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Cisco Secure Email Threat Defense vs Proofpoint Email Protection comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Sponsored
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
7.0
Number of Reviews
52
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Cisco Secure Email Threat D...
Ranking in Email Security
25th
Average Rating
8.0
Reviews Sentiment
7.1
Number of Reviews
14
Ranking in other categories
No ranking in other categories
Proofpoint Email Protection
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
52
Ranking in other categories
Security Awareness Training (2nd), Digital Risk Protection (3rd), Office 365 Protection (2nd), Secure Email Gateway (SEG) (3rd)
 

Mindshare comparison

As of July 2025, in the Email Security category, the mindshare of Microsoft Defender for Office 365 is 12.3%, down from 16.9% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Proofpoint Email Protection is 8.4%, down from 10.3% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
Enrique-Diaz Jolly - PeerSpot reviewer
Provides comprehensive threat protection with suggestions for modernizing controls
I use the email gateway as the core of the email exchange between the Internet and our domain. The email gateway serves as the email exchanger The product offers protection, email security, anti-spam, and antivirus. It includes threat intelligence with advanced malware protection and many…
AhmedRamadan - PeerSpot reviewer
Optimize email security with effective sandboxing and auto Pull for quarantine
Proofpoint is used as an email security gateway for big enterprises, primarily for their on-premises servers. Many customers also use it alongside Office 365 Proofpoint offers a complete solution for email security with features like DLP, email archiving, and encryption. The most valuable…

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the individuals within our organization who are affected."
"Defender is a SaaS platform, so it offers more flexibility. Managing the permissions is easier. The solution's automated detection and response features are scalable."
"I like its investigation capabilities, as that is what is most important to me. It is fairly simple with a user-friendly interface."
"The product is not resource-intensive."
"Since we have started using the solution, there have been fewer compromises."
"Does a thorough job of examining email and URLs for malicious content."
"Microsoft Defender for Office 365 helps people to work remotely. It is a secure solution. We don't need to use our company's computers or get VPN connections to the networks. I can control how they share screens and what they send to the devices. It keeps our organizations confidential and sensitive information safe."
"Defender enables us to secure all 365-related activity from a single place. It gives us visibility into everything happening in Outlook, protecting us against phishing and other email-based threats. Defender helps us detect any suspicious behaviors."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"The product offers protection, email security, anti-spam, and antivirus."
"It has an efficient email filtering feature."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"On ease of use, it rates very high. It's something that I was able to get into without really looking at any documentation. I wanted to see what it felt like before I started looking at any documentation on how to use it, and it was very easy to use. It works very smoothly. The user experience is very intuitive. They did an amazing job on that."
"The solution is stable."
"Regarding stability, Cisco Secure Email Threat Defense is very stable."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"It was easy to set up."
"Proofpoint Email Protection's initial installation is straightforward. It took us less than a day to complete the implementation."
"Proofpoint Email Protection is the best solution from the perspective of email security."
"The solution offers very good flexibility. You can blacklist or whitelist with ease."
"It's a mature product. It does a good job in detection."
"The anti-spam features are excellent on the email firewalls."
"The most valuable feature is the option to edit the inbound security."
"It's easy to use, even for those new to IT."
 

Cons

"We are always looking for others tools to increase automation on tasks. There can be better integration with other solutions, such as PowerPoint and email."
"About eight months ago, we started to measure the quantity of phishing and spam that we have been receiving, and it has been increasing a lot. That means that protection for our email is not as good as we were expecting."
"The XDR dashboard has room for improvement."
"We need a separate license and we don't know how to get the license that is required."
"Sometimes, phishing emails manage to pass through the filter, so the system needs to enhance its phishing email detection capabilities."
"Configuring the default strategies and policies in Microsoft Defender for Cloud Apps generates a lot of noise and false positives."
"Configuration requires going to a lot of places rather than just accessing one tab."
"Specifically, within Microsoft Defender for Office 365, I want it to improve the DLP capabilities."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious."
"The pricing could always be better."
"We encounter issues while searching for missing emails."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"This solution could be improved by integration with Sandbox."
"The physical appliance has been discontinued, although the platform still exists."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"Proofpoint Email Protection is an expensive solution."
"The high cost of the product is an area of concern where improvements are required."
"It's scalable, but the devil's in the details — you have to know your email volumes."
"The flexibility of the solution can be improved."
"Proofpoint Email Protection could improve on the training. Every organization is different and to fine-tune it to block everything properly there needs to be better training. Sometimes it can block some of the information it shouldn't."
"The initial setup is complex."
"The false positives are an issue."
"The scalability can be improved, and the solution can be optimized."
 

Pricing and Cost Advice

"The product is very expensive."
"The license is expensive because the cost is based on the number of users."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"It's a user-base subscription."
"The product is expensive."
"The pricing has become expensive."
"The solution could be better by simplifying the business model of their licensing. It was hard to figure out how to get the licensing done for the environment, initially."
"I was working in the government and it was too expensive for us to use our Microsoft products."
"It is expensive compared to other vendors."
"The solution’s pricing is manageable."
"The feedback from vendors and customer is that it is expensive."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The solution charges per user per month to use it. There are not any additional fees in addition to the standard living fees."
"Proofpoint is fairly expensive."
"The price is reasonable."
"The end customer is buying our solution, which can be for monthly or annual usage depending on our payment and business model."
"In general, the pricing is competitive."
"The licensing is basically $8/user."
"The licensing cost of Proofpoint Email Protection is a lot higher than other solutions, such as Barracuda."
"Pricing has recently been increased and the cost is a downside"
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
9%
Manufacturing Company
8%
Government
6%
Computer Software Company
29%
Healthcare Company
7%
Government
6%
Manufacturing Company
6%
Computer Software Company
15%
Educational Organization
11%
Financial Services Firm
10%
Manufacturing Company
8%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of variou...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS recor...
What do you like most about Secure Email Threat Defense?
Secure Email Threat Defense's scalability is good.
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Cisco's closest competition is Proofpoint. Both are in the same range in terms of pricing. Pricing is on the higher s...
What needs improvement with Secure Email Threat Defense?
The integration capability with other threat intelligence platforms is not optimal, as I have experienced difficulty ...
What is your experience regarding pricing and costs for Proofpoint Email Protection?
In terms of pricing, it is okay compared to others. I would say it is normal. Additional costs do come in, but it enh...
What needs improvement with Proofpoint Email Protection?
It became very expensive due to the nature of local circumstances, and I may advise Proofpoint to adjust marketing so...
 

Also Known As

MS Defender for Office 365
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
Proofpoint Enterprise Protection, Cofense PhishMe, Proofpoint Digital Protection
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Blocket, University of Waterloo, Lincoln Memorial University, WellSpan Health, U-Haul, Carestream Health, Westinghouse
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Proofpoint Email Protection and other solutions. Updated: June 2025.
860,592 professionals have used our research since 2012.