microsoft Defender for Office 365 is the ease of use."
"Our customers are satisfied with Defender for 365 because Microsoft products are easy to use and customize to meet the client's needs. Everything is in one place, so we can adjust policies as needed for phishing, DLP, ATP, or any other security features that our clients want to apply."
"The most valuable feature of Microsoft Defender for Office 365 is data backups that we can provide through ticket requests."
"The risk level notifications are most valuable. We get to know what kind of intrusion or attack is there, and we can fix a problem on time."
"The benefit that stands out to me is the ability for multiple individuals to collaborate simultaneously within the same document. Additionally, there is the option to save the document directly in the integrated OneDrive or SharePoint."
"The email protection is excellent, especially in terms of anti-phishing policies."
"At the moment we are satisfied with this product. It's a stable, scalable, and resilient solution for us."
"I highly recommend it as one of the best choices."
"It has an efficient email filtering feature."
"The ability to see east-west traffic is its most valuable feature. Traditionally, email defense focuses on north-south, inbound-outbound, egress-ingress traffic. With Cisco Secure Email Cloud Mailbox, it's able to quickly identify, track, tag, and categorize emails that are internal. That can typically give us visibility into if there's an internal compromised account (for example). Someone can then use that internal compromised account to email additional accounts with either malicious software or links, but internal within that Office tenant. Effectively, that email message never leaves the tenant. Any of the mail gateways really do not have any method or way of seeing this traffic since it's not leaving the environment."
"The product offers protection, email security, anti-spam, and antivirus."
"Secure Email Threat Defense's scalability is good."
"This solution is easy to use."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"The features and functionalities are much better than Microsoft's in-built Defender plan."
"Online Protection's most valuable feature is its admin interface."
"Microsoft Exchange Online Protection (EOP) is the best email solution with more features and robust security, making it ideal for corporate use."
"With Microsoft Exchange Online Protection, if malware is attached to a mailer, it's very easy to go into the incident alert and find out what's happening with that identity and the mail."
"I like the product's ZAP feature."
"The most valuable feature of Microsoft Exchange Online Protection is the accidental release of information protection capabilities. Additionally, the solution is easy to use."
"We can migrate seamlessly without any disruptions to our operations."
"The most valuable feature is the ease of administration. Other solutions require complex administration, but Microsoft Exchange Online Protection is easier."
"It's all running in the backend, so it doesn't affect the app functionality."
 

Cons

"Specifically, within Microsoft Defender for Office 365, I want it to improve the DLP capabilities."
"Several simulation options are available within 365, and the phishing simulation could be better."
"Microsoft wants its well-paying customers to finish testing some of its half-baked products, find bugs, and report bugs back to Microsoft's team, which is a little frustrating for those who have to manage it and roll it up to thousands of people across the organization."
"The pre-sales cost calculations could be more transparent."
"Configuration requires going to a lot of places rather than just accessing one tab."
"The UI needs to be more user-friendly."
"We are always looking for others tools to increase automation on tasks. There can be better integration with other solutions, such as PowerPoint and email."
"I am generally satisfied with how it currently is. If I could improve anything, I would reduce the cost."
"The pricing could always be better."
"This solution could be improved by integration with Sandbox."
"The solution is a bit expensive."
"There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting."
"We encounter issues while searching for missing emails."
"The physical appliance has been discontinued, although the platform still exists."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"Having orchestration features added to Microsoft Exchange Online Protection, particularly automation and remediation, would be quite useful."
"Some of the searchability when looking for specifics in Exchange logs is tedious."
"Microsoft 365 Defender and EOP policies are stable with the proper license. However, with the basic policy, it's hard to say it's stable due to configuration limitations."
"Some features, like encryption, are not available."
"The security compliance features need to be improved. Sometimes, a client's mailbox becomes full because of retained information and not because of mail. I would like to see improvement in block rules as well."
"The solution lacks to elaborate on its spam policies."
"Microsoft has some training portals, but more could be developed."
"The solution must improve the user experience."
 

Pricing and Cost Advice

"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"The product is very expensive."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
"I was working in the government and it was too expensive for us to use our Microsoft products."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"The feedback from vendors and customer is that it is expensive."
"It is expensive compared to other vendors."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The solution’s pricing is manageable."
"Microsoft Exchange Online Protection is a good solution at an affordable price. It is a good investment."
"The solution is priced high and could be less expensive compared to other solutions."
"The solution is expensive but is backed by Microsoft's reputation."
"The product is bundled with Microsoft 365."
"The price of Microsoft Exchange Online Protection is reasonable."
"It is a low-price solution."
"The solution should reduce the cost."
"The pricing for the solution depends on what you are trying to achieve with the use of the product, but I know that it is not a cheaply priced product. Yearly payments have to be made towards the licensing fees of the solution."
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
9%
Manufacturing Company
8%
Government
6%
Computer Software Company
34%
Financial Services Firm
6%
Government
5%
Healthcare Company
5%
Computer Software Company
15%
Financial Services Firm
9%
Government
9%
Manufacturing Company
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of variou...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS recor...
What do you like most about Secure Email Threat Defense?
Secure Email Threat Defense's scalability is good.
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Cisco's closest competition is Proofpoint. Both are in the same range in terms of pricing. Pricing is on the higher s...
What needs improvement with Secure Email Threat Defense?
The physical appliance has been discontinued, although the platform still exists. Improvements here and there could b...
What do you like most about Microsoft Exchange Online Protection?
The initial setup was easy. The configuration process is very straightforward.
What needs improvement with Microsoft Exchange Online Protection?
I would like to improve the setting of rules in Microsoft Exchange Online Protection (EOP) as it is currently working...
What is your primary use case for Microsoft Exchange Online Protection?
I am using Microsoft Exchange Online Protection (EOP) ( /products/microsoft-exchange-online-protection-eop-reviews ) ...
 

Also Known As

MS Defender for Office 365
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
Microsoft EOP, MS Exchange Online Protection
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Information Not Available
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Exchange Online Protection (EOP) and other solutions. Updated: April 2025.
851,604 professionals have used our research since 2012.