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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
22nd
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
60
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
 

Mindshare comparison

As of February 2026, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 9.1%, down from 13.7% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Market Share Distribution
ProductMarket Share (%)
Microsoft Defender for Office 3659.1%
Cisco Secure Email Threat Defense1.1%
Other89.8%
Email Security
 

Featured Reviews

reviewer2541525 - PeerSpot reviewer
Principal Cyber Prevent and Defense Engineer at a comms service provider with 1,001-5,000 employees
Clawback feature performs well but analytics and integration capabilities need improvement
The integration capability with other threat intelligence platforms is not optimal, as I have experienced difficulty in sending logs to our SIEM. Cisco Secure Email Threat Defense's flexibility could be enhanced while it mostly integrates with cloud solutions, but not on-premise. The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious. Regarding room for improvement, the significant number of false positives should be addressed. The solution does not adapt to behavioral analytics and does not make changes when it sees a pattern.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Cisco Secure Email Threat Defense's best features include user management of graymail, enhancing security awareness by allowing users to manage cold calls, sales-based items, and ensuring email compliance."
"Secure Email Threat Defense's scalability is good."
"The ability to see east-west traffic is its most valuable feature. Traditionally, email defense focuses on north-south, inbound-outbound, egress-ingress traffic. With Cisco Secure Email Cloud Mailbox, it's able to quickly identify, track, tag, and categorize emails that are internal. That can typically give us visibility into if there's an internal compromised account (for example). Someone can then use that internal compromised account to email additional accounts with either malicious software or links, but internal within that Office tenant. Effectively, that email message never leaves the tenant. Any of the mail gateways really do not have any method or way of seeing this traffic since it's not leaving the environment."
"The features and functionalities are much better than Microsoft's in-built Defender plan."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"Regarding stability, Cisco Secure Email Threat Defense is very stable."
"It has an efficient email filtering feature."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"The insights provided with Microsoft Defender for Office 365 are helpful because it comes with the E5 license, and by default, we can use a lot of capabilities."
"It’s easy to handle integrations, and we don't need a lot of people in our IT team."
"The most valuable feature is protection against malicious links, fishing, and impersonation. You can train people to be aware of these threats, but they're not always careful. When they're using their phones between meetings, they click on a link, and it's game over."
"I would say that 90% of the spam and phishing attack emails get blocked right off the bat."
"My experience with customer support and technical support for Microsoft Defender for Office 365 has been excellent."
"The insights provided with Microsoft Defender for Office 365 are helpful because it comes with the E5 license, and by default, we can use a lot of capabilities."
"The features I appreciate most about Microsoft Defender for Office 365 are admin notifications for potential threats along with protecting our Microsoft apps such as Outlook from potential phishing attacks."
"The good part is that you don't have to configure it, which is very convenient."
 

Cons

"The solution is a bit expensive."
"The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"The pricing could always be better."
"The physical appliance has been discontinued, although the platform still exists."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"Too many false positives and lacks an accurate capability to detect malicious SharePoint sites."
"Microsoft Defender for Office 365 could improve by giving customers information on techniques to prevent threats. For example, information about best practices on how to protect their own devices against hackers and scammers, such as educational information or training. This would help others have a better understanding of cyber security. Additionally, there can be more security features added."
"The changes to customer service, specifically the new model for support agreements, are not favorable."
"There is room for improvement in terms of reporting."
"The inbuilt analysis of false positives can be faster. It's not slow, but it can be faster."
"Microsoft should provide more documentation for users so they can self-educate. I would like to see more documentation for advanced security features."
"The certification training for Defender for 365 needs to be deeper and incorporate Sentinel. I took all the security courses except one, and Sentinel isn't included."
"In the areas of improvement for Microsoft Defender for Office 365, the console is the biggest challenge for me."
 

Pricing and Cost Advice

"The solution’s pricing is manageable."
"The feedback from vendors and customer is that it is expensive."
"It is expensive compared to other vendors."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The product is very expensive."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"The pricing has become expensive."
"The license is expensive because the cost is based on the number of users."
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Top Industries

By visitors reading reviews
Computer Software Company
12%
Marketing Services Firm
11%
Manufacturing Company
8%
Healthcare Company
7%
Computer Software Company
13%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business23
Midsize Enterprise10
Large Enterprise31
 

Questions from the Community

What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, I am not very aware of the pricing details.
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, ar...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat Defense.
What needs improvement with Microsoft Defender for Office 365?
The inbuilt analysis of false positives can be faster. It's not slow, but it can be faster.
What is your primary use case for Microsoft Defender for Office 365?
My use case for Microsoft Defender for Office 365 is for email protection, safe links, protection of links, documents, protecting my documents, and protecting attachments. I also use it to conduct ...
 

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: February 2026.
881,821 professionals have used our research since 2012.