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Cisco Secure Email Threat Defense vs Proofpoint Email Protection comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
23rd
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Proofpoint Email Protection
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
6.7
Number of Reviews
111
Ranking in other categories
Advanced Threat Protection (ATP) (2nd), Digital Risk Protection (3rd), Office 365 Protection (1st), Secure Email Gateway (SEG) (1st)
 

Mindshare comparison

As of September 2026, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Proofpoint Email Protection is 5.9%, down from 7.5% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Proofpoint Email Protection5.9%
Cisco Secure Email Threat Defense1.1%
Other93.0%
Email Security
 

Featured Reviews

GC
Senior Cybersecurity Engineer at a financial services firm with 11-50 employees
Provides robust email security features but requires improved modernization and complexity management
Modernization is an area that could be improved for Cisco Secure Email Threat Defense, as some features have lagged behind newer competitors, potentially offering more advanced analysis capabilities. The initial setup is not straightforward and requires expertise and time to master configurations such as spoofing and DLP. More control over backend functionalities and simplifying rule management could enhance user experience. The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration. Furthermore, the pricing might deter new users who could opt for alternative, more cost-effective solutions.
Siva_Prasad - PeerSpot reviewer
Senior Consultant at a tech vendor with 10,001+ employees
Email defenses have reduced phishing incidents and protect sensitive data across our enterprise
As things are evolving and threats develop in unpredictable ways, Proofpoint must adopt AI solutions and agentic solutions more aggressively and provide them to customers as part of service offerings. Inbuilt AI solutions would add more value and make Proofpoint a more premium choice for customers. With the help of AI solutions, agentic AI, and generative AI capabilities, the product would be more efficient than it currently is. Filtering false positives is highly challenging because it is impossible for humans to identify which emails are genuine and which are spam. Proofpoint should focus more on this area with back-end agents or other tools. Proofpoint should decide which emails are genuine and which are spam so it is not a challenge for end users. When receiving an email, end users should not have to determine whether to respond or not. Proofpoint should not release such spam emails and should strictly block such spam and spoof emails based on connection IPs. Currently, false positives occur in the product, and while this occurs in every product, it is an area where Proofpoint can focus on improving and reducing false positives. One email is enough for an end user to be deceived and lose money, so addressing this area is critical.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"On ease of use, it rates very high."
"Regarding stability, Cisco Secure Email Threat Defense is very stable."
"It's very easy to deploy and configure."
"This solution is easy to use."
"The product offers protection, email security, anti-spam, and antivirus."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"I highly recommend it as one of the best choices."
"It has been comprehensive and easy to use for both users and administrators."
"Considering Proofpoint Email Protection's end-to-end visibility in email threats, focusing on both the email and the person, it accomplishes what automation does in half the human work."
"Proofpoint Email Protection ensures users have clean mailboxes and are not bothered by unwanted email."
"Proofpoint Email Protection has positively impacted our organization's protection and has maintained security very well."
"It was easy to set up."
"Proofpoint Email Protection is a great security tool that is not only proactive but also reactive on a case-to-case basis and provides all the mature tools that can be utilized for the first layer and second layer message defense."
"Its anti-phishing functionality is the most valuable. Certainly, the biggest problem I have is phishing."
"A one-stop shop for email protection"
 

Cons

"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"The solution is a bit expensive. It could be cheaper."
"The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious."
"The physical appliance has been discontinued, although the platform still exists."
"There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting."
"The search area has room for improvement."
"I wouldn't recommend Cisco to others because I think Fortinet is better."
"Proofpoint is a little bit expensive."
"One major threat is QR code phishing, along with TOAD (Telephone-Oriented Attack Delivery). TOAD attacks don't include links, URLs, or attachments in emails. Instead, attackers try to trick you into calling them, often by offering something enticing like a 50% discount on football matches."
"The support team was a bit slow."
"Proofpoint Email Protection could improve by allowing more customization of the reports, such as exceptions and black-and-white lists."
"Proofpoint Email Protection has a lot of false positives, and the infrastructure is a bit complex."
"As far as visibility goes, it is definitely attainable, but additional appliances must be purchased for Proofpoint. I would rate visibility at approximately 50 to 60 percent."
"The scalability can be improved, and the solution can be optimized."
"Sometimes it detects false positives."
 

Pricing and Cost Advice

"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The feedback from vendors and customer is that it is expensive."
"It is expensive compared to other vendors."
"The solution’s pricing is manageable."
"The solution is expensive."
"In general, the pricing is competitive."
"The end customer is buying our solution, which can be for monthly or annual usage depending on our payment and business model."
"Proofpoint Email Protection is a reasonably priced product, which means that it is neither too low nor too high in terms of price."
"The licensing cost of Proofpoint Email Protection is a lot higher than other solutions, such as Barracuda."
"I rate the product price a seven on a scale of one to ten, where one is low price and ten is high price."
"Proofpoint Email Protection has comparable pricing."
"The licensing model for Proofpoint Email Protection is simple. It's based on the number of users. Price-wise, Proofpoint Email Protection is a five out of ten because it's a pretty expensive solution."
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Top Industries

By visitors reading reviews
Marketing Services Firm
11%
Outsourcing Company
9%
Comms Service Provider
8%
Healthcare Company
8%
Financial Services Firm
13%
Outsourcing Company
10%
Manufacturing Company
10%
Comms Service Provider
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business30
Midsize Enterprise25
Large Enterprise62
 

Questions from the Community

What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, I am not very aware of the pricing details.
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, ar...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat Defense.
What needs improvement with Proofpoint Email Protection?
To improve Proofpoint Email Protection, I suggest breaking down the URL into one versus three different GUIs. Regarding Proofpoint Email Protection's AI capabilities, I think its governance and sec...
What is your primary use case for Proofpoint Email Protection?
My main use case for Proofpoint Email Protection includes phishing emails, spam, URL isolation, and training. I utilize the email protect portal to ensure that none of our employees in any of the b...
 

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
Proofpoint Enterprise Protection, Proofpoint Digital Protection
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
Blocket, University of Waterloo, Lincoln Memorial University, WellSpan Health, U-Haul, Carestream Health, Westinghouse
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Proofpoint Email Protection and other solutions. Updated: September 2026.
914,109 professionals have used our research since 2012.