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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cloudflare One
Sponsored
Ranking in Email Security
20th
Average Rating
8.6
Reviews Sentiment
6.5
Number of Reviews
23
Ranking in other categories
Secure Web Gateways (SWG) (12th), Data Loss Prevention (DLP) (22nd), Cloud Access Security Brokers (CASB) (12th), Distributed Denial-of-Service (DDoS) Protection (8th), Software Defined WAN (SD-WAN) Solutions (13th), Access Management (12th), Bot Management (3rd), ZTNA as a Service (8th), ZTNA (4th), Secure Access Service Edge (SASE) (9th), Remote Browser Isolation (RBI) (2nd)
Cisco Secure Email Threat D...
Ranking in Email Security
23rd
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (3rd), Microsoft Security Suite (9th), Secure Email Gateway (SEG) (2nd)
 

Mindshare comparison

As of August 2026, in the Email Security category, the mindshare of Cloudflare One is 1.7%, up from 1.4% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 5.7%, down from 11.6% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3655.7%
Cloudflare One1.7%
Cisco Secure Email Threat Defense1.1%
Other91.5%
Email Security
 

Featured Reviews

CV
Network Architect at IP Dimension
Cloud security has improved remote access and has reduced costs for smaller client sites
I have used Cloudflare One's Identity-Aware Proxy, and it is quite straightforward from what I have seen so far. The app registration on the Azure side integrates fully into Cloudflare, and I am very satisfied with that part because it is easy to set up. The integration of Cloudflare One's Secure Web Gateway and Zero Trust Network Access works without any issues. That part is pretty automatic, and if you complete the rest of the setup, it comes together by itself with no issues from my side. What makes it nice is that we can actually start replacing on-site firewalls at this stage for the smaller clients because it does not matter if they go to a coffee shop or work from home; they are still secured by the same connection. The hops get shorter and you get better latency. We have done testing to see if it is better. One thing that we did notice with our proof of concept with our current client is that they have people connecting from the UK. When they used their previous VPN solution, uploading CAD drawings and other files to the server took a long time. They mentioned that it is much quicker on Cloudflare One's solution. I definitely believe that is part of the improved performance, and I am satisfied with that as well. What is nice about Cloudflare One is that it makes the setup easier and also easier to train technicians to maintain it. Compared to legacy systems, we do not need to get fancy firewalls in place that are costly. That is definitely also a cost-saver with Cloudflare One.
NM
Enginner at Millennium Information Technologies
Has faced challenges with configuration, taking actions, and learning curve but benefits from centralized management and good technical support
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, are limited as ETD only supports sending audit logs. Customers have requirements for other system logs as well, which should be developed from their side. Another customer request is to restrict the IPs that can log in, which cannot be done from Cisco Secure Email Threat Defense yet. Any user with login details can log in. We can restrict the IPs in Cloud Mail Gateways, but not from Cisco Secure Email Threat Defense. It would be beneficial to improve this feature. Cisco Secure Email Threat Defense can take actions, such as requesting O365 to quarantine mail. In that case, the customer requires notification to the recipient from Cisco Secure Email Threat Defense. This option would be valuable if available. The real-time threat intelligence of Cisco Secure Email Threat Defense is an AI-based classification. It took one to two months to optimize the classification, but we still experience some false positives. Reducing the learning period would be beneficial. The learning curve shows that in the beginning, there are numerous false positives. For one month, we had to reclassify the false positives manually until the system learned. Reducing the learning time would be much better. Additional features desired in the next release include IP restrictions and user logging IP restrictions, ensuring only the customer environment can log in to Cisco Secure Email Threat Defense. Logs forwarding needs improvement as currently it only has audit logs. In Cloud Mail Gateway, we can create an IPsec tunnel to forward logs. However, in Cisco Secure Email Threat Defense, there is no option, and we must do API integration to send logs. Only SIM can get logs; Syslog cannot retrieve them.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"I'm very satisfied with the environment and the dashboard."
"Enables me to work from two locations."
"Cloudflare is by far the most effective solution that I have come across."
"The simplicity of the solution is its valuable features as almost no effort was needed to learn the configurations. It is also one of the cheapest firewalls available in this category."
"For Cloudflare Access, I am using the free plan...The most valuable feature is their protection."
"Cloudflare DDoS is better than its competitors for its security, deployment, and scalability."
"Cloudflare DDoS mitigates DDoS attacks."
"The best feature is rate limiting. If I'm expecting 500 visits per hour, Cloudflare will limit the requests if I suddenly get 50,000."
"Currently, the ease of deployment is the low-hanging fruit for Cisco email security."
"The advanced threat analytics and URL filtering in threat detection are good features that are working well."
"The solution is stable."
"I highly recommend it as one of the best choices."
"Regarding stability, Cisco Secure Email Threat Defense is very stable."
"The product offers protection, email security, anti-spam, and antivirus."
"Overall, it's certainly a very good idea to integrate another layer on top of Microsoft Advanced Threat Protection."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"The deployment capability is a great feature."
"It also gives the vulnerability status according to the versions you have selected. Let's say you have Google Chrome. It mentions the versions it has, and it updates. Within two hours of an update, it is reflected in the dashboard. That's really nice to have."
"We use Microsoft Defender for its ability to integrate with existing business technologies, which is beneficial for protecting business areas."
"The most valuable feature of Microsoft Defender for Office 365 is data backups that we can provide through ticket requests."
"The most valuable aspect of Microsoft Defender for Office 365 is its ability to protect us from malware."
"Overall, I would rate Microsoft Defender for Office 365 at a ten."
"Microsoft Defender for Office 365 has decreased my time to detection and time to respond by one hundred percent."
"Technical support is very good. They are knowledgeable and respond quickly."
 

Cons

"Our subscription plan for the solution has a limitation of bot signatures."
"The software has automated alerts, but the automated alerts are not available in the mobile app."
"From a logging perspective, it is still a bit difficult to see exactly what users are being blocked with the current views."
"The tool should provide on-premise versions. Currently, all versions are cloud-based."
"For the topic of improvement, providing some training material is one of my suggestions."
"Our customers no longer use Cloudflare because its service is subpar."
"The initial onboarding was causing us some confusion."
"They don't have a person to provide support for customers using the solution under their free plan."
"The solution is a bit expensive. It could be cheaper."
"There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting."
"The learning curve shows that in the beginning, there are numerous false positives. For one month, we had to reclassify the false positives manually until the system learned."
"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"The pricing could always be better."
"The physical appliance has been discontinued, although the platform still exists."
"I wouldn't recommend Cisco to others because I think Fortinet is better."
"We encounter issues while searching for missing emails."
"Microsoft security solutions work as expected. They are constantly updating the solutions to make them better. At the same time, the changes can impact a customer's environment, and we need to adjust settings. Sometimes we aren't aware of the changes, and nothing is pushed from the backend automatically."
"They can improve their security in a way where a customer can know if all their attachments are safe or not to open through a report. The solution does its job perfectly, but it never reports to the customer whether those attachments have been stopped before or not."
"About eight months ago, we started to measure the quantity of phishing and spam that we have been receiving, and it has been increasing a lot. That means that protection for our email is not as good as we were expecting."
"I am generally satisfied with how it currently is. If I could improve anything, I would reduce the cost."
"To improve Microsoft Defender for Office 365, it would be nice to have more accessibility for users to see on their end what they are doing that could cause a threat."
"Microsoft Defender for Office 365 could improve by giving customers information on techniques to prevent threats."
"One area for improvement is integration. For example, when it comes to external SaaS platforms, we were not able to get a lot of information on integrations with such apps for security and authentication."
"Microsoft Defender for Office 365's Mac functionality requires improvement to deliver the same level of protection found on Windows devices."
 

Pricing and Cost Advice

"The pricing is somewhere in the middle. I would rate the pricing a seven out of ten."
"Cloudflare Zero Trust Platform's pricing is good."
"The prices are slightly expensive."
"The solution is not that expensive."
"My company has to make yearly payments towards the licensing costs attached to the solution. There are no hidden charges apart from the licensing costs of the solution."
"The price tag is no longer $200,000, but rather $300,000 to $400,000. It's twice."
"The solution's pricing lacks transparency."
"The pricing of the solution is cheap. The licensing cost is also very low. I rate the cost and pricing a three out of ten."
"The solution’s pricing is manageable."
"The feedback from vendors and customer is that it is expensive."
"It is expensive compared to other vendors."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"I know that the product is incredibly expensive."
"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
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Top Industries

By visitors reading reviews
Construction Company
19%
Comms Service Provider
11%
Outsourcing Company
9%
Financial Services Firm
8%
Marketing Services Firm
11%
Construction Company
8%
Comms Service Provider
7%
Manufacturing Company
7%
Computer Software Company
11%
Manufacturing Company
9%
Financial Services Firm
9%
Comms Service Provider
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business10
Midsize Enterprise1
Large Enterprise12
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
 

Questions from the Community

What needs improvement with Cloudflare Zero Trust Platform?
In my opinion, Cloudflare One can be improved mainly through compatibility, as the integration should be much simpler...
What is your primary use case for Cloudflare Zero Trust Platform?
Cloudflare One's primary use case for my organization is to protect servers and to provide remote access with the VPN...
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, ...
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new ...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat De...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking ...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
 

Also Known As

Cloudflare Area 1 Email Security, Cloudflare Bot Management, Cloudflare Gateway, Cloudflare Zero Trust Platform, Cloudflare DDoS, Cloudflare SASE & SSE Platform
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

23andMe
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: August 2026.
908,877 professionals have used our research since 2012.